Type-1 angiotensin II receptor
Details
- Name
- Type-1 angiotensin II receptor
- Synonyms
- AGTR1A
- AGTR1B
- Angiotensin II type-1 receptor
- AT1
- AT1AR
- AT1BR
- AT2R1
- AT2R1B
- Gene Name
- AGTR1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0009910|Type-1 angiotensin II receptor MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK IIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPL FYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
- Number of residues
- 359
- Molecular Weight
- 41060.53
- Theoretical pI
- 9.71
- GO Classification
- Functionsangiotensin type I receptor activity / angiotensin type II receptor activity / bradykinin receptor binding / protein heterodimerization activityProcessesangiotensin-activated signaling pathway / calcium-mediated signaling / cell chemotaxis / G-protein coupled receptor signaling pathway / kidney development / low-density lipoprotein particle remodeling / phospholipase C-activating angiotensin-activated signaling pathway / phospholipase C-activating G-protein coupled receptor signaling pathway / positive regulation of cellular protein metabolic process / positive regulation of cholesterol esterification / positive regulation of cytosolic calcium ion concentration / positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway / positive regulation of inflammatory response / positive regulation of macrophage derived foam cell differentiation / positive regulation of NAD(P)H oxidase activity / positive regulation of phospholipase A2 activity / positive regulation of reactive oxygen species metabolic process / regulation of blood vessel size by renin-angiotensin / regulation of cell growth / regulation of cell proliferation / regulation of inflammatory response / regulation of renal sodium excretion / regulation of systemic arterial blood pressure by renin-angiotensin / regulation of vasoconstriction / regulation of vasodilation / renin-angiotensin regulation of aldosterone production / Rho protein signal transductionComponentscytosol / integral component of membrane / integral component of plasma membrane / intracellular / plasma membrane
- General Function
- Protein heterodimerization activity
- Specific Function
- Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
- Pfam Domain Function
- 7tm_1 (PF00001)
- Transmembrane Regions
- 28-52 65-87 103-124 143-162 193-214 241-262 276-296
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0009911|Type-1 angiotensin II receptor (AGTR1) ATGATTCTCAACTCTTCTACTGAAGATGGTATTAAAAGAATCCAAGATGATTGTCCCAAA GCTGGAAGGCATAATTACATATTTGTCATGATTCCTACTTTATACAGTATCATCTTTGTG GTGGGAATATTTGGAAACAGCTTGGTGGTGATAGTCATTTACTTTTATATGAAGCTGAAG ACTGTGGCCAGTGTTTTTCTTTTGAATTTAGCACTGGCTGACTTATGCTTTTTACTGACT TTGCCACTATGGGCTGTCTACACAGCTATGGAATACCGCTGGCCCTTTGGCAATTACCTA TGTAAGATTGCTTCAGCCAGCGTCAGTTTCAACCTGTACGCTAGTGTGTTTCTACTCACG TGTCTCAGCATTGATCGATACCTGGCTATTGTTCACCCAATGAAGTCCCGCCTTCGACGC ACAATGCTTGTAGCCAAAGTCACCTGCATCATCATTTGGCTGCTGGCAGGCTTGGCCAGT TTGCCAGCTATAATCCATCGAAATGTATTTTTCATTGAGAACACCAATATTACAGTTTGT GCTTTCCATTATGAGTCCCAAAATTCAACCCTCCCGATAGGGCTGGGCCTGACCAAAAAT ATACTGGGTTTCCTGTTTCCTTTTCTGATCATTCTTACAAGTTATACTCTTATTTGGAAG GCCCTAAAGAAGGCTTATGAAATTCAGAAGAACAAACCAAGAAATGATGATATTTTTAAG ATAATTATGGCAATTGTGCTTTTCTTTTTCTTTTCCTGGATTCCCCACCAAATATTCACT TTTCTGGATGTATTGATTCAACTAGGCATCATACGTGACTGTAGAATTGCAGATATTGTG GACACGGCCATGCCTATCACCATTTGTATAGCTTATTTTAACAATTGCCTGAATCCTCTT TTTTATGGCTTTCTGGGGAAAAAATTTAAAAGATATTTTCTCCAGCTTCTAAAATATATT CCCCCAAAAGCCAAATCCCACTCAAACCTTTCAACAAAAATGAGCACGCTTTCCTACCGC CCCTCAGATAATGTAAGCTCATCCACCAAGAAGCCTGCACCATGTTTTGAGGTTGAGTGA
- Chromosome Location
- 3
- Locus
- 3q21-q25
- External Identifiers
Resource Link UniProtKB ID P30556 UniProtKB Entry Name AGTR1_HUMAN GenBank Protein ID 179122 GenBank Gene ID M91464 GenAtlas ID AGTR1 HGNC ID HGNC:336 - General References
- Mauzy CA, Hwang O, Egloff AM, Wu LH, Chung FZ: Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor. Biochem Biophys Res Commun. 1992 Jul 15;186(1):277-84. [Article]
- Furuta H, Guo DF, Inagami T: Molecular cloning and sequencing of the gene encoding human angiotensin II type 1 receptor. Biochem Biophys Res Commun. 1992 Feb 28;183(1):8-13. [Article]
- Bergsma DJ, Ellis C, Kumar C, Nuthulaganti P, Kersten H, Elshourbagy N, Griffin E, Stadel JM, Aiyar N: Cloning and characterization of a human angiotensin II type 1 receptor. Biochem Biophys Res Commun. 1992 Mar 31;183(3):989-95. [Article]
- Takayanagi R, Ohnaka K, Sakai Y, Nakao R, Yanase T, Haji M, Inagami T, Furuta H, Gou DF, Nakamuta M, et al.: Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptor. Biochem Biophys Res Commun. 1992 Mar 16;183(2):910-6. [Article]
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- Konishi H, Kuroda S, Inada Y, Fujisawa Y: Novel subtype of human angiotensin II type 1 receptor: cDNA cloning and expression. Biochem Biophys Res Commun. 1994 Mar 15;199(2):467-74. [Article]
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- Kostenis E, Milligan G, Christopoulos A, Sanchez-Ferrer CF, Heringer-Walther S, Sexton PM, Gembardt F, Kellett E, Martini L, Vanderheyden P, Schultheiss HP, Walther T: G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor. Circulation. 2005 Apr 12;111(14):1806-13. Epub 2005 Apr 4. [Article]
- Jia W, Lu Z, Fu Y, Wang HP, Wang LH, Chi H, Yuan ZF, Zheng ZB, Song LN, Han HH, Liang YM, Wang JL, Cai Y, Zhang YK, Deng YL, Ying WT, He SM, Qian XH: A strategy for precise and large scale identification of core fucosylated glycoproteins. Mol Cell Proteomics. 2009 May;8(5):913-23. doi: 10.1074/mcp.M800504-MCP200. Epub 2009 Jan 12. [Article]
- Gribouval O, Gonzales M, Neuhaus T, Aziza J, Bieth E, Laurent N, Bouton JM, Feuillet F, Makni S, Ben Amar H, Laube G, Delezoide AL, Bouvier R, Dijoud F, Ollagnon-Roman E, Roume J, Joubert M, Antignac C, Gubler MC: Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis. Nat Genet. 2005 Sep;37(9):964-8. Epub 2005 Aug 14. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00177 Valsartan approved, investigational yes antagonist Details DB00275 Olmesartan approved, investigational yes antagonist Details DB00678 Losartan approved yes antagonist Details DB00796 Candesartan cilexetil approved yes antagonist Details DB00876 Eprosartan approved yes antagonist Details DB00966 Telmisartan approved, investigational yes antagonist Details DB01029 Irbesartan approved, investigational yes antagonist Details DB01342 Forasartan experimental yes antagonist Details DB01347 Saprisartan experimental yes antagonist Details DB01349 Tasosartan experimental yes antagonist Details DB05739 CYT006-AngQb investigational unknown Details DB08822 Azilsartan medoxomil approved, investigational yes antagonist Details DB09279 Fimasartan investigational yes antagonist Details DB13919 Candesartan experimental yes antagonist Details DB11842 Angiotensin II approved, investigational unknown agonist Details