Mannosyl-oligosaccharide alpha-1,2-mannosidase
Details
- Name
- Mannosyl-oligosaccharide alpha-1,2-mannosidase
- Synonyms
- 3.2.1.113
- Man(9)-alpha-mannosidase
- Gene Name
- MSDC
- Organism
- Penicillium citrinum
- Amino acid sequence
>lcl|BSEQ0020569|Mannosyl-oligosaccharide alpha-1,2-mannosidase MRLPVSFPLTVLSLLGSTIAHPYGETEAVLRSEPKSNQAKADAVKEAFQHAWNGYMKYAF PHDELTPVSNGHADSRNGWGASAVDALSTAVIMGKADVVNAILEHVADIDFSKTSDTVSL FETTIRYLAGMLSGYDLLQGPAKNLVDNQDLIDGLLDQSRNLADVLKFAFDTPSGVPYNN INITSHGNDGATTNGLAVTGTLVLEWTRLSDLTGDEEYAKLSQKAESYLLKPQPSSSEPF PGLVGSSININDGQFADSRVSWNGGDDSFYEYLIKMYVYDPKRFETYKDRWVLAAESTIK HLKSHPKSRPDLTFLSSYSNRNYDLSSQHLTCFDGGSFLLGGTVLDRQDFIDFGLELVDG CEATYNSTLTKIGPDSWGWDPKKVPSDQKEFYEKAGFYISSGSYVLRPEVIESFYYAHRV TGKEIYRDWVWNAFVAINSTCRTDSGFAAVSDVNKANGGSKYDNQESFLFAEVMKYSYLA HSEDAAWQVQKGGKNTFVYNTEAHPISVARN
- Number of residues
- 511
- Molecular Weight
- 56569.37
- Theoretical pI
- 4.83
- GO Classification
- Functionscalcium ion binding / mannosyl-oligosaccharide 1,2-alpha-mannosidase activityProcessesprotein glycosylationComponentsextracellular region / membrane
- General Function
- Mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
- Specific Function
- Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).
- Pfam Domain Function
- Glyco_hydro_47 (PF01532)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0003546|1536 bp ATGCGTCTTCCAGTGTCATTCCCTCTGACAGTTCTGAGCTTGTTGGGCTCGACAATTGCT CATCCCTATGGCGAGACCGAGGCTGTTTTGCGAAGTGAGCCTAAGAGTAACCAAGCCAAA GCCGACGCTGTCAAAGAGGCCTTCCAGCACGCGTGGAATGGATACATGAAATATGCCTTC CCTCATGACGAGTTGACTCCTGTCAGCAATGGTCATGCCGACTCTAGAAATGGATGGGGG GCCTCAGCAGTTGACGCGCTTTCCACGGCCGTGATTATGGGCAAAGCGGATGTTGTGAAT GCCATTCTCGAGCATGTCGCCGACATTGACTTCTCGAAGACCTCGGATACCGTCAGTCTT TTCGAAACAACCATTCGTTACTTGGCGGGTATGCTATCGGGTTACGATCTGCTTCAGGGA CCTGCCAAGAATTTGGTCGATAACCAAGACCTCATTGACGGATTACTGGACCAGTCAAGA AACCTGGCCGATGTTCTGAAATTTGCTTTCGATACCCCTTCGGGTGTCCCCTATAATAAC ATCAACATCACCTCGCACGGAAATGACGGCGCAACCACTAATGGCCTCGCTGTGACTGGC ACACTGGTTCTGGAATGGACTCGTCTTTCTGATCTGACAGGTGATGAAGAGTATGCCAAA TTAAGCCAGAAGGCCGAGTCTTATCTGCTCAAGCCGCAGCCATCGAGCAGCGAGCCTTTC CCTGGTCTCGTAGGCAGCTCGATTAATATCAACGATGGTCAATTTGCCGACTCCAGAGTC TCTTGGAATGGAGGTGACGATTCATTCTATGAGTACCTGATCAAGATGTACGTGTACGAC CCTAAGCGGTTTGAGACATACAAGGATCGCTGGGTCCTGGCAGCCGAGTCGACTATCAAG CATCTCAAGTCGCACCCGAAGTCCCGCCCGGACTTGACGTTCCTGTCTTCCTACAGTAAC AGGAATTATGATCTCAGCTCGCAGCACCTGACTTGCTTCGATGGCGGTAGTTTTCTTCTG GGCGGTACCGTTCTGGACCGCCAGGACTTCATTGATTTTGGTCTGGAGCTTGTTGACGGC TGTGAGGCTACCTACAATTCTACTCTGACCAAGATCGGTCCAGACTCGTGGGGCTGGGAC CCAAAGAAGGTCCCCAGTGACCAGAAAGAATTCTATGAAAAAGCTGGCTTCTATATCAGT AGTGGTTCGTACGTCCTCCGCCCCGAGGTGATTGAAAGTTTTTACTACGCGCACCGCGTT ACTGGAAAGGAAATTTACCGTGACTGGGTTTGGAATGCGTTCGTTGCAATTAACTCGACC TGCCGTACCGACTCTGGTTTCGCTGCTGTATCCGACGTCAACAAGGCGAACGGTGGCTCC AAGTACGACAACCAAGAGAGTTTCCTCTTCGCCGAGGTCATGAAGTACTCATATCTCGCT CATTCCGAGGATGCTGCATGGCAAGTCCAGAAGGGTGGCAAGAATACCTTCGTGTACAAC ACTGAGGCTCACCCGATTAGCGTCGCACGCAACTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P31723 UniProtKB Entry Name MAN12_PENCI GenBank Protein ID 987684 GenBank Gene ID D45839 - General References
- Yoshida T, Ichishima E: Molecular cloning and nucleotide sequence of the genomic DNA for 1,2-alpha-D-mannosidase gene, msdC from Penicillium citrinum. Biochim Biophys Acta. 1995 Aug 22;1263(2):159-62. [Article]
- Yoshida T, Inoue T, Ichishima E: 1,2-alpha-D-mannosidase from Penicillium citrinum: molecular and enzymic properties of two isoenzymes. Biochem J. 1993 Mar 1;290 ( Pt 2):349-54. [Article]
- Lobsanov YD, Vallee F, Imberty A, Yoshida T, Yip P, Herscovics A, Howell PL: Structure of Penicillium citrinum alpha 1,2-mannosidase reveals the basis for differences in specificity of the endoplasmic reticulum and Golgi class I enzymes. J Biol Chem. 2002 Feb 15;277(7):5620-30. Epub 2001 Nov 19. [Article]