T-lymphocyte activation antigen CD80
Details
- Name
- T-lymphocyte activation antigen CD80
- Synonyms
- Activation B7-1 antigen
- B7
- BB1
- CD28LG
- CD28LG1
- CTLA-4 counter-receptor B7.1
- LAB7
- Gene Name
- CD80
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0001690|T-lymphocyte activation antigen CD80 MGHTRRQGTSPSKCPYLNFFQLLVLAGLSHFCSGVIHVTKEVKEVATLSCGHNVSVEELA QTRIYWQKEKKMVLTMMSGDMNIWPEYKNRTIFDITNNLSIVILALRPSDEGTYECVVLK YEKDAFKREHLAEVTLSVKADFPTPSISDFEIPTSNIRRIICSTSGGFPEPHLSWLENGE ELNAINTTVSQDPETELYAVSSKLDFNMTTNHSFMCLIKYGHLRVNQTFNWNTTKQEHFP DNLLPSWAITLISVNGIFVICCLTYCFAPRCRERRRNERLRRESVRPV
- Number of residues
- 288
- Molecular Weight
- 33047.625
- Theoretical pI
- 7.71
- GO Classification
- Functionscoreceptor activity / virus receptor activityProcessescell-cell signaling / cellular response to lipopolysaccharide / epidermal growth factor receptor signaling pathway / Fc-epsilon receptor signaling pathway / fibroblast growth factor receptor signaling pathway / innate immune response / intracellular signal transduction / neurotrophin TRK receptor signaling pathway / phosphatidylinositol-mediated signaling / positive regulation of alpha-beta T cell proliferation / positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process / positive regulation of interleukin-2 biosynthetic process / positive regulation of peptidyl-tyrosine phosphorylation / positive regulation of signal transduction / positive regulation of T-helper 1 cell differentiation / positive regulation of transcription, DNA-templated / T cell activation / T cell costimulationComponentscell surface / external side of plasma membrane / integral component of membrane / intracellular / plasma membrane
- General Function
- Virus receptor activity
- Specific Function
- Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.(Microbial infection) Acts as a receptor for adenovirus subgroup B.
- Pfam Domain Function
- Transmembrane Regions
- 243-263
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0016223|T-lymphocyte activation antigen CD80 (CD80) ATGGGCCACACACGGAGGCAGGGAACATCACCATCCAAGTGTCCATACCTCAATTTCTTT CAGCTCTTGGTGCTGGCTGGTCTTTCTCACTTCTGTTCAGGTGTTATCCACGTGACCAAG GAAGTGAAAGAAGTGGCAACGCTGTCCTGTGGTCACAATGTTTCTGTTGAAGAGCTGGCA CAAACTCGCATCTACTGGCAAAAGGAGAAGAAAATGGTGCTGACTATGATGTCTGGGGAC ATGAATATATGGCCCGAGTACAAGAACCGGACCATCTTTGATATCACTAATAACCTCTCC ATTGTGATCCTGGCTCTGCGCCCATCTGACGAGGGCACATACGAGTGTGTTGTTCTGAAG TATGAAAAAGACGCTTTCAAGCGGGAACACCTGGCTGAAGTGACGTTATCAGTCAAAGCT GACTTCCCTACACCTAGTATATCTGACTTTGAAATTCCAACTTCTAATATTAGAAGGATA ATTTGCTCAACCTCTGGAGGTTTTCCAGAGCCTCACCTCTCCTGGTTGGAAAATGGAGAA GAATTAAATGCCATCAACACAACAGTTTCCCAAGATCCTGAAACTGAGCTCTATGCTGTT AGCAGCAAACTGGATTTCAATATGACAACCAACCACAGCTTCATGTGTCTCATCAAGTAT GGACATTTAAGAGTGAATCAGACCTTCAACTGGAATACAACCAAGCAAGAGCATTTTCCT GATAACCTGCTCCCATCCTGGGCCATTACCTTAATCTCAGTAAATGGAATTTTTGTGATA TGCTGCCTGACCTACTGCTTTGCCCCAAGATGCAGAGAGAGAAGGAGGAATGAGAGATTG AGAAGGGAAAGTGTACGCCCTGTATAA
- Chromosome Location
- 3
- Locus
- 3q13.3-q21
- External Identifiers
Resource Link UniProtKB ID P33681 UniProtKB Entry Name CD80_HUMAN GenBank Protein ID 306916 GenBank Gene ID M27533 GenAtlas ID CD80 HGNC ID HGNC:1700 - General References
- Freeman GJ, Freedman AS, Segil JM, Lee G, Whitman JF, Nadler LM: B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells. J Immunol. 1989 Oct 15;143(8):2714-22. [Article]
- Selvakumar A, Mohanraj BK, Eddy RL, Shows TB, White PC, Dupont B: Genomic organization and chromosomal location of the human gene encoding the B-lymphocyte activation antigen B7. Immunogenetics. 1992;36(3):175-81. [Article]
- Kakoulidou M, Giscombe R, Zhao X, Lefvert AK, Wang X: Human Soluble CD80 is generated by alternative splicing, and recombinant soluble CD80 binds to CD28 and CD152 influencing T-cell activation. Scand J Immunol. 2007 Nov;66(5):529-37. [Article]
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- Freeman GJ, Gray GS, Gimmi CD, Lombard DB, Zhou LJ, White M, Fingeroth JD, Gribben JG, Nadler LM: Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7. J Exp Med. 1991 Sep 1;174(3):625-31. [Article]
- Lanier LL, O'Fallon S, Somoza C, Phillips JH, Linsley PS, Okumura K, Ito D, Azuma M: CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL. J Immunol. 1995 Jan 1;154(1):97-105. [Article]
- Vandenborre K, Van Gool SW, Kasran A, Ceuppens JL, Boogaerts MA, Vandenberghe P: Interaction of CTLA-4 (CD152) with CD80 or CD86 inhibits human T-cell activation. Immunology. 1999 Nov;98(3):413-21. [Article]
- Short JJ, Vasu C, Holterman MJ, Curiel DT, Pereboev A: Members of adenovirus species B utilize CD80 and CD86 as cellular attachment receptors. Virus Res. 2006 Dec;122(1-2):144-53. Epub 2006 Aug 22. [Article]
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