5-hydroxytryptamine receptor 7
Details
- Name
- 5-hydroxytryptamine receptor 7
- Synonyms
- 5-HT-7
- 5-HT-X
- Serotonin receptor 7
- Gene Name
- HTR7
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0001296|5-hydroxytryptamine receptor 7 MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK LAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
- Number of residues
- 479
- Molecular Weight
- 53554.43
- Theoretical pI
- 8.97
- GO Classification
- Functionsserotonin receptor activityProcessesblood circulation / circadian rhythm / G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger / serotonin receptor signaling pathway / smooth muscle contraction / synaptic transmission / vasoconstrictionComponentsintegral component of plasma membrane / plasma membrane
- General Function
- Serotonin receptor activity
- Specific Function
- This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
- Pfam Domain Function
- 7tm_1 (PF00001)
- Transmembrane Regions
- 84-104 118-138 158-178 202-222 237-257 326-346 368-388
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0010453|5-hydroxytryptamine receptor 7 (HTR7) ATGATGGACGTTAACAGCAGCGGCCGCCCGGACCTCTACGGGCACCTCCGCTCTTTCCTT CTGCCAGAAGTGGGGCGCGGGCTGCCCGACTTGAGCCCCGACGGTGGCGCCGACCCGGTC GCGGGCTCCTGGGCGCCGCACCTGCTGAGCGAGGTGACAGCCAGCCCGGCGCCCACCTGG GACGCGCCCCCGGACAATGCCTCCGGCTGTGGGGAACAGATCAACTACGGCAGAGTCGAG AAAGTTGTGATCGGCTCCATCCTGACGCTCATCACGCTGCTGACGATCGCGGGCAACTGC CTGGTGGTGATCTCCGTGTGCTTCGTCAAGAAGCTCCGCCAGCCCTCCAACTACCTGATC GTGTCCCTGGCGCTGGCCGACCTCTCGGTGGCTGTGGCGGTCATGCCCTTCGTCAGCGTC ACCGACCTCATCGGGGGCAAGTGGATCTTTGGACACTTTTTCTGTAATGTCTTCATCGCC ATGGACGTCATGTGCTGCACGGCCTCGATCATGACCCTGTGCGTGATCAGCATTGACAGG TACCTTGGGATCACAAGGCCCCTCACATACCCTGTGAGGCAGAATGGGAAATGCATGGCG AAGATGATTCTCTCCGTCTGGCTTCTCTCCGCCTCCATCACCTTACCTCCACTCTTTGGA TGGGCTCAGAATGTAAATGATGATAAGGTGTGCTTGATCAGCCAGGACTTTGGCTATACG ATTTACTCTACCGCAGTGGCATTTTATATCCCCATGTCCGTCATGCTTTTCATGTACTAC CAGATTTACAAGGCTGCCAGGAAGAGTGCTGCCAAACACAAGTTTCCTGGCTTCCCTCGA GTGGAGCCAGACAGCGTCATCGCCCTGAATGGCATAGTGAAGCTCCAGAAGGAGGTGGAA GAGTGTGCAAACCTTTCGAGACTCCTCAAGCATGAAAGGAAAAACATCTCCATCTTTAAG CGAGAACAGAAAGCAGCCACCACCCTGGGGATCATCGTCGGGGCCTTTACCGTGTGCTGG CTGCCATTTTTCCTCCTCTCGACAGCCAGACCCTTCATCTGTGGCACTTCCTGCAGCTGC ATCCCACTGTGGGTGGAGAGGACATTTCTGTGGCTAGGCTATGCAAACTCTCTCATTAAC CCTTTTATATATGCCTTCTTCAACCGGGACCTGAGGACCACCTATCGCAGCCTGCTCCAG TGCCAGTACCGGAATATCAACCGGAAGCTCTCAGCTGCAGGCATGCATGAAGCCCTGAAG CTTGCTGAGAGGCCAGAGAGACCTGAGTTTGTGCTACAAAATGCTGACTACTGTAGAAAA AAAGGTCATGATTCATGA
- Chromosome Location
- 10
- Locus
- 10q21-q24
- External Identifiers
Resource Link UniProtKB ID P34969 UniProtKB Entry Name 5HT7R_HUMAN GenBank Protein ID 1857143 GenBank Gene ID U68487 GenAtlas ID HTR7 HGNC ID HGNC:5302 - General References
- Heidmann DE, Metcalf MA, Kohen R, Hamblin MW: Four 5-hydroxytryptamine7 (5-HT7) receptor isoforms in human and rat produced by alternative splicing: species differences due to altered intron-exon organization. J Neurochem. 1997 Apr;68(4):1372-81. [Article]
- Bard JA, Zgombick J, Adham N, Vaysse P, Branchek TA, Weinshank RL: Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase. J Biol Chem. 1993 Nov 5;268(31):23422-6. [Article]
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00246 Ziprasidone approved unknown antagonist Details DB00247 Methysergide approved yes antagonist Details DB06216 Asenapine approved unknown antagonist Details DB01200 Bromocriptine approved, investigational, withdrawn unknown antagonist Details DB00751 Epinastine approved, investigational unknown antagonist Details DB00363 Clozapine approved unknown antagonist Details DB01238 Aripiprazole approved, investigational unknown antagonistpartial agonist Details DB01224 Quetiapine approved unknown ligand Details DB00248 Cabergoline approved unknown antagonist Details DB06288 Amisulpride approved, investigational yes antagonist Details DB04946 Iloperidone approved unknown antagonist Details DB08815 Lurasidone approved, investigational unknown antagonist Details DB00477 Chlorpromazine approved, investigational, vet_approved unknown binder Details DB00408 Loxapine approved unknown binder Details DB00458 Imipramine approved unknown antagonist Details DB00543 Amoxapine approved unknown antagonist Details DB00988 Dopamine approved unknown binder Details DB00321 Amitriptyline approved unknown antagonist Details DB00934 Maprotiline approved, investigational unknown antagonist Details DB06148 Mianserin approved, investigational unknown antagonist Details DB09068 Vortioxetine approved, investigational yes antagonist Details DB00589 Lisuride approved, investigational unknown Details DB01267 Paliperidone approved unknown Details DB00434 Cyproheptadine approved unknown antagonist Details DB13988 SB-269970 investigational unknown antagonist Details DB09225 Zotepine approved, investigational, withdrawn yes antagonist Details DB04948 Lofexidine approved, investigational no agonist Details DB14185 Aripiprazole lauroxil approved, investigational unknown Details DB00502 Haloperidol approved unknown Details DB00924 Cyclobenzaprine approved unknown antagonist Details DB00734 Risperidone approved, investigational unknown antagonist Details DB00315 Zolmitriptan approved, investigational no agonist Details DB00953 Rizatriptan approved unknown agonist Details DB09128 Brexpiprazole approved, investigational unknown antagonist Details DB13025 Tiapride investigational yes antagonist Details DB09304 Setiptiline experimental unknown antagonist Details DB13345 Dihydroergocristine approved, experimental yes antagonist Details DB01049 Ergoloid mesylate approved yes antagonistagonist Details DB11273 Dihydroergocornine approved yes antagonistagonist Details DB12141 Gilteritinib approved, investigational no inhibitor Details DB00715 Paroxetine approved, investigational unknown Details DB01239 Chlorprothixene approved, experimental, investigational, withdrawn yes inhibitor Details