Interleukin-13
Details
- Name
- Interleukin-13
- Synonyms
- IL-13
- NC30
- Gene Name
- IL13
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0037206|Interleukin-13 MHPLLNPLLLALGLMALLLTTVIALTCLGGFASPGPVPPSTALRELIEELVNITQNQKAP LCNGSMVWSINLTAGMYCAALESLINVSGCSAIEKTQRMLSGFCPHKVSAGQFSSLHVRD TKIEVAQFVKDLLLHLKKLFREGRFN
- Number of residues
- 146
- Molecular Weight
- 15815.585
- Theoretical pI
- 8.51
- GO Classification
- Functionscytokine activity / interleukin-13 receptor bindingProcessescell-cell signaling / cellular response to cytokine stimulus / cellular response to mechanical stimulus / immune response / inflammatory response / microglial cell activation / movement of cell or subcellular component / negative regulation of complement-dependent cytotoxicity / negative regulation of endothelial cell apoptotic process / negative regulation of lung ciliated cell differentiation / negative regulation of NAD(P)H oxidase activity / negative regulation of neuron death / negative regulation of transforming growth factor beta production / positive regulation of B cell proliferation / positive regulation of connective tissue growth factor production / positive regulation of immunoglobulin production / positive regulation of lung goblet cell differentiation / positive regulation of macrophage activation / positive regulation of mast cell degranulation / positive regulation of pancreatic stellate cell proliferation / positive regulation of protein secretion / positive regulation of release of sequestered calcium ion into cytosol / positive regulation of smooth muscle cell proliferation / positive regulation of tyrosine phosphorylation of Stat6 protein / regulation of proton transport / response to ethanol / response to lipopolysaccharide / response to nicotine / signal transductionComponentscytoplasm / external side of plasma membrane / extracellular region / extracellular space
- General Function
- Interleukin-13 receptor binding
- Specific Function
- Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.
- Pfam Domain Function
- IL13 (PF03487)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0020615|Interleukin-13 (IL13) ATGCATCCGCTCCTCAATCCTCTCCTGTTGGCACTGGGCCTCATGGCGCTTTTGTTGACC ACGGTCATTGCTCTCACTTGCCTTGGCGGCTTTGCCTCCCCAGGCCCTGTGCCTCCCTCT ACAGCCCTCAGGGAGCTCATTGAGGAGCTGGTCAACATCACCCAGAACCAGAAGGCTCCG CTCTGCAATGGCAGCATGGTATGGAGCATCAACCTGACAGCTGGCATGTACTGTGCAGCC CTGGAATCCCTGATCAACGTGTCAGGCTGCAGTGCCATCGAGAAGACCCAGAGGATGCTG AGCGGATTCTGCCCGCACAAGGTCTCAGCTGGGCAGTTTTCCAGCTTGCATGTCCGAGAC ACCAAAATCGAGGTGGCCCAGTTTGTAAAGGACCTGCTCTTACATTTAAAGAAACTTTTT CGCGAGGGACAGTTCAACTGA
- Chromosome Location
- 5
- Locus
- 5q31
- External Identifiers
Resource Link UniProtKB ID P35225 UniProtKB Entry Name IL13_HUMAN GenBank Gene ID X69079 GenAtlas ID IL13 HGNC ID HGNC:5973 - General References
- Minty A, Chalon P, Derocq JM, Dumont X, Guillemot JC, Kaghad M, Labit C, Leplatois P, Liauzun P, Miloux B, et al.: Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses. Nature. 1993 Mar 18;362(6417):248-50. [Article]
- McKenzie AN, Culpepper JA, de Waal Malefyt R, Briere F, Punnonen J, Aversa G, Sato A, Dang W, Cocks BG, Menon S, et al.: Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function. Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3735-9. [Article]
- Smirnov DV, Smirnova MG, Korobko VG, Frolova EI: Tandem arrangement of human genes for interleukin-4 and interleukin-13: resemblance in their organization. Gene. 1995 Apr 3;155(2):277-81. [Article]
- Dolganov G, Bort S, Lovett M, Burr J, Schubert L, Short D, McGurn M, Gibson C, Lewis DB: Coexpression of the interleukin-13 and interleukin-4 genes correlates with their physical linkage in the cytokine gene cluster on human chromosome 5q23-31. Blood. 1996 Apr 15;87(8):3316-26. [Article]
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- Morgan JG, Dolganov GM, Robbins SE, Hinton LM, Lovett M: The selective isolation of novel cDNAs encoded by the regions surrounding the human interleukin 4 and 5 genes. Nucleic Acids Res. 1992 Oct 11;20(19):5173-9. [Article]
- Moy FJ, Diblasio E, Wilhelm J, Powers R: Solution structure of human IL-13 and implication for receptor binding. J Mol Biol. 2001 Jun 29;310(1):219-30. [Article]
- Lupardus PJ, Birnbaum ME, Garcia KC: Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2. Structure. 2010 Mar 10;18(3):332-42. doi: 10.1016/j.str.2010.01.003. [Article]
- Heinzmann A, Mao XQ, Akaiwa M, Kreomer RT, Gao PS, Ohshima K, Umeshita R, Abe Y, Braun S, Yamashita T, Roberts MH, Sugimoto R, Arima K, Arinobu Y, Yu B, Kruse S, Enomoto T, Dake Y, Kawai M, Shimazu S, Sasaki S, Adra CN, Kitaichi M, Inoue H, Yamauchi K, Tomichi N, Kurimoto F, Hamasaki N, Hopkin JM, Izuhara K, Shirakawa T, Deichmann KA: Genetic variants of IL-13 signalling and human asthma and atopy. Hum Mol Genet. 2000 Mar 1;9(4):549-59. [Article]
- Howard TD, Whittaker PA, Zaiman AL, Koppelman GH, Xu J, Hanley MT, Meyers DA, Postma DS, Bleecker ER: Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population. Am J Respir Cell Mol Biol. 2001 Sep;25(3):377-84. [Article]
- Wang M, Xing ZM, Lu C, Ma YX, Yu DL, Yan Z, Wang SW, Yu LS: A common IL-13 Arg130Gln single nucleotide polymorphism among Chinese atopy patients with allergic rhinitis. Hum Genet. 2003 Oct;113(5):387-90. Epub 2003 Aug 20. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB05305 Cintredekin besudotox investigational unknown Details DB11914 Lebrikizumab approved, investigational yes antibody Details DB12169 Tralokinumab approved, investigational yes antibody Details DB12159 Dupilumab approved, investigational yes inhibitorantibody Details DB16318 Romilkimab investigational unknown inhibitor Details