Probable L-ascorbate-6-phosphate lactonase UlaG

Details

Name
Probable L-ascorbate-6-phosphate lactonase UlaG
Synonyms
  • 3.1.1.-
  • L-ascorbate utilization protein G
  • yjfR
Gene Name
ulaG
Organism
Escherichia coli (strain K12)
Amino acid sequence
>lcl|BSEQ0007803|Probable L-ascorbate-6-phosphate lactonase UlaG
MSKVKSITRESWILSTFPEWGSWLNEEIEQEQVAPGTFAMWWLGCTGIWLKSEGGTNVCV
DFWCGTGKQSHGNPLMKQGHQMQRMAGVKKLQPNLRTTPFVLDPFAIRQIDAVLATHDHN
DHIDVNVAAAVMQNCADDVPFIGPKTCVDLWIGWGVPKERCIVVKPGDVVKVKDIEIHAL
DAFDRTALITLPADQKAAGVLPDGMDDRAVNYLFKTPGGSLYHSGDSHYSNYYAKHGNEH
QIDVALGSYGENPRGITDKMTSADMLRMGEALNAKVVIPFHHDIWSNFQADPQEIRVLWE
MKKDRLKYGFKPFIWQVGGKFTWPLDKDNFEYHYPRGFDDCFTIEPDLPFKSFL
Number of residues
354
Molecular Weight
40060.435
Theoretical pI
6.19
GO Classification
Functions
L-ascorbate 6-phosphate lactonase activity / manganese ion binding
Processes
L-ascorbic acid catabolic process
Components
cytoplasm
General Function
Manganese ion binding
Specific Function
Probably catalyzes the hydrolysis of L-ascorbate-6-P into 3-keto-L-gulonate-6-P. Is essential for L-ascorbate utilization under anaerobic conditions. Also shows phosphodiesterase activity, hydrolyzing phosphodiester bond in the artificial chromogenic substrate bis-p-nitrophenyl phosphate (bis-pNPP).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0017326|Probable L-ascorbate-6-phosphate lactonase UlaG (ulaG)
ATGAGTAAAGTGAAAAGTATCACCCGTGAATCCTGGATCCTGAGCACTTTCCCGGAGTGG
GGTAGCTGGTTGAATGAAGAAATTGAACAAGAACAGGTCGCTCCTGGCACATTTGCGATG
TGGTGGCTTGGCTGCACCGGGATCTGGTTGAAATCGGAAGGTGGCACCAACGTTTGCGTT
GATTTCTGGTGCGGCACTGGCAAACAAAGTCACGGTAACCCGTTAATGAAACAGGGTCAC
CAGATGCAGCGCATGGCTGGCGTGAAAAAACTGCAGCCAAACCTGCGTACCACCCCGTTT
GTTCTTGATCCGTTTGCGATTCGCCAGATCGACGCGGTACTGGCGACTCACGATCACAAC
GATCATATCGACGTTAACGTCGCTGCTGCCGTGATGCAGAATTGTGCAGATGACGTACCG
TTTATCGGACCGAAAACCTGTGTGGATTTGTGGATTGGCTGGGGCGTACCGAAAGAGCGT
TGCATCGTGGTCAAACCGGGCGATGTAGTAAAAGTGAAAGACATTGAAATTCATGCGCTT
GATGCTTTCGACCGTACTGCACTGATCACCCTGCCTGCCGATCAAAAAGCGGCTGGCGTA
CTGCCAGATGGCATGGACGATCGCGCGGTGAACTACCTGTTCAAAACGCCTGGCGGCTCC
CTGTATCACAGCGGCGACTCCCACTACTCTAACTATTATGCGAAGCACGGTAACGAACAT
CAGATCGACGTGGCGTTAGGATCGTACGGCGAAAACCCGCGCGGTATCACCGACAAAATG
ACCAGCGCCGATATGCTGCGTATGGGTGAAGCGCTGAATGCGAAAGTAGTGATCCCGTTC
CACCACGATATCTGGTCAAACTTCCAGGCCGATCCGCAAGAGATCCGCGTGCTGTGGGAG
ATGAAAAAAGATCGCCTGAAGTATGGCTTCAAGCCGTTTATCTGGCAGGTGGGTGGCAAA
TTTACCTGGCCGCTGGATAAAGACAACTTCGAGTACCACTATCCGCGCGGTTTCGATGAT
TGCTTCACTATTGAACCGGATCTGCCGTTCAAGTCATTCCTGTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP39300
UniProtKB Entry NameULAG_ECOLI
GenBank Protein ID1263173
GenBank Gene IDU14003
General References
  1. Burland V, Plunkett G 3rd, Sofia HJ, Daniels DL, Blattner FR: Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes. Nucleic Acids Res. 1995 Jun 25;23(12):2105-19. [Article]
  2. Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. [Article]
  3. Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. Epub 2006 Feb 21. [Article]
  4. Campos E, Aguilar J, Baldoma L, Badia J: The gene yjfQ encodes the repressor of the yjfR-X regulon (ula), which is involved in L-ascorbate metabolism in Escherichia coli. J Bacteriol. 2002 Nov;184(21):6065-8. [Article]
  5. Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr: The ascorbate transporter of Escherichia coli. J Bacteriol. 2003 Apr;185(7):2243-50. [Article]
  6. Campos E, Baldoma L, Aguilar J, Badia J: Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli. J Bacteriol. 2004 Mar;186(6):1720-8. [Article]
  7. Kuznetsova E, Proudfoot M, Sanders SA, Reinking J, Savchenko A, Arrowsmith CH, Edwards AM, Yakunin AF: Enzyme genomics: Application of general enzymatic screens to discover new enzymes. FEMS Microbiol Rev. 2005 Apr;29(2):263-79. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04464N-FormylmethionineexperimentalunknownDetails