Hydroxyethylthiazole kinase

Details

Name
Hydroxyethylthiazole kinase
Synonyms
  • 2.7.1.50
  • 4-methyl-5-beta-hydroxyethylthiazole kinase
  • TH kinase
  • thiK
  • Thz kinase
  • ywbJ
Gene Name
thiM
Organism
Bacillus subtilis (strain 168)
Amino acid sequence
>lcl|BSEQ0019197|Hydroxyethylthiazole kinase
MDAQSAAKCLTAVRRHSPLVHSITNNVVTNFTANGLLALGASPVMAYAKEEVADMAKIAG
ALVLNIGTLSKESVEAMIIAGKSANEHGVPVILDPVGAGATPFRTESARDIIREVRLAAI
RGNAAEIAHTVGVTDWLIKGVDAGEGGGDIIRLAQQAAQKLNTVIAITGEVDVIADTSHV
YTLHNGHKLLTKVTGAGCLLTSVVGAFCAVEENPLFAAIAAISSYGVAAQLAAQQTADKG
PGSFQIELLNKLSTVTEQDVQEWATIERVTVS
Number of residues
272
Molecular Weight
28212.985
Theoretical pI
5.58
GO Classification
Functions
ATP binding / hydroxyethylthiazole kinase activity / magnesium ion binding
Processes
thiamine biosynthetic process / thiamine diphosphate biosynthetic process
General Function
Magnesium ion binding
Specific Function
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0019198|Hydroxyethylthiazole kinase (thiM)
ATGGATGCACAATCAGCAGCAAAATGTCTTACGGCTGTCCGCCGGCATAGCCCACTGGTG
CATAGCATAACCAACAATGTCGTAACGAATTTCACAGCAAACGGCCTGCTCGCGCTCGGC
GCATCGCCCGTTATGGCGTACGCAAAAGAAGAGGTCGCCGATATGGCGAAAATTGCGGGT
GCACTCGTTTTAAATATCGGAACACTGAGCAAGGAGTCAGTCGAAGCGATGATCATCGCG
GGAAAATCAGCTAATGAACATGGCGTTCCCGTCATTCTTGATCCTGTCGGTGCCGGAGCA
ACACCGTTCCGCACTGAATCGGCACGTGACATCATTCGTGAGGTGCGCCTTGCTGCAATC
AGAGGAAATGCGGCGGAAATTGCCCATACCGTCGGCGTGACCGATTGGCTGATCAAAGGT
GTTGATGCGGGTGAAGGTGGAGGCGACATCATCCGGCTGGCTCAGCAGGCGGCACAAAAG
CTAAACACGGTCATTGCGATAACTGGTGAAGTTGATGTCATAGCCGACACGTCACATGTA
TACACCCTTCATAACGGCCACAAGCTGCTGACAAAAGTGACAGGCGCCGGTTGCCTGCTG
ACTTCCGTCGTCGGTGCGTTTTGCGCTGTGGAAGAAAATCCATTGTTTGCTGCTATTGCG
GCCATTTCTTCGTATGGGGTCGCCGCTCAGCTTGCCGCACAGCAGACGGCTGACAAAGGC
CCTGGAAGCTTTCAGATTGAATTGCTGAACAAGCTTTCAACTGTTACTGAACAAGACGTC
CAAGAATGGGCGACTATAGAAAGGGTGACTGTCTCATGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP39593
UniProtKB Entry NameTHIM_BACSU
GenBank Gene IDX73124
General References
  1. Glaser P, Kunst F, Arnaud M, Coudart MP, Gonzales W, Hullo MF, Ionescu M, Lubochinsky B, Marcelino L, Moszer I, et al.: Bacillus subtilis genome project: cloning and sequencing of the 97 kb region from 325 degrees to 333 degrees. Mol Microbiol. 1993 Oct;10(2):371-84. [Article]
  2. Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G, Azevedo V, Bertero MG, Bessieres P, Bolotin A, Borchert S, Borriss R, Boursier L, Brans A, Braun M, Brignell SC, Bron S, Brouillet S, Bruschi CV, Caldwell B, Capuano V, Carter NM, Choi SK, Cordani JJ, Connerton IF, Cummings NJ, Daniel RA, Denziot F, Devine KM, Dusterhoft A, Ehrlich SD, Emmerson PT, Entian KD, Errington J, Fabret C, Ferrari E, Foulger D, Fritz C, Fujita M, Fujita Y, Fuma S, Galizzi A, Galleron N, Ghim SY, Glaser P, Goffeau A, Golightly EJ, Grandi G, Guiseppi G, Guy BJ, Haga K, Haiech J, Harwood CR, Henaut A, Hilbert H, Holsappel S, Hosono S, Hullo MF, Itaya M, Jones L, Joris B, Karamata D, Kasahara Y, Klaerr-Blanchard M, Klein C, Kobayashi Y, Koetter P, Koningstein G, Krogh S, Kumano M, Kurita K, Lapidus A, Lardinois S, Lauber J, Lazarevic V, Lee SM, Levine A, Liu H, Masuda S, Mauel C, Medigue C, Medina N, Mellado RP, Mizuno M, Moestl D, Nakai S, Noback M, Noone D, O'Reilly M, Ogawa K, Ogiwara A, Oudega B, Park SH, Parro V, Pohl TM, Portelle D, Porwollik S, Prescott AM, Presecan E, Pujic P, Purnelle B, Rapoport G, Rey M, Reynolds S, Rieger M, Rivolta C, Rocha E, Roche B, Rose M, Sadaie Y, Sato T, Scanlan E, Schleich S, Schroeter R, Scoffone F, Sekiguchi J, Sekowska A, Seror SJ, Serror P, Shin BS, Soldo B, Sorokin A, Tacconi E, Takagi T, Takahashi H, Takemaru K, Takeuchi M, Tamakoshi A, Tanaka T, Terpstra P, Togoni A, Tosato V, Uchiyama S, Vandebol M, Vannier F, Vassarotti A, Viari A, Wambutt R, Wedler H, Weitzenegger T, Winters P, Wipat A, Yamamoto H, Yamane K, Yasumoto K, Yata K, Yoshida K, Yoshikawa HF, Zumstein E, Yoshikawa H, Danchin A: The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature. 1997 Nov 20;390(6657):249-56. [Article]
  3. Zhang Y, Taylor SV, Chiu HJ, Begley TP: Characterization of the Bacillus subtilis thiC operon involved in thiamine biosynthesis. J Bacteriol. 1997 May;179(9):3030-5. [Article]
  4. Campobasso N, Mathews II, Begley TP, Ealick SE: Crystal structure of 4-methyl-5-beta-hydroxyethylthiazole kinase from Bacillus subtilis at 1.5 A resolution. Biochemistry. 2000 Jul 11;39(27):7868-77. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB029695-(2-hydroxyethyl)-4-methylthiazoleexperimentalunknownDetails