Endothelin-converting enzyme 1

Details

Name

Endothelin-converting enzyme 1

Synonyms

• 3.4.24.71
• ECE-1

Gene Name

ECE1

Organism

Humans

Amino acid sequence

>lcl|BSEQ0007276|Endothelin-converting enzyme 1
MRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWA
ARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVD
PCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQV
YYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVY
VSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAI
RPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVE
INESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEV
MYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLS
TLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNF
SWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGG
IGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVN
GRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTP
ESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW

Number of residues

770

Molecular Weight

87162.975

Theoretical pI

5.68

GO Classification

Functions

endopeptidase activity / metal ion binding / metalloendopeptidase activity / peptide hormone binding / protein homodimerization activity

Processes

bradykinin catabolic process / calcitonin catabolic process / ear development / embryonic digit morphogenesis / endothelin maturation / heart development / hormone catabolic process / peptide hormone processing / pharyngeal system development / positive regulation of receptor recycling / protein processing / regulation of systemic arterial blood pressure by endothelin / regulation of vasoconstriction / substance P catabolic process

Components

early endosome / endosome / external side of plasma membrane / extracellular exosome / integral component of membrane / intrinsic component of endosome membrane / lysosomal membrane / membrane / perinuclear region of cytoplasm / plasma membrane / vesicle / Weibel-Palade body

General Function

Protein homodimerization activity

Specific Function

Converts big endothelin-1 to endothelin-1.

Pfam Domain Function

• Peptidase_M13 (PF01431)
• Peptidase_M13_N (PF05649)

Transmembrane Regions

69-89

Cellular Location

Cell membrane

Gene sequence

>lcl|BSEQ0012646|Endothelin-converting enzyme 1 (ECE1)
ATGCCTCTCCAGGGCCTGGGCCTGCAGCGGAACCCCTTCCTCCAAGGGAAGCGGGGCCCG
GGGCTCACGTCTTCCCCGCCCCTCCTGCCTCCTTCCCTGCAGGTGAACTTCCACAGCCCC
CGGAGTGGCCAGAGGTGCTGGGCTGCACGGACCCAGGTGGAGAAGCGGCTGGTGGTGTTG
GTGGTACTTCTGGCGGCAGGACTGGTGGCCTGCTTGGCAGCACTGGGCATCCAGTACCAG
ACAAGATCCCCCTCTGTGTGCCTGAGCGAAGCTTGTGTCTCAGTGACCAGCTCCATCTTG
AGCTCCATGGACCCCACAGTGGACCCCTGCCATGACTTCTTCAGCTACGCCTGTGGGGGC
TGGATCAAGGCCAACCCAGTCCCTGATGGCCACTCACGCTGGGGGACCTTCAGCAACCTC
TGGGAACACAACCAAGCAATCATCAAGCACCTCCTCGAAAACTCCACGGCCAGCGTGAGC
GAGGCAGAGAGAAAGGCGCAAGTATACTACCGTGCGTGCATGAACGAGACCAGGATCGAG
GAGCTCAGGGCCAAACCTCTAATGGAGTTGATTGAGAGGCTCGGGGGCTGGAACATCACA
GGTCCCTGGGCCAAGGACAACTTCCAGGACACCCTGCAGGTGGTCACCGCCCACTACCGC
ACCTCACCCTTCTTCTCTGTCTATGTCAGTGCCGATTCCAAGAACTCCAACAGCAACGTG
ATCCAGGTGGACCAGTCTGGCCTGGGCTTGCCCTCGAGAGACTATTACCTGAACAAAACT
GAAAACGAGAAGGTGCTGACCGGATATCTGAACTACATGGTCCAGCTGGGGAAGCTGCTG
GGCGGCGGGGACGAGGAGGCCATCCGGCCCCAGATGCAGCAGATCTTGGACTTTGAGACG
GCACTGGCCAACATCACCATCCCACAGGAGAAGCGCCGTGATGAGGAGCTCATCTACCAC
AAAGTGACGGCAGCCGAGCTGCAGACCTTGGCACCCGCCATCAACTGGTTGCCTTTTCTC
AACACCATCTTCTACCCCGTGGAGATCAATGAATCCGAGCCTATTGTGGTCTATGACAAG
GAATACCTTGAGCAGATCTCCACTCTCATCAACACCACCGACAGATGCCTGCTCAACAAC
TACATGATCTGGAACCTGGTGCGGAAAACAAGCTCCTTCCTTGACCAGCGCTTTCAGGAC
GCCGATGAGAAGTTCATGGAAGTCATGTACGGGACCAAGAAGACCTGTCTTCCTCGCTGG
AAGTTTTGCGTGAGTGACACAGAAAACAACCTGGGCTTTGCGTTGGGCCCCATGTTTGTC
AAAGCAACCTTCGCCGAGGACAGCAAGAGCATAGCCACCGAGATCATCCTGGAGATTAAG
AAGGCATTTGAGGAAAGCCTGAGCACCCTGAAGTGGATGGATGAGGAAACCCGAAAATCA
GCCAAGGAAAAGGCCGATGCCATCTACAACATGATAGGATACCCCAACTTCATCATGGAT
CCCAAGGAGCTGGACAAAGTGTTTAATGACTACACTGCAGTTCCAGACCTCTACTTTGAA
AATGCCATGCGGTTTTTCAACTTCTCATGGAGGGTCACTGCCGATCAGCTCAGGAAAGCC
CCCAACAGAGATCAGTGGAGCATGACCCCGCCCATGGTGAACGCCTACTACTCGCCCACC
AAGAATGAGATTGTGTTTCCGGCCGGGATCCTGCAGGCACCATTCTACACACGCTCCTCA
CCCAAGGCCTTAAACTTTGGTGGCATAGGTGTCGTCGTGGGCCATGAGCTGACTCATGCT
TTTGATGATCAAGGACGGGAGTATGACAAGGACGGGAACCTCCGGCCATGGTGGAAGAAC
TCATCCGTGGAGGCCTTCAAGCGTCAGACCGAGTGCATGGTAGAGCAGTACAGCAACTAC
AGCGTGAACGGGGAGCCGGTGAACGGGCGGCACACCCTGGGGGAGAACATCGCCGACAAC
GGGGGTCTCAAGGCGGCCTATCGGGCTTACCAGAACTGGGTGAAGAAGAACGGGGCTGAG
CACTCGCTCCCCACCCTGGGCCTCACCAATAACCAGCTCTTCTTCCTGGGCTTTGCACAG
GTCTGGTGCTCCGTCCGCACACCTGAGAGCTCCCACGAAGGCCTCATCACCGATCCCCAC
AGCCCCTCTCGCTTCCGGGTCATCGGCTCCCTCTCCAATTCCAAGGAGTTCTCAGAACAC
TTCCGCTGCCCACCTGGCTCACCCATGAACCCGCCTCACAAGTGCGAAGTCTGGTAA

Chromosome Location

1

Locus

1p36.1

External Identifiers

Resource	Link
UniProtKB ID	P42892
UniProtKB Entry Name	ECE1_HUMAN
GenBank Protein ID	695405
GenBank Gene ID	D49471
HGNC ID	HGNC:3146

General References

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2. Shimada K, Matsushita Y, Wakabayashi K, Takahashi M, Matsubara A, Iijima Y, Tanzawa K: Cloning and functional expression of human endothelin-converting enzyme cDNA. Biochem Biophys Res Commun. 1995 Feb 15;207(2):807-12. [Article]
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Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB07171	5-(2-hydroxyethyl)nonane-1,9-diol	experimental	unknown		Details