Prostaglandin F2-alpha receptor
Details
- Name
- Prostaglandin F2-alpha receptor
- Synonyms
- PGF receptor
- Prostanoid FP receptor
- Gene Name
- PTGFR
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0001217|Prostaglandin F2-alpha receptor MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQ KSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGL CPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQ ASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQG RSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFALRMATWNQILD PWVYILLRKAVLKNLYKLASQCCGVHVISLHIWELSSIKNSLKVAAISESPVAEKSAST
- Number of residues
- 359
- Molecular Weight
- 40054.1
- Theoretical pI
- 9.11
- GO Classification
- Functionsprostaglandin F receptor activityProcessescalcium-mediated signaling using intracellular calcium source / cellular response to prostaglandin D stimulus / G-protein coupled receptor signaling pathway / negative regulation of apoptotic process / parturition / positive regulation of cell proliferation / positive regulation of gene expression / response to estradiol / response to lipopolysaccharideComponentscytoplasm / extracellular region / integral component of plasma membrane / plasma membrane
- General Function
- Prostaglandin f receptor activity
- Specific Function
- Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost.
- Pfam Domain Function
- 7tm_1 (PF00001)
- Transmembrane Regions
- 32-54 70-90 110-131 153-175 199-224 251-267 286-307
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0016151|Prostaglandin F2-alpha receptor (PTGFR) ATGTCCATGAACAATTCCAAACAGCTAGTGTCTCCTGCAGCTGCGCTTCTTTCAAACACA ACCTGCCAGACGGAAAACCGGCTTTCCGTATTTTTTTCAGTAATCTTCATGACAGTGGGA ATCTTGTCAAACAGCCTTGCCATCGCCATTCTCATGAAGGCATATCAGAGATTTAGACAG AAGTCCAAGGCATCGTTTCTGCTTTTGGCCAGTGGCCTGGTAATCACTGATTTCTTTGGC CATCTCATCAATGGAGCCATAGCAGTATTTGTATATGCTTCTGATAAAGAATGGATCCGC TTTGACCAATCAAATGTCCTTTGCAGTATTTTTGGTATCTGCATGGTGTTTTCTGGTCTG TGCCCACTTCTTCTAGGCAGTGTGATGGCCATTGAGCGGTGTATTGGAGTCACAAAACCA ATATTTCATTCTACGAAAATTACATCCAAACATGTGAAAATGATGTTAAGTGGTGTGTGC TTGTTTGCTGTTTTCATAGCTTTGCTGCCCATCCTTGGACATCGAGACTATAAAATTCAG GCGTCGAGGACCTGGTGTTTCTACAACACAGAAGACATCAAAGACTGGGAAGATAGATTT TATCTTCTACTTTTTTCTTTTCTGGGGCTCTTAGCCCTTGGTGTTTCATTGTTGTGCAAT GCAATCACAGGAATTACACTTTTAAGAGTTAAATTTAAAAGTCAGCAGCACAGACAAGGC AGATCTCATCATTTGGAAATGGTAATCCAGCTCCTGGCGATAATGTGTGTCTCCTGTATT TGTTGGAGCCCATTTCTGGTTACAATGGCCAACATTGGAATAAATGGAAATCATTCTCTG GAAACCTGTGAAACAACACTTTTTGCTCTCCGAATGGCAACATGGAATCAAATCTTAGAT CCTTGGGTATATATTCTTCTACGAAAGGCTGTCCTTAAGAATCTCTATAAGCTTGCCAGT CAATGCTGTGGAGTGCATGTCATCAGCTTACATATTTGGGAGCTTAGTTCCATTAAAAAT TCCTTAAAGGTTGCTGCTATTTCTGAGTCACCAGTTGCAGAGAAATCAGCAAGCACCTAG
- Chromosome Location
- 1
- Locus
- 1p31.1
- External Identifiers
Resource Link UniProtKB ID P43088 UniProtKB Entry Name PF2R_HUMAN GenBank Protein ID 456564 GenBank Gene ID L24470 GenAtlas ID PTGFR HGNC ID HGNC:9600 - General References
- Abramovitz M, Boie Y, Nguyen T, Rushmore TH, Bayne MA, Metters KM, Slipetz DM, Grygorczyk R: Cloning and expression of a cDNA for the human prostanoid FP receptor. J Biol Chem. 1994 Jan 28;269(4):2632-6. [Article]
- Kunapuli P, Lawson JA, Rokach J, FitzGerald GA: Functional characterization of the ocular prostaglandin f2alpha (PGF2alpha) receptor. Activation by the isoprostane, 12-iso-PGF2alpha. J Biol Chem. 1997 Oct 24;272(43):27147-54. [Article]
- Vielhauer GA, Fujino H, Regan JW: Cloning and localization of hFP(S): a six-transmembrane mRNA splice variant of the human FP prostanoid receptor. Arch Biochem Biophys. 2004 Jan 15;421(2):175-85. [Article]
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00287 Travoprost approved yes agonist Details DB00654 Latanoprost approved, investigational yes agonist Details DB00905 Bimatoprost approved, investigational yes agonist Details DB01160 Dinoprost tromethamine approved, vet_approved yes agonist Details DB08819 Tafluprost approved yes agonist Details DB11660 Latanoprostene bunod approved, investigational yes agonist Details