Prostaglandin F2-alpha receptor

Details

Name
Prostaglandin F2-alpha receptor
Synonyms
  • PGF receptor
  • Prostanoid FP receptor
Gene Name
PTGFR
Organism
Humans
Amino acid sequence
>lcl|BSEQ0001217|Prostaglandin F2-alpha receptor
MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQ
KSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGL
CPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQ
ASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQG
RSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFALRMATWNQILD
PWVYILLRKAVLKNLYKLASQCCGVHVISLHIWELSSIKNSLKVAAISESPVAEKSAST
Number of residues
359
Molecular Weight
40054.1
Theoretical pI
9.11
GO Classification
Functions
prostaglandin F receptor activity
Processes
calcium-mediated signaling using intracellular calcium source / cellular response to prostaglandin D stimulus / G-protein coupled receptor signaling pathway / negative regulation of apoptotic process / parturition / positive regulation of cell proliferation / positive regulation of gene expression / response to estradiol / response to lipopolysaccharide
Components
cytoplasm / extracellular region / integral component of plasma membrane / plasma membrane
General Function
Prostaglandin f receptor activity
Specific Function
Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost.
Pfam Domain Function
Transmembrane Regions
32-54 70-90 110-131 153-175 199-224 251-267 286-307
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0016151|Prostaglandin F2-alpha receptor (PTGFR)
ATGTCCATGAACAATTCCAAACAGCTAGTGTCTCCTGCAGCTGCGCTTCTTTCAAACACA
ACCTGCCAGACGGAAAACCGGCTTTCCGTATTTTTTTCAGTAATCTTCATGACAGTGGGA
ATCTTGTCAAACAGCCTTGCCATCGCCATTCTCATGAAGGCATATCAGAGATTTAGACAG
AAGTCCAAGGCATCGTTTCTGCTTTTGGCCAGTGGCCTGGTAATCACTGATTTCTTTGGC
CATCTCATCAATGGAGCCATAGCAGTATTTGTATATGCTTCTGATAAAGAATGGATCCGC
TTTGACCAATCAAATGTCCTTTGCAGTATTTTTGGTATCTGCATGGTGTTTTCTGGTCTG
TGCCCACTTCTTCTAGGCAGTGTGATGGCCATTGAGCGGTGTATTGGAGTCACAAAACCA
ATATTTCATTCTACGAAAATTACATCCAAACATGTGAAAATGATGTTAAGTGGTGTGTGC
TTGTTTGCTGTTTTCATAGCTTTGCTGCCCATCCTTGGACATCGAGACTATAAAATTCAG
GCGTCGAGGACCTGGTGTTTCTACAACACAGAAGACATCAAAGACTGGGAAGATAGATTT
TATCTTCTACTTTTTTCTTTTCTGGGGCTCTTAGCCCTTGGTGTTTCATTGTTGTGCAAT
GCAATCACAGGAATTACACTTTTAAGAGTTAAATTTAAAAGTCAGCAGCACAGACAAGGC
AGATCTCATCATTTGGAAATGGTAATCCAGCTCCTGGCGATAATGTGTGTCTCCTGTATT
TGTTGGAGCCCATTTCTGGTTACAATGGCCAACATTGGAATAAATGGAAATCATTCTCTG
GAAACCTGTGAAACAACACTTTTTGCTCTCCGAATGGCAACATGGAATCAAATCTTAGAT
CCTTGGGTATATATTCTTCTACGAAAGGCTGTCCTTAAGAATCTCTATAAGCTTGCCAGT
CAATGCTGTGGAGTGCATGTCATCAGCTTACATATTTGGGAGCTTAGTTCCATTAAAAAT
TCCTTAAAGGTTGCTGCTATTTCTGAGTCACCAGTTGCAGAGAAATCAGCAAGCACCTAG
Chromosome Location
1
Locus
1p31.1
External Identifiers
ResourceLink
UniProtKB IDP43088
UniProtKB Entry NamePF2R_HUMAN
GenBank Protein ID456564
GenBank Gene IDL24470
GenAtlas IDPTGFR
HGNC IDHGNC:9600
General References
  1. Abramovitz M, Boie Y, Nguyen T, Rushmore TH, Bayne MA, Metters KM, Slipetz DM, Grygorczyk R: Cloning and expression of a cDNA for the human prostanoid FP receptor. J Biol Chem. 1994 Jan 28;269(4):2632-6. [Article]
  2. Kunapuli P, Lawson JA, Rokach J, FitzGerald GA: Functional characterization of the ocular prostaglandin f2alpha (PGF2alpha) receptor. Activation by the isoprostane, 12-iso-PGF2alpha. J Biol Chem. 1997 Oct 24;272(43):27147-54. [Article]
  3. Vielhauer GA, Fujino H, Regan JW: Cloning and localization of hFP(S): a six-transmembrane mRNA splice variant of the human FP prostanoid receptor. Arch Biochem Biophys. 2004 Jan 15;421(2):175-85. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00287TravoprostapprovedyesagonistDetails
DB00654Latanoprostapproved, investigationalyesagonistDetails
DB00905Bimatoprostapproved, investigationalyesagonistDetails
DB01160Dinoprost tromethamineapproved, vet_approvedyesagonistDetails
DB08819TafluprostapprovedyesagonistDetails
DB11660Latanoprostene bunodapproved, investigationalyesagonistDetails