Peptide deformylase

Details

Name
Peptide deformylase
Synonyms
  • 3.5.1.88
  • PDF
  • Polypeptide deformylase
Gene Name
def
Organism
Thermus thermophilus
Amino acid sequence
>lcl|BSEQ0017004|Peptide deformylase
MVYPIRLYGDPVLRRKARPVEDFSGIKRLAEDMLETMFEAKGVGLAAPQIGLSQRLFVAV
EYADEPEGEEERPLRELVRRVYVVANPVITYREGLVEGTEGCLSLPGLYSEEVPRAERIR
VEYQDEEGRGRVLELEGYMARVFQHEIDHLDGILFFERLPKPKREAFLEANRAELVRFQK
EARALLKELSQG
Number of residues
192
Molecular Weight
22092.115
Theoretical pI
4.86
GO Classification
Functions
iron ion binding / peptide deformylase activity
Processes
translation
General Function
Peptide deformylase activity
Specific Function
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0006128|579 bp
ATGGTCTACCCCATCCGGCTTTACGGAGACCCCGTCCTCCGCCGCAAGGCCCGGCCCGTG
GAGGACTTCTCGGGGATTAAGCGCCTGGCGGAGGACATGCTGGAGACGATGTTTGAGGCC
AAAGGGGTGGGGCTTGCCGCCCCCCAGATCGGCCTCTCCCAGCGCCTCTTCGTGGCGGTG
GAGTACGCCGACGAGCCCGAGGGGGAGGAGGAGAGGCCCCTGAGGGAGCTCGTGCGCCGG
GTCTACGTGGTGGCGAACCCGGTGATCACCTACCGGGAGGGACTGGTGGAGGGGACGGAG
GGGTGCCTCTCCCTGCCCGGCCTCTACTCCGAGGAGGTGCCCCGGGCGGAGCGCATCCGG
GTGGAGTACCAGGACGAGGAGGGCCGTGGGCGCGTGTTGGAGCTCGAGGGGTACATGGCC
CGGGTCTTCCAGCATGAGATCGACCATCTGGACGGGATCCTCTTCTTTGAGCGCCTGCCC
AAGCCCAAGCGGGAGGCCTTTCTGGAGGCCAACCGGGCGGAGCTCGTCCGCTTCCAGAAG
GAGGCCCGGGCCTTGCTGAAGGAGCTTTCCCAGGGATGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP43522
UniProtKB Entry NameDEF_THETH
GenBank Gene IDX79087
General References
  1. Meinnel T, Blanquet S: Characterization of the Thermus thermophilus locus encoding peptide deformylase and methionyl-tRNA(fMet) formyltransferase. J Bacteriol. 1994 Dec;176(23):7387-90. [Article]
  2. Meinnel T, Lazennec C, Villoing S, Blanquet S: Structure-function relationships within the peptide deformylase family. Evidence for a conserved architecture of the active site involving three conserved motifs and a metal ion. J Mol Biol. 1997 Apr 4;267(3):749-61. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB03661L-cysteic acidexperimentalunknownDetails