Excitatory amino acid transporter 4
Details
- Name
- Excitatory amino acid transporter 4
- Synonyms
- EAAT4
- Sodium-dependent glutamate/aspartate transporter
- Solute carrier family 1 member 6
- Gene Name
- SLC1A6
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0004456|Excitatory amino acid transporter 4 MSSHGNSLFLRESGQRLGRVGWLQRLQESLQQRALRTRLRLQTMTLEHVLRFLRRNAFIL LTVSAVVIGVSLAFALRPYQLTYRQIKYFSFPGELLMRMLQMLVLPLIVSSLVTGMASLD NKATGRMGMRAAVYYMVTTIIAVFIGILMVTIIHPGKGSKEGLHREGRIETIPTADAFMD LIRNMFPPNLVEACFKQFKTQYSTRVVTRTMVRTENGSEPGASMPPPFSVENGTSFLENV TRALGTLQEMLSFEETVPVPGSANGINALGLVVFSVAFGLVIGGMKHKGRVLRDFFDSLN EAIMRLVGIIIWYAPVGILFLIAGKILEMEDMAVLGGQLGMYTLTVIVGLFLHAGIVLPL IYFLVTHRNPFPFIGGMLQALITAMGTSSSSATLPITFRCLEEGLGVDRRITRFVLPVGA TVNMDGTALYEALAAIFIAQVNNYELNLGQITTISITATAASVGAAGIPQAGLVTMVIVL TSVGLPTEDITLIIAVDWFLDRLRTMTNVLGDSIGAAVIEHLSQRELELQEAELTLPSLG KPYKSLMAQEKGASRGRGGNESAM
- Number of residues
- 564
- Molecular Weight
- 61564.875
- Theoretical pI
- 9.54
- GO Classification
- FunctionsL-aspartate transmembrane transporter activity / L-glutamate transmembrane transporter activity / sodiumProcessesaspartate transport / glutamate secretion / ion transport / L-aspartate transmembrane transport / L-glutamate transport / neurotransmitter secretion / regulation of membrane potential / synaptic transmission / transmembrane transportComponentsGolgi apparatus / integral component of plasma membrane / membrane / plasma membrane
- General Function
- Sodium:dicarboxylate symporter activity
- Specific Function
- Transports L-glutamate and also L- and D-aspartate. Seems to act as a symport by cotransporting sodium.
- Pfam Domain Function
- SDF (PF00375)
- Transmembrane Regions
- 56-76 99-119 133-153 265-285 306-326 345-365 370-390 418-438 460-480 481-501
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0011633|Excitatory amino acid transporter 4 (SLC1A6) ATGAGCAGCCATGGCAACAGCCTGTTCCTGCGGGAGAGCGGCCAGCGGCTGGGCCGGGTG GGCTGGCTGCAGCGGCTGCAGGAAAGCCTGCAGCAGAGAGCACTGCGCACGCGCCTGCGC CTGCAGACCATGACCCTCGAGCACGTGCTGCGCTTCCTGCGCCGAAACGCCTTCATTCTG CTGACGGTCAGCGCCGTGGTCATTGGGGTCAGCCTGGCCTTTGCCCTGCGCCCATATCAG CTCACCTACCGCCAGATCAAGTACTTCTCTTTTCCTGGAGAGCTTCTGATGAGGATGCTG CAGATGCTGGTGTTACCTCTCATTGTCTCCAGCCTGGTCACAGGTATGGCATCCCTGGAC AACAAGGCCACGGGGCGGATGGGGATGCGGGCAGCTGTGTACTACATGGTGACCACCATC ATCGCGGTCTTCATCGGCATCCTCATGGTCACCATCATCCATCCCGGGAAGGGCTCCAAG GAGGGGCTGCACCGGGAGGGCCGGATCGAGACCATCCCCACAGCTGATGCCTTCATGGAC CTGATCAGAAATATGTTTCCACCAAACCTTGTGGAGGCCTGCTTCAAACAGTTCAAGACG CAGTACAGCACGAGGGTGGTAACCAGGACCATGGTGAGGACAGAGAACGGGTCTGAGCCG GGTGCCTCCATGCCTCCTCCATTCTCAGTGGAGAACGGAACCAGCTTCCTGGAAAATGTC ACTCGGGCCTTGGGTACCCTGCAGGAGATGCTGAGCTTTGAGGAGACTGTACCCGTGCCT GGCTCCGCCAATGGCATCAACGCCCTGGGCCTCGTGGTCTTCTCTGTGGCCTTTGGGCTG GTCATTGGTGGCATGAAACACAAGGGCAGAGTCCTCAGGGACTTCTTCGACAGCCTCAAT GAGGCTATTATGAGGCTGGTGGGCATCATTATCTGGTGA
- Chromosome Location
- 19
- Locus
- 19p13.12
- External Identifiers
Resource Link UniProtKB ID P48664 UniProtKB Entry Name EAA4_HUMAN GenBank Protein ID 930337 GenBank Gene ID U18244 GenAtlas ID SLC1A6 HGNC ID HGNC:10944 - General References
- Fairman WA, Vandenberg RJ, Arriza JL, Kavanaugh MP, Amara SG: An excitatory amino-acid transporter with properties of a ligand-gated chloride channel. Nature. 1995 Jun 15;375(6532):599-603. [Article]
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