Vascular endothelial growth factor B
Details
- Name
- Vascular endothelial growth factor B
- Synonyms
- VEGF-B
- VEGF-related factor
- VRF
- Gene Name
- VEGFB
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0008587|Vascular endothelial growth factor B MSPLLRRLLLAALLQLAPAQAPVSQPDAPGHQRKVVSWIDVYTRATCQPREVVVPLTVEL MGTVAKQLVPSCVTVQRCGGCCPDDGLECVPTGQHQVRMQILMIRYPSSQLGEMSLEEHS QCECRPKKKDSAVKPDRAATPHHRPQPRSVPGWDSAPGAPSPADITHPTPAPGPSAHAAP STTSALTPGPAAAAADAAASSVAKGGA
- Number of residues
- 207
- Molecular Weight
- 21601.56
- Theoretical pI
- Not Available
- GO Classification
- Functionschemoattractant activity / heparin binding / vascular endothelial growth factor receptor 1 bindingProcessesangiogenesis / blood coagulation / cardiac muscle contraction / coronary vasculature development / induction of positive chemotaxis / negative regulation of apoptotic process / negative regulation of gene expression / negative regulation of neuron apoptotic process / platelet activation / platelet degranulation / positive chemotaxis / positive regulation of cell division / positive regulation of endothelial cell proliferation / positive regulation of ERK1 and ERK2 cascade / positive regulation of mast cell chemotaxis / positive regulation of peptidyl-tyrosine phosphorylation / positive regulation of protein kinase B signaling / positive regulation of vascular endothelial growth factor receptor signaling pathway / positive regulation of vascular wound healing / protein O-linked glycosylation / response to drug / vascular endothelial growth factor receptor signaling pathwayComponentsextracellular region / extracellular space / membrane / platelet alpha granule lumen
- General Function
- Vascular endothelial growth factor receptor 1 binding
- Specific Function
- Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.
- Pfam Domain Function
- PDGF (PF00341)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0017521|Vascular endothelial growth factor B (VEGFB) ATGAGCCCTCTGCTCCGCCGCCTGCTGCTCGCCGCACTCCTGCAGCTGGCCCCCGCCCAG GCCCCTGTCTCCCAGCCTGATGCCCCTGGCCACCAGAGGAAAGTGGTGTCATGGATAGAT GTGTATACTCGCGCTACCTGCCAGCCCCGGGAGGTGGTGGTGCCCTTGACTGTGGAGCTC ATGGGCACCGTGGCCAAACAGCTGGTGCCCAGCTGCGTGACTGTGCAGCGCTGTGGTGGC TGCTGCCCTGACGATGGCCTGGAGTGTGTGCCCACTGGGCAGCACCAAGTCCGGATGCAG ATCCTCATGATCCGGTACCCGAGCAGTCAGCTGGGGGAGATGTCCCTGGAAGAACACAGC CAGTGTGAATGCAGACCTAAAAAAAAGGACAGTGCTGTGAAGCCAGACAGCCCCAGGCCC CTCTGCCCACGCTGCACCCAGCACCACCAGCGCCCTGACCCCCGGACCTGCCGCTGCCGC TGCCGACGCCGCAGCTTCCTCCGTTGCCAAGGGCGGGGCTTAGAGCTCAACCCAGACACC TGCAGGTGCCGGAAGCTGCGAAGGTGA
- Chromosome Location
- 11
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P49765 UniProtKB Entry Name VEGFB_HUMAN HGNC ID HGNC:12681 - General References
- Grimmond S, Lagercrantz J, Drinkwater C, Silins G, Townson S, Pollock P, Gotley D, Carson E, Rakar S, Nordenskjold M, Ward L, Hayward N, Weber G: Cloning and characterization of a novel human gene related to vascular endothelial growth factor. Genome Res. 1996 Feb;6(2):124-31. [Article]
- Olofsson B, Pajusola K, von Euler G, Chilov D, Alitalo K, Eriksson U: Genomic organization of the mouse and human genes for vascular endothelial growth factor B (VEGF-B) and characterization of a second splice isoform. J Biol Chem. 1996 Aug 9;271(32):19310-7. [Article]
- Olofsson B, Pajusola K, Kaipainen A, von Euler G, Joukov V, Saksela O, Orpana A, Pettersson RF, Alitalo K, Eriksson U: Vascular endothelial growth factor B, a novel growth factor for endothelial cells. Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2576-81. [Article]
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- Iyer S, Scotney PD, Nash AD, Ravi Acharya K: Crystal structure of human vascular endothelial growth factor-B: identification of amino acids important for receptor binding. J Mol Biol. 2006 May 26;359(1):76-85. Epub 2006 Apr 17. [Article]