Glycogen synthase kinase-3 alpha

Details

Name
Glycogen synthase kinase-3 alpha
Synonyms
  • 2.7.11.26
  • GSK-3 alpha
  • Serine/threonine-protein kinase GSK3A
Gene Name
GSK3A
Organism
Humans
Amino acid sequence
>lcl|BSEQ0051770|Glycogen synthase kinase-3 alpha
MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGV
GASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYT
DIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFY
SSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGV
CHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSS
IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIK
AHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLP
PLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLT
NSS
Number of residues
483
Molecular Weight
50980.41
Theoretical pI
Not Available
GO Classification
Functions
ATP binding / protein kinase A catalytic subunit binding / protein serine/threonine kinase activity / receptor binding / tau-protein kinase activity
Processes
aging / cardiac left ventricle morphogenesis / cell migration / cellular response to insulin stimulus / cellular response to interleukin-3 / cellular response to lithium ion / cellular response to organic cyclic compound / dopamine receptor signaling pathway / excitatory postsynaptic potential / extrinsic apoptotic signaling pathway / extrinsic apoptotic signaling pathway in absence of ligand / glycogen metabolic process / hypermethylation of CpG island / insulin receptor signaling pathway / IRE1-mediated unfolded protein response / negative regulation of canonical Wnt signaling pathway / negative regulation of cell growth involved in cardiac muscle cell development / negative regulation of dendrite development / negative regulation of glucose import / negative regulation of glycogen (starch) synthase activity / negative regulation of glycogen biosynthetic process / negative regulation of glycogen synthase activity, transferring glucose-1-phosphate / negative regulation of insulin receptor signaling pathway / negative regulation of TOR signaling / negative regulation of type B pancreatic cell development / negative regulation of UDP-glucose catabolic process / nervous system development / peptidyl-serine phosphorylation / peptidyl-threonine phosphorylation / positive regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway / positive regulation of adrenergic receptor signaling pathway / positive regulation of amyloid-beta formation / positive regulation of gene expression / positive regulation of glycogen (starch) synthase activity / positive regulation of heart contraction / positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway / positive regulation of neuron apoptotic process / positive regulation of peptidyl-serine phosphorylation / positive regulation of peptidyl-threonine phosphorylation / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / positive regulation of protein catabolic process / positive regulation of protein targeting to mitochondrion / positive regulation of protein ubiquitination / positive regulation of transcription by RNA polymerase II / proteasome-mediated ubiquitin-dependent protein catabolic process / protein phosphorylation / regulation of autophagy of mitochondrion / regulation of gene expression by genetic imprinting / regulation of systemic arterial blood pressure / Wnt signaling pathway
Components
apical dendrite / beta-catenin destruction complex / cytosol / microtubule / mitochondrion / neuronal cell body / postsynapse / proximal dendrite
General Function
Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation.
Specific Function
Atp binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0051771|Glycogen synthase kinase-3 alpha (GSK3A)
ATGAGCGGCGGCGGGCCTTCGGGAGGCGGCCCTGGGGGCTCGGGCAGGGCGCGGACTAGC
TCGTTCGCGGAGCCCGGCGGCGGAGGCGGAGGAGGCGGCGGCGGCCCCGGAGGCTCGGCC
TCCGGCCCAGGCGGCACCGGCGGCGGAAAGGCATCTGTCGGGGCCATGGGTGGGGGCGTC
GGGGCCTCGAGCTCCGGGGGTGGACCCGGCGGCAGCGGCGGAGGAGGCAGCGGAGGCCCC
GGCGCAGGCACTAGCTTCCCGCCGCCCGGGGTGAAGCTGGGCCGTGACAGCGGGAAGGTG
ACCACAGTCGTAGCCACTCTAGGCCAAGGCCCAGAGCGCTCCCAAGAAGTGGCTTACACG
GACATCAAAGTGATTGGCAATGGCTCATTTGGGGTCGTGTACCAGGCACGGCTGGCAGAG
ACCAGGGAACTAGTCGCCATCAAGAAGGTTCTCCAGGACAAGAGGTTCAAGAACCGAGAG
CTGCAGATCATGCGTAAGCTGGACCACTGCAATATTGTGAGGCTGAGATACTTTTTCTAC
TCCAGTGGCGAGAAGAAAGACGAGCTTTACCTAAATCTGGTGCTGGAATATGTGCCCGAG
ACAGTGTACCGGGTGGCCCGCCACTTCACCAAGGCCAAGTTGACCATCCCTATCCTCTAT
GTCAAGGTGTACATGTACCAGCTCTTCCGCAGCTTGGCCTACATCCACTCCCAGGGCGTG
TGTCACCGCGACATCAAGCCCCAGAACCTGCTGGTGGACCCTGACACTGCTGTCCTCAAG
CTCTGCGATTTTGGCAGTGCAAAGCAGTTGGTCCGAGGGGAGCCCAATGTCTCCTACATC
TGTTCTCGCTACTACCGGGCCCCAGAGCTCATCTTTGGAGCCACTGATTACACCTCATCC
ATCGATGTTTGGTCAGCTGGCTGTGTACTGGCAGAGCTCCTCTTGGGCCAGCCCATCTTC
CCTGGGGACAGTGGGGTGGACCAGCTGGTGGAGATCATCAAGGTGCTGGGAACACCAACC
CGGGAACAAATCCGAGAGATGAACCCCAACTACACGGAGTTCAAGTTCCCTCAGATTAAA
GCTCACCCCTGGACAAAGGTGTTCAAATCTCGAACGCCGCCAGAGGCCATCGCGCTCTGC
TCTAGCCTGCTGGAGTACACCCCATCCTCAAGGCTCTCCCCACTAGAGGCCTGTGCGCAC
AGCTTCTTTGATGAACTGCGATGTCTGGGAACCCAGCTGCCTAACAACCGCCCACTTCCC
CCTCTCTTCAACTTCAGTGCTGGTGAACTCTCCATCCAACCGTCTCTCAACGCCATTCTC
ATCCCTCCTCACTTGAGGTCCCCAGCGGGCACTACCACCCTCACCCCGTCCTCACAAGCT
TTAACTGAGACTCCGACCAGCTCAGACTGGCAGTCGACCGATGCCACACCTACCCTCACT
AACTCCTCCTGA
Chromosome Location
19
Locus
19q13.2
External Identifiers
ResourceLink
UniProtKB IDP49840
UniProtKB Entry NameGSK3A_HUMAN
HGNC IDHGNC:4616
General References
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  3. Nikoulina SE, Ciaraldi TP, Mudaliar S, Mohideen P, Carter L, Henry RR: Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes. Diabetes. 2000 Feb;49(2):263-71. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB12010Fostamatinibapproved, investigationalunknowninhibitorDetails