Amiloride-sensitive sodium channel subunit delta
Details
- Name
- Amiloride-sensitive sodium channel subunit delta
- Synonyms
- Delta-ENaC
- Delta-NaCH
- DNACH
- ENaCD
- Epithelial Na(+) channel subunit delta
- Nonvoltage-gated sodium channel 1 subunit delta
- SCNED
- Gene Name
- SCNN1D
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0000988|Amiloride-sensitive sodium channel subunit delta MAEHRSMDGRMEAATRGGSHLQAAAQTPPRPGPPSAPPPPPKEGHQEGLVELPASFRELL TFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHWHRPVLMAVS VHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYNVNLSKGRAALSATVPR HEPPFHLDREIRLQRLSHSGSRVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDI LALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQRPGI THGVGLVLRVEQQPHLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEV HRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEY CSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLA TLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASV LSLLELLELLLDASALTLVLGGRRLRRAWFSWPRASPASGASSIKPEASQMPPPAGGTSD DPEPSGPHLPRVMLPGVLAGVSAEESWAGPQPLETLDT
- Number of residues
- 638
- Molecular Weight
- 70214.195
- Theoretical pI
- 7.9
- GO Classification
- Functionsligand-gated sodium channel activityProcessesion transmembrane transport / response to stimulus / sensory perception of taste / sodium ion transmembrane transport / sodium ion transport / transmembrane transportComponentsactin cytoskeleton / integral component of membrane / membrane / plasma membrane
- General Function
- Ligand-gated sodium channel activity
- Specific Function
- Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
- Pfam Domain Function
- ASC (PF00858)
- Transmembrane Regions
- 87-107 531-551
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0016110|Amiloride-sensitive sodium channel subunit delta (SCNN1D) ATGAGGGCAGTGCTGTCACAGAAGACAACACCGCTCCCTCGTTACCTGTGGCCCGGCCAC CTCAGCGGCCCAAGGAGGCTCACCTGGTCATGGTGCAGTGACCACAGGACCCCCACATGC CGGGAGCTGGGTTCGCCCCACCCCACCCCCTGCACCGGGCCAGCGAGGGGATGGCCCAGA AGAGGGGGAGGACCATGTGGATTCACCAGTGCTGGACATGTGCTCTGTGGCTACCCCCTC TGCCTACTCTCTGGCCCGATACAGGGGTGTGGGACAGGCCTGGGTGACTCCAGCATGGCT TTCCTCTCCAGGACGTCACCGGTGGCAGCTGCTTCCTTCCAGAGCCGGCAGGAGGCCAGA GGCTCCATCCTGCTTCAGAGCTGCCAGCTGCCCCCGCAATGGCTGAGCACCGAAGCATGG ACGGGAGAATGGAAGCAGCCACACGGGGGGGCTCTCACCTCCAGATCGCCTGGGCCTGTG GCTCCCCAGAGGCCCTGCCACCTGAAGGGATGGCAGCACAGACCCACTCAGCACAACGCT GCCTGCAAACAGGGCCAGGCTGCAGCCCAGACGCCCCCCAGGCCGGGGCCACCATCAGCA CCACCACCACCACCCAAGGAGGGGCACCAGGAGGGGCTGGTGGAGCTGCCCGCCTCGTTC CGGGAGCTGCTCACCTTCTTCTGCACCAATGCCACCATCCACGGCGCCATCCGCCTGGTC TGCTCCCGCGGGAACCGCCTCAAGACGACGTCCTGGGGGCTGCTGTCCCTGGGAGCCCTG GTCGCGCTCTGCTGGCAGCTGGGGCTCCTCTTTGAGCGTCACTGGCACCGCCCGGTCCTC ATGGCCGTCTCTGTGCACTCGGAGCGCAAGCTGCTCCCGCTGGTCACCCTGTGTGACGGG AACCCACGTCGGCCGAGTCCGGTCCTCCGCCATCTGGAGCTGCTGGACGAGTTTGCCAGG GAGAACATTGACTCCCTGTACAACGTCAACCTCAGCAAAGGCAGAGCCGCCCTCTCCGCC ACTGTCCCCCGCCACGAGCCCCCCTTCCACCTGGACCGGGAGATCCGTCTGCAGAGGCTG AGCCACTCGGGCAGCCGGGTCAGAGTGGGGTTCAGACTGTGCAACAGCACGGGCGGCGAC TGCTTTTACCGAGGCTACACGTCAGGCGTGGCGGCTGTCCAGGACTGGTACCACTTCCAC TATGTGGATATCCTGGCCCTGCTGCCCGCGGCATGGGAGGACAGCCACGGGAGCCAGGAC GGCCACTTCGTCCTCTCCTGCAGTTACGATGGCCTGGACTGCCAGGCCCGACAGTTCCGG ACCTTCCACCACCCCACCTACGGCAGCTGCTACACGGTCGATGGCGTCTGGACAGCTCAG CGCCCCGGCATCACCCACGGAGTCGGCCTGGTCCTCAGGGTTGAGCAGCAGCCTCACCTC CCTCTGCTGTCCACGCTGGCCGGCATCAGGGTCATGGTTCACGGCCGTAACCACACGCCC TTCCTGGGGCACCACAGCTTCAGCGTCCGGCCAGGGACGGAGGCCACCATCAGCATCCGA GAGGACGAGGTGCACCGGCTCGGGAGCCCCTACGGCCACTGCACCGCCGGCGGGGAAGGC GTGGAGGTGGAGCTGCTACACAACACCTCCTACACCAGGCAGGCCTGCCTGGTGTCCTGC TTCCAGCAGCTGATGGTGGAGACCTGCTCCTGTGGCTACTACCTCCACCCTCTGCCGGCG GGGGCTGAGTACTGCAGCTCTGCCCGGCACCCTGCCTGGGGACACTGCTTCTACCGCCTC TACCAGGACCTGGAGACCCACCGGCTCCCCTGTACCTCCCGCTGCCCCAGGCCCTGCAGG GAGTCTGCATTCAAGCTCTCCACTGGGACCTCCAGGTGGCCTTCCGCCAAGTCAGCTGGA TGGACTCTGGCCACGCTAGGTGAACAGGGGCTGCCGCATCAGAGCCACAGACAGAGGAGC AGCCTGGCCAAAATCAACATCGTCTACCAGGAGCTCAACTACCGCTCAGTGGAGGAGGCG CCCGTGTACTCGGTGCCGCAGCTGCTCTCGGCCATGGGCAGCCTCTGCAGCCTGTGGTTT GGGGCCTCCGTCCTCTCCCTCCTGGAGCTCCTGGAGCTGCTGCTCGATGCTTCTGCCCTC ACCCTGGTGCTAGGCGGCCGCCGGCTCCGCAGGGCGTGGTTCTCCTGGCCCAGAGCCAGC CCTGCCTCAGGGGCGTCCAGCATCAAGCCAGAGGCCAGTCAGATGCCCCCGCCTGCAGGC GGCACGTCAGATGACCCGGAGCCCAGCGGGCCTCATCTCCCACGGGTGATGCTTCCAGGG GTTCTGGCGGGAGTCTCAGCCGAAGAGAGCTGGGCTGGGCCCCAGCCCCTTGAGACTCTG GACACCTGA
- Chromosome Location
- 1
- Locus
- 1p36.3-p36.2
- External Identifiers
Resource Link UniProtKB ID P51172 UniProtKB Entry Name SCNND_HUMAN GenBank Protein ID 1066457 GenBank Gene ID U38254 GenAtlas ID SCNN1D HGNC ID HGNC:10601 - General References
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