Matrix metalloproteinase-16
Details
- Name
- Matrix metalloproteinase-16
- Synonyms
- 3.4.24.-
- Membrane-type matrix metalloproteinase 3
- Membrane-type-3 matrix metalloproteinase
- MMP-16
- MMP-X2
- MMPX2
- MT-MMP 3
- MT3-MMP
- MT3MMP
- MTMMP3
- Gene Name
- MMP16
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0003247|Matrix metalloproteinase-16 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRM SVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRY ALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKR DVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDL FLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPT RPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVF KDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQ PGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVW KGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVK EGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCK RSMQEWV
- Number of residues
- 607
- Molecular Weight
- 69521.03
- Theoretical pI
- 8.74
- GO Classification
- Functionscalcium ion binding / enzyme activator activity / metalloendopeptidase activity / zinc ion bindingProcesseschondrocyte proliferation / collagen catabolic process / craniofacial suture morphogenesis / embryonic cranial skeleton morphogenesis / endochondral ossification / extracellular matrix disassembly / extracellular matrix organization / positive regulation of catalytic activityComponentscell surface / Golgi lumen / integral component of plasma membrane / plasma membrane / proteinaceous extracellular matrix
- General Function
- Zinc ion binding
- Specific Function
- Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.
- Pfam Domain Function
- Transmembrane Regions
- 565-585
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0020554|Matrix metalloproteinase-16 (MMP16) ATGATCTTACTCACATTCAGCACTGGAAGACGGTTGGATTTCGTGCATCATTCGGGGGTG TTTTTCTTGCAAACCTTGCTTTGGATTTTATGTGCTACAGTCTGCGGAACGGAGCAGTAT TTCAATGTGGAGGTTTGGTTACAAAAGTACGGCTACCTTCCACCGACTGACCCCAGAATG TCAGTGCTGCGCTCTGCAGAGACCATGCAGTCTGCCCTAGCTGCCATGCAGCAGTTCTAT GGCATTAACATGACAGGAAAAGTGGACAGAAACACAATTGACTGGATGAAGAAGCCCCGA TGCGGTGTACCTGACCAGACAAGAGGTAGCTCCAAATTTCATATTCGTCGAAAGCGATAT GCATTGACAGGACAGAAATGGCAGCACAAGCACATCACTTACAGTATAAAGAACGTAACT CCAAAAGTAGGAGACCCTGAGACTCGTAAAGCTATTCGCCGTGCCTTTGATGTGTGGCAG AATGTAACTCCTCTGACATTTGAAGAAGTTCCCTACAGTGAATTAGAAAATGGCAAACGT GATGTGGATATAACCATTATTTTTGCATCTGGTTTCCATGGGGACAGCTCTCCCTTTGAT GGAGAGGGAGGATTTTTGGCACATGCCTACTTCCCTGGACCAGGAATTGGAGGAGATACC CATTTTGACTCAGATGAGCCATGGACACTAGGAAATCCTAATCATGATGGAAATGACTTA TTTCTTGTAGCAGTCCATGAACTGGGACATGCTCTGGGATTGGAGCATTCCAATGACCCC ACTGCCATCATGGCTCCATTTTACCAGTACATGGAAACAGACAACTTCAAACTACCTAAT GATGATTTACAGGGCATCCAGAAGATATATGGTCCACCTGACAAGATTCCTCCACCTACA AGACCTCTACCGACAGTGCCCCCACACCGCTCTATTCCTCCGGCTGACCCAAGGAAAAAT GACAGGCCAAAACCTCCTCGGCCTCCAACCGGCAGACCCTCCTATCCCGGAGCCAAACCC AACATCTGTGATGGGAACTTTAACACTCTAGCTATTCTTCGTCGTGAGATGTTTGTTTTC AAGGACCAGTGGTTTTGGCGAGTGAGAAACAACAGGGTGATGGATGGATACCCAATGCAA ATTACTTACTTCTGGCGGGGCTTGCCTCCTAGTATCGATGCAGTTTATGAAAATAGCGAC GGGAATTTTGTGTTCTTTAAAGGTAACAAATATTGGGTGTTCAAGGATACAACTCTTCAA CCTGGTTACCCTCATGACTTGATAACCCTTGGAAGTGGAATTCCCCCTCATGGTATTGAT TCAGCCATTTGGTGGGAGGACGTCGGGAAAACCTATTTCTTCAAGGGAGACAGATATTGG AGATATAGTGAAGAAATGAAAACAATGGACCCTGGCTATCCCAAGCCAATCACAGTCTGG AAAGGGATCCCTGAATCTCCTCAGGGAGCATTTGTACACAAAGAAAATGGCTTTACGTAT TTCTACAAAGGAAAGGAGTATTGGAAATTCAACAACCAGATACTCAAGGTAGAACCTGGA TATCCAAGATCCATCCTCAAGGATTTTATGGGCTGTGATGGACCAACAGACAGAGTTAAA GAAGGACACAGCCCACCAGATGATGTAGACATTGTCATCAAACTGGACAACACAGCCAGC ACTGTGAAAGCCATAGCTATTGTCATTCCCTGCATCTTGGCCTTATGCCTCCTTGTATTG GTTTACACTGTGTTCCAGTTCAAGAGGAAAGGAACACCCCGCCACATACTGTACTGTAAA CGCTCTATGCAAGAGTGGGTGTGA
- Chromosome Location
- 8
- Locus
- 8q21
- External Identifiers
Resource Link UniProtKB ID P51512 UniProtKB Entry Name MMP16_HUMAN GenBank Protein ID 2662306 GenBank Gene ID AB009303 GenAtlas ID MMP16 HGNC ID HGNC:7162 - General References
- Takino T, Sato H, Shinagawa A, Seiki M: Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library. MT-MMPs form a unique membrane-type subclass in the MMP family. J Biol Chem. 1995 Sep 29;270(39):23013-20. [Article]
- Matsumoto S, Katoh M, Saito S, Watanabe T, Masuho Y: Identification of soluble type of membrane-type matrix metalloproteinase-3 formed by alternatively spliced mRNA. Biochim Biophys Acta. 1997 Nov 1;1354(2):159-70. [Article]
- Shofuda K, Yasumitsu H, Nishihashi A, Miki K, Miyazaki K: Expression of three membrane-type matrix metalloproteinases (MT-MMPs) in rat vascular smooth muscle cells and characterization of MT3-MMPs with and without transmembrane domain. J Biol Chem. 1997 Apr 11;272(15):9749-54. [Article]
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- Iida J, Pei D, Kang T, Simpson MA, Herlyn M, Furcht LT, McCarthy JB: Melanoma chondroitin sulfate proteoglycan regulates matrix metalloproteinase-dependent human melanoma invasion into type I collagen. J Biol Chem. 2001 Jun 1;276(22):18786-94. Epub 2001 Mar 6. [Article]
- Lang R, Braun M, Sounni NE, Noel A, Frankenne F, Foidart JM, Bode W, Maskos K: Crystal structure of the catalytic domain of MMP-16/MT3-MMP: characterization of MT-MMP specific features. J Mol Biol. 2004 Feb 6;336(1):213-25. [Article]