DNA polymerase I

Details

Name
DNA polymerase I
Synonyms
  • 2.7.7.7
  • pol
  • POL I
Gene Name
polA
Organism
Geobacillus stearothermophilus
Amino acid sequence
>lcl|BSEQ0007417|DNA polymerase I
MKNKLVLIDGNSVAYRAFFALPLLHNDKGIHTNAVYGFTMMLNKILAEEQPTHILVAFDA
GKTTFRHETFQDYKGGRQQTPPELSEQFPLLRELLKAYRIPAYELDHYEADDIIGTMAAR
AEREGFAVKVISGDRDLTQLASPQVTVEITKKGITDIESYTPETVVEKYGLTPEQIVDLK
GLMGDKSDNIPGVPGIGEKTAVKLLKQFGTVENVLASIDEIKGEKLKENLRQYRDLALLS
KQLAAICRDAPVELTLDDIVYKGEDREKVVALFQELGFQSFLDKMAVQTDEGEKPLAGMD
FAIADSVTDEMLADKAALVVEVVGDNYHHAPIVGIALANERGRFFLRPETALADPKFLAW
LGDETKKKTMFDSKRAAVALKWKGIELRGVVFDLLLAAYLLDPAQAAGDVAAVAKMHQYE
AVRSDEAVYGKGAKRTVPDEPTLAEHLVRKAAAIWALEEPLMDELRRNEQDRLLTELEQP
LAGILANMEFTGVKVDTKRLEQMGAELTEQLQAVERRIYELAGQEFNINSPKQLGTVLFD
KLQLPVLKKTKTGYSTSADVLEKLAPHHEIVEHILHYRQLGKLQSTYIEGLLKVVHPVTG
KVHTMFNQALTQTGRLSSVEPNLQNIPIRLEEGRKIRQAFVPSEPDWLIFAADYSQIELR
VLAHIAEDDNLIEAFRRGLDIHTKTAMDIFHVSEEDVTANMRRQAKAVNFGIVYGISDYG
LAQNLNITRKEAAEFIERYFASFPGVKQYMDNIVQEAKQKGYVTTLLHRRRYLPDITSRN
FNVRSFAERTAMNTPIQGSAADIIKKAMIDLSVRLREERLQARLLLQVHDELILEAPKEE
IERLCRLVPEVMEQAVTLRVPLKVDYHYGPTWYDAK
Number of residues
876
Molecular Weight
98669.425
Theoretical pI
5.77
GO Classification
Functions
3'-5' exonuclease activity / DNA binding / DNA-directed DNA polymerase activity
Processes
DNA repair / DNA-dependent DNA replication
General Function
Dna-directed dna polymerase activity
Specific Function
In addition to polymerase activity, this DNA polymerase exhibits 5' to 3' exonuclease activity.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0007416|2865 bp
GTGGCGTCGACAAGGCGCGCAGCCGCAACTCAGGCGGGACGGGCTGGGCCCTTCGATCGT
CAAGCACTTGGTCGAGGCGCATCGCGGCTACATTACGGTGACGAGCGAAGTCGGGCGCGG
CACCGAGTTTACGATTCATTTCCCGAAGCCGGAGCGGTAGCCGGCTTCTTTTTATGGCCC
CCGCCGGCGTGGTACAATAGAACAAGGAACGTCCGAGGAGGGATGATGTTGAAAAACAAG
CTCGTCTTAATTGACGGCAACAGCGTGGCGTACCGCGCCTTTTTTGCGTTGCCGCTTTTG
CATAACGATAAAGGGATTCATACGAACGCAGTCTACGGGTTTACGATGATGTTAAACAAA
ATTTTGGCGGAAGAGCAGCCGACCCACATTCTCGTTGCGTTTGACGCCGGGAAAACGACG
TTCCGCCATGAAACGTTCCAAGACTATAAAGGCGGGCGGCAGCAGACGCCGCCGGAACTG
TCGGAACAGTTTCCGCTCGTGCGCGAATTGCTCAAAGCGTACCGCATCCCCGCCTATGAG
CTCGACCATTATGAAGCGGATGACATCATCGGAACGATGGCGGCGCGGGCTGAGCGAGAA
GGGTTTGCAGTGAAAGTCATTTCCGGCGACCGCGATTTAACCCAGCTTGCTTCCCCGCAA
GTGACGGTGGAGATTACGAAAAAAGGGATTACCGACATCGAGTCGTACACGCCGGAGACG
GTCGTGGAAAAATACGGCCTCACCCCGGAGCAAATTGTCGACTTGAAAGGATTGATGGGC
GACAAATCCGACAACATCCCTGGCGTGCCCGGCATCGGGAAAAAAACAGCCGTCAAGCTG
CTCAAGCAATTCGGCACGGTCGAAAACGTACTGGCATCGATCGATGAGATCAAAGGGGAG
AAGCTGAAAGAAAATTTGCGCCAATACCGGGATTTGGCGCTTTTAAGCAAACAGCTGGCC
GCTATTTGCCGCGACGCCCCGGTTGAGCTGACGCTCGATGACATTGTCTACAAAGGAGAA
GACCGGGAAAAAGTGGTCGCCTTGTTTCAGGAGCTCGGATTCCAGTCGTTTCTCGACAAG
ATGGCCGTCCAAACGGATGAAGGCGAAAAGCCGCTCGCCGGGATGGATTTTGCGATCGCC
GACAGCGTCACGGACGAAATGCTCGCCGACAAAGCGGCCCTCGTCGTGGAGGTGGTGGGC
GACAACTATCACCATGCCCCGATTGTCGGGATCGCCTTGGCCAACGAACGCGGGCGGTTT
TTCCTGCGCCCGGAGACGGCCGTCGCCGATCCGAAATTTCTCGCTTGGCTTGGCGATGAG
ACGAAGAAAAAAACGATGTTTGATTCAAAGCGGGCGGCCGTCGCGCTAAATGGGAAAGGA
ATCGAACTGGCTGGCGTCGGCGTCGTGTTCGATCTGTTGCTGGCCGCTTACTTGCTCGAT
CCGGCGCAGGCGGCGGGCGACGTTGCCGCGGTGGCGAAAATGCATCAGTACGAGGCGGTG
CGATCGGATGAGGCGGTCTATGGAAAAGGAGCGAAGCGGACGGTTCCTGATGAACCGACG
CTTGCCGAGCAGCTCGTCCGCAAGGCGGCGGCCATTTGGGCGCTTGAAGAGCCGTTGATG
GACGAACTGCGCCGCAACGAACAAGATCGGCTGCTGACCGAGCTCGAACACGCGCTGGCT
GGCATTTTGGCCAATATGGAATTTACTGGAGTGAAAGTGGACACGAAGCGGCTTGAACAG
ATGGGGGCGGAGCTCACCGAGCAGCTGCAGGCGGTCGAGCGGCGCATTTACGAACTCGCC
GGCCAAGAGTTCAACATTAACTCGCCGAAACAGCTCGGGACGGTTTTATTTGACAAGCTG
CAGCTCCCGGTGTTGAAAAAGACAAAAACCGGCTATTCGACTTCAGCCGATGTGCTAGAA
AAGCTTGCACCGCACCATGAAATCGTCGAACATATTTTGCATTACCGCCAACTCGGCAAG
CTGCAGTCAACGTATATTGAAGGGCTGCTGAAAGTGGTGCACCCCGTGACGGGCAAAGTG
CACACGATGTTCAATCAGGCGTTGACGCAAACCGGGCGCCTCAGCTCCGTCGAACCGAAT
TTGCAAAACATTCCGATTCGGCTTGAGGAAGGGCGGAAAATCCGCCAGGCGTTCGTGCCG
TCGGAGCCGGACTGGCTCATCTTTGCGGCCGACTATTCGCAAATCGAGCTGCGCGTCCTC
GCCCATATCGCGGAAGATGACAATTTGATTGAAGCGTTCCGGCGCTGGTTGGACATCCAT
ACGAAAACAGCCATGGACATTTTCCATGTGAGCGAAGAAGACGTGACAGCCAACATGCGC
CGCCAAGCGAAGGCCGTCAATTTTGGCATCGTGTACGGCATTAGTGATTACGGTCTGGCG
CAAAACTTGAACATTACGCGCAAAGAAGCGGCTGAATTTATTGAGCGATATTTTGCCAGT
TTTCCAGGTGTAAAGCAATATATGGACAACATTGTGCAAGAAGCGAAACAAAAAGGGTAT
GTGACGACGCTGCTGCATCGGCGCCGCTATTTGCCCGATATTACAAGCCGCAACTTCAAC
GTCCGCACGTTCGCCGAGCGGACGGCGATGAACACACCGATCCAGGGATCCGCTGCCGAC
ATCATTAAGAAAGCGATGATCGATCTAAGCGTGAGCGTGCGCGAAGAACGGCTGCAGGCG
CGCCTGTTGCTGCAAGGTCATGACGAACTCATTTTGGAGGCGCCGAAAGAGGAAATCGGA
CGGCTGTGCCGCCTCGTTCCGGAAGTGATGGAGCAAGCCGTGACACTTCGCGTGCCGCTG
AAAGTCGATTACCATTACGGTCCGACGTGGTACGACGCCAAATAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP52026
UniProtKB Entry NameDPO1_GEOSE
GenBank Protein ID755588
GenBank Gene IDU23149
General References
  1. Phang SM, Teo CY, Lo E, Wong VW: Cloning and complete sequence of the DNA polymerase-encoding gene (BstpolI) and characterisation of the Klenow-like fragment from Bacillus stearothermophilus. Gene. 1995 Sep 22;163(1):65-8. [Article]
  2. Riggs MG, Tudor S, Sivaram M, McDonough SH: Construction of single amino acid substitution mutants of cloned Bacillus stearothermophilus DNA polymerase I which lack 5'-->3' exonuclease activity. Biochim Biophys Acta. 1996 Jun 7;1307(2):178-86. [Article]
  3. Kiefer JR, Mao C, Hansen CJ, Basehore SL, Hogrefe HH, Braman JC, Beese LS: Crystal structure of a thermostable Bacillus DNA polymerase I large fragment at 2.1 A resolution. Structure. 1997 Jan 15;5(1):95-108. [Article]
  4. Kiefer JR, Mao C, Braman JC, Beese LS: Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal. Nature. 1998 Jan 15;391(6664):304-7. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB074351,2,3-TRIHYDROXY-1,2,3,4-TETRAHYDROBENZO[A]PYRENEexperimentalunknownDetails