DNA polymerase I
Details
- Name
- DNA polymerase I
- Synonyms
- 2.7.7.7
- pol
- POL I
- Gene Name
- polA
- Organism
- Geobacillus stearothermophilus
- Amino acid sequence
>lcl|BSEQ0007417|DNA polymerase I MKNKLVLIDGNSVAYRAFFALPLLHNDKGIHTNAVYGFTMMLNKILAEEQPTHILVAFDA GKTTFRHETFQDYKGGRQQTPPELSEQFPLLRELLKAYRIPAYELDHYEADDIIGTMAAR AEREGFAVKVISGDRDLTQLASPQVTVEITKKGITDIESYTPETVVEKYGLTPEQIVDLK GLMGDKSDNIPGVPGIGEKTAVKLLKQFGTVENVLASIDEIKGEKLKENLRQYRDLALLS KQLAAICRDAPVELTLDDIVYKGEDREKVVALFQELGFQSFLDKMAVQTDEGEKPLAGMD FAIADSVTDEMLADKAALVVEVVGDNYHHAPIVGIALANERGRFFLRPETALADPKFLAW LGDETKKKTMFDSKRAAVALKWKGIELRGVVFDLLLAAYLLDPAQAAGDVAAVAKMHQYE AVRSDEAVYGKGAKRTVPDEPTLAEHLVRKAAAIWALEEPLMDELRRNEQDRLLTELEQP LAGILANMEFTGVKVDTKRLEQMGAELTEQLQAVERRIYELAGQEFNINSPKQLGTVLFD KLQLPVLKKTKTGYSTSADVLEKLAPHHEIVEHILHYRQLGKLQSTYIEGLLKVVHPVTG KVHTMFNQALTQTGRLSSVEPNLQNIPIRLEEGRKIRQAFVPSEPDWLIFAADYSQIELR VLAHIAEDDNLIEAFRRGLDIHTKTAMDIFHVSEEDVTANMRRQAKAVNFGIVYGISDYG LAQNLNITRKEAAEFIERYFASFPGVKQYMDNIVQEAKQKGYVTTLLHRRRYLPDITSRN FNVRSFAERTAMNTPIQGSAADIIKKAMIDLSVRLREERLQARLLLQVHDELILEAPKEE IERLCRLVPEVMEQAVTLRVPLKVDYHYGPTWYDAK
- Number of residues
- 876
- Molecular Weight
- 98669.425
- Theoretical pI
- 5.77
- GO Classification
- Functions3'-5' exonuclease activity / DNA binding / DNA-directed DNA polymerase activityProcessesDNA repair / DNA-dependent DNA replication
- General Function
- Dna-directed dna polymerase activity
- Specific Function
- In addition to polymerase activity, this DNA polymerase exhibits 5' to 3' exonuclease activity.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0007416|2865 bp GTGGCGTCGACAAGGCGCGCAGCCGCAACTCAGGCGGGACGGGCTGGGCCCTTCGATCGT CAAGCACTTGGTCGAGGCGCATCGCGGCTACATTACGGTGACGAGCGAAGTCGGGCGCGG CACCGAGTTTACGATTCATTTCCCGAAGCCGGAGCGGTAGCCGGCTTCTTTTTATGGCCC CCGCCGGCGTGGTACAATAGAACAAGGAACGTCCGAGGAGGGATGATGTTGAAAAACAAG CTCGTCTTAATTGACGGCAACAGCGTGGCGTACCGCGCCTTTTTTGCGTTGCCGCTTTTG CATAACGATAAAGGGATTCATACGAACGCAGTCTACGGGTTTACGATGATGTTAAACAAA ATTTTGGCGGAAGAGCAGCCGACCCACATTCTCGTTGCGTTTGACGCCGGGAAAACGACG TTCCGCCATGAAACGTTCCAAGACTATAAAGGCGGGCGGCAGCAGACGCCGCCGGAACTG TCGGAACAGTTTCCGCTCGTGCGCGAATTGCTCAAAGCGTACCGCATCCCCGCCTATGAG CTCGACCATTATGAAGCGGATGACATCATCGGAACGATGGCGGCGCGGGCTGAGCGAGAA GGGTTTGCAGTGAAAGTCATTTCCGGCGACCGCGATTTAACCCAGCTTGCTTCCCCGCAA GTGACGGTGGAGATTACGAAAAAAGGGATTACCGACATCGAGTCGTACACGCCGGAGACG GTCGTGGAAAAATACGGCCTCACCCCGGAGCAAATTGTCGACTTGAAAGGATTGATGGGC GACAAATCCGACAACATCCCTGGCGTGCCCGGCATCGGGAAAAAAACAGCCGTCAAGCTG CTCAAGCAATTCGGCACGGTCGAAAACGTACTGGCATCGATCGATGAGATCAAAGGGGAG AAGCTGAAAGAAAATTTGCGCCAATACCGGGATTTGGCGCTTTTAAGCAAACAGCTGGCC GCTATTTGCCGCGACGCCCCGGTTGAGCTGACGCTCGATGACATTGTCTACAAAGGAGAA GACCGGGAAAAAGTGGTCGCCTTGTTTCAGGAGCTCGGATTCCAGTCGTTTCTCGACAAG ATGGCCGTCCAAACGGATGAAGGCGAAAAGCCGCTCGCCGGGATGGATTTTGCGATCGCC GACAGCGTCACGGACGAAATGCTCGCCGACAAAGCGGCCCTCGTCGTGGAGGTGGTGGGC GACAACTATCACCATGCCCCGATTGTCGGGATCGCCTTGGCCAACGAACGCGGGCGGTTT TTCCTGCGCCCGGAGACGGCCGTCGCCGATCCGAAATTTCTCGCTTGGCTTGGCGATGAG ACGAAGAAAAAAACGATGTTTGATTCAAAGCGGGCGGCCGTCGCGCTAAATGGGAAAGGA ATCGAACTGGCTGGCGTCGGCGTCGTGTTCGATCTGTTGCTGGCCGCTTACTTGCTCGAT CCGGCGCAGGCGGCGGGCGACGTTGCCGCGGTGGCGAAAATGCATCAGTACGAGGCGGTG CGATCGGATGAGGCGGTCTATGGAAAAGGAGCGAAGCGGACGGTTCCTGATGAACCGACG CTTGCCGAGCAGCTCGTCCGCAAGGCGGCGGCCATTTGGGCGCTTGAAGAGCCGTTGATG GACGAACTGCGCCGCAACGAACAAGATCGGCTGCTGACCGAGCTCGAACACGCGCTGGCT GGCATTTTGGCCAATATGGAATTTACTGGAGTGAAAGTGGACACGAAGCGGCTTGAACAG ATGGGGGCGGAGCTCACCGAGCAGCTGCAGGCGGTCGAGCGGCGCATTTACGAACTCGCC GGCCAAGAGTTCAACATTAACTCGCCGAAACAGCTCGGGACGGTTTTATTTGACAAGCTG CAGCTCCCGGTGTTGAAAAAGACAAAAACCGGCTATTCGACTTCAGCCGATGTGCTAGAA AAGCTTGCACCGCACCATGAAATCGTCGAACATATTTTGCATTACCGCCAACTCGGCAAG CTGCAGTCAACGTATATTGAAGGGCTGCTGAAAGTGGTGCACCCCGTGACGGGCAAAGTG CACACGATGTTCAATCAGGCGTTGACGCAAACCGGGCGCCTCAGCTCCGTCGAACCGAAT TTGCAAAACATTCCGATTCGGCTTGAGGAAGGGCGGAAAATCCGCCAGGCGTTCGTGCCG TCGGAGCCGGACTGGCTCATCTTTGCGGCCGACTATTCGCAAATCGAGCTGCGCGTCCTC GCCCATATCGCGGAAGATGACAATTTGATTGAAGCGTTCCGGCGCTGGTTGGACATCCAT ACGAAAACAGCCATGGACATTTTCCATGTGAGCGAAGAAGACGTGACAGCCAACATGCGC CGCCAAGCGAAGGCCGTCAATTTTGGCATCGTGTACGGCATTAGTGATTACGGTCTGGCG CAAAACTTGAACATTACGCGCAAAGAAGCGGCTGAATTTATTGAGCGATATTTTGCCAGT TTTCCAGGTGTAAAGCAATATATGGACAACATTGTGCAAGAAGCGAAACAAAAAGGGTAT GTGACGACGCTGCTGCATCGGCGCCGCTATTTGCCCGATATTACAAGCCGCAACTTCAAC GTCCGCACGTTCGCCGAGCGGACGGCGATGAACACACCGATCCAGGGATCCGCTGCCGAC ATCATTAAGAAAGCGATGATCGATCTAAGCGTGAGCGTGCGCGAAGAACGGCTGCAGGCG CGCCTGTTGCTGCAAGGTCATGACGAACTCATTTTGGAGGCGCCGAAAGAGGAAATCGGA CGGCTGTGCCGCCTCGTTCCGGAAGTGATGGAGCAAGCCGTGACACTTCGCGTGCCGCTG AAAGTCGATTACCATTACGGTCCGACGTGGTACGACGCCAAATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P52026 UniProtKB Entry Name DPO1_GEOSE GenBank Protein ID 755588 GenBank Gene ID U23149 - General References
- Phang SM, Teo CY, Lo E, Wong VW: Cloning and complete sequence of the DNA polymerase-encoding gene (BstpolI) and characterisation of the Klenow-like fragment from Bacillus stearothermophilus. Gene. 1995 Sep 22;163(1):65-8. [Article]
- Riggs MG, Tudor S, Sivaram M, McDonough SH: Construction of single amino acid substitution mutants of cloned Bacillus stearothermophilus DNA polymerase I which lack 5'-->3' exonuclease activity. Biochim Biophys Acta. 1996 Jun 7;1307(2):178-86. [Article]
- Kiefer JR, Mao C, Hansen CJ, Basehore SL, Hogrefe HH, Braman JC, Beese LS: Crystal structure of a thermostable Bacillus DNA polymerase I large fragment at 2.1 A resolution. Structure. 1997 Jan 15;5(1):95-108. [Article]
- Kiefer JR, Mao C, Braman JC, Beese LS: Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal. Nature. 1998 Jan 15;391(6664):304-7. [Article]