DNA polymerase epsilon subunit 2
Details
- Name
- DNA polymerase epsilon subunit 2
- Synonyms
- 2.7.7.7
- DNA polymerase epsilon subunit B
- DNA polymerase II subunit 2
- DPE2
- Gene Name
- POLE2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0006955|DNA polymerase epsilon subunit 2 MAPERLRSRALSAFKLRGLLLRGEAIKYLTEALQSISELELEDKLEKIINAVEKQPLSSN MIERSVVEAAVQECSQSVDETIEHVFNIIGAFDIPRFVYNSERKKFLPLLMTNHPAPNLF GTPRDKAEMFRERYTILHQRTHRHELFTPPVIGSHPDESGSKFQLKTIETLLGSTTKIGD AIVLGMITQLKEGKFFLEDPTGTVQLDLSKAQFHSGLYTEACFVLAEGWFEDQVFHVNAF GFPPTEPSSTTRAYYGNINFFGGPSNTSVKTSAKLKQLEEENKDAMFVFLSDVWLDQVEV LEKLRIMFAGYSPAPPTCFILCGNFSSAPYGKNQVQALKDSLKTLADIICEYPDIHQSSR FVFVPGPEDPGFGSILPRPPLAESITNEFRQRVPFSVFTTNPCRIQYCTQEITVFREDLV NKMCRNCVRFPSSNLAIPNHFVKTILSQGHLTPLPLYVCPVYWAYDYALRVYPVPDLLVI ADKYDPFTTTNTECLCINPGSFPRSGFSFKVFYPSNKTVEDSKLQGF
- Number of residues
- 527
- Molecular Weight
- 59536.64
- Theoretical pI
- 6.3
- GO Classification
- FunctionsDNA binding / DNA-directed DNA polymerase activityProcessesDNA repair / DNA replication / DNA replication initiation / DNA-dependent DNA replication / error-prone translesion synthesis / G1/S transition of mitotic cell cycle / mitotic cell cycle / telomere maintenance / telomere maintenance via recombination / telomere maintenance via semi-conservative replicationComponentsepsilon DNA polymerase complex / intracellular membrane-bounded organelle / nucleoplasm
- General Function
- Dna-directed dna polymerase activity
- Specific Function
- Participates in DNA repair and in chromosomal DNA replication.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0012513|DNA polymerase epsilon subunit 2 (POLE2) ATGGCGCCGGAGCGGCTGCGGAGCCGGGCGCTCTCCGCCTTCAAGTTGCGGGGCTTGCTG CTCCGTGGTGAAGCTATTAAGTACCTCACAGAAGCTCTTCAGTCTATCAGTGAATTAGAG CTTGAAGATAAACTGGAAAAGATAATTAATGCAGTTGAGAAGCAACCCTTGTCATCAAAC ATGATTGAACGATCTGTGGTGGAAGCAGCAGTCCAGGAATGCAGTCAGTCTGTTGATGAA ACTATTCTGTTAATGACCAACCACCCTGCACCAAATTTATTTGGAACACCAAGAGATAAA GCAGAGATGTTTCGTGAGCGATATACCATTTTGCACCAGAGGACCCACAGGCATGAATTA TTTACTCCTCCGGTGATAGGTTCTCACCCTGATGAAAGCGGAAGCAAATTCCAGCTTAAA ACAATAGAAACCTTATTGGGTAGTACAACCAAAATCGGAGATGCGATTGTTCTTGGAATG ATAACGCAGTTAAAAGAGGGAAAATTTTTTCTGGAAGATCCTACTGGAACAGTCCAACTA GACCTTAGTAAAGCTCAGTTCCATAGTGGTTTATACACAGAGGCATGCTTTGTCTTAGCA GAAGGTTGGTTTGAAGATCAAGTGTTTCATGTCAATGCCTTTGGATTTCCACCCACTGAG CCCTCTAGTACTACTAGGGCATACTATGGAAATATTAATTTTTTTGGAGGTCCTTCTAAT ACATCTGTGAAGACTTCTGCAAAACTAAAACAGCTAGAAGAGGAGAATAAAGATGCTATG TTTGTGTTTTTATCTGATGTTTGGTTGGACCAGGTGGAAGTATTGGAAAAACTTCGCATA ATGTTTGCTGGTTATTCACCAGCACCTCCAACCTGCTTTATTCTGTGTGGTAATTTTTCA TCTGCACCATATGGAAAAAATCAAGTTCAAGCTTTGAAAGATTCCCTAAAAACTTTGGCA GATATAATATGTGAATACCCAGATATTCACCAAAGTAGTCGTTTTGTGTTTGTACCTGGT CCAGAGGATCCTGGATTTGGTTCCATCTTACCAAGGCCACCACTTGCTGAAAGCATCACT AATGAATTCAGACAAAGGGTACCATTTTCAGTTTTTACTACTAATCCTTGCAGAATTCAG TACTGTACACAGGAAATTACTGTCTTCCGTGAAGACTTAGTAAATAAAATGTGCAGAAAC TGCGTCCGTTTTCCTAGCAGCAATTTGGCTATTCCTAATCACTTTGTAAAGACTATCTTA TCCCAAGGACATCTGACTCCCCTACCTCTTTATGTCTGCCCAGTGTATTGGGCATATGAC TATGCTTTGAGAGTGTATCCTGTGCCCGATCTACTTGTCATTGCAGACAAATATGATCCT TTCACTACGACAAATACCGAATGCCTCTGCATAAACCCTGGCTCTTTTCCAAGAAGTGGA TTTTCATTCAAAGTTTTTTATCCTTCTAATAAGACAGTAGAAGATAGCAAACTTCAAGGC TTTTGA
- Chromosome Location
- 14
- Locus
- 14q21-q22
- External Identifiers
Resource Link UniProtKB ID P56282 UniProtKB Entry Name DPOE2_HUMAN GenBank Protein ID 2697123 GenBank Gene ID AF025840 HGNC ID HGNC:9178 - General References
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