50S ribosomal protein L4

Details

Name
50S ribosomal protein L4
Synonyms
Not Available
Gene Name
rplD
Organism
Escherichia coli O157:H7
Amino acid sequence
>lcl|BSEQ0011764|50S ribosomal protein L4
MELVLKDAQSALTVSETTFGRDFNEALVHQVVVAYAAGARQGTRAQKTRAEVTGSGKKPW
RQKGTGRARSGSIKSPIWRSGGVTFAARPQDHSQKVNKKMYRGALKSILSELVRQDRLIV
VEKFSVEAPKTKLLAQKLKDMALEDVLIITGELDENLFLAARNLHKVDVRDATGIDPVSL
IAFDKVVMTADAVKQVEEMLA
Number of residues
201
Molecular Weight
22086.36
Theoretical pI
10.45
GO Classification
Functions
rRNA binding / structural constituent of ribosome
Processes
DNA-templated transcription, termination / regulation of transcription, DNA-templated / regulation of translation / translation
Components
ribosome
General Function
Structural constituent of ribosome
Specific Function
One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.Protein L4 is a both a transcriptional repressor and a translational repressor protein. It regulates transcription of the S10 operon (to which L4 belongs) by causing premature termination of transcription within the S10 leader. L4 controls the translation of the S10 operon by binding to its mRNA (By similarity).Forms part of the polypeptide exit tunnel.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0011765|50S ribosomal protein L4 (rplD)
ATGGAATTAGTATTGAAAGACGCGCAGAGCGCGCTGACTGTTTCCGAAACTACCTTCGGT
CGTGATTTCAACGAAGCGCTGGTTCACCAGGTTGTTGTTGCTTATGCAGCTGGTGCTCGT
CAGGGTACTCGTGCTCAGAAGACTCGTGCTGAAGTAACTGGTTCCGGTAAAAAACCGTGG
CGCCAGAAAGGCACCGGCCGTGCGCGTTCTGGTTCTATCAAGAGCCCGATCTGGCGTTCT
GGTGGCGTGACCTTTGCTGCTCGTCCGCAGGACCACAGTCAAAAAGTTAACAAGAAGATG
TACCGCGGCGCGCTGAAAAGCATCCTGTCCGAACTGGTACGTCAGGATCGTCTGATCGTT
GTCGAGAAGTTCTCTGTAGAAGCGCCGAAAACTAAGCTGCTGGCACAGAAACTGAAAGAC
ATGGCTCTGGAAGATGTGCTGATCATCACCGGTGAGCTGGACGAAAACCTGTTCCTGGCT
GCGCGCAACCTGCACAAGGTTGACGTACGCGATGCAACTGGTATCGACCCGGTTAGCCTG
ATCGCCTTCGACAAAGTCGTAATGACTGCTGATGCTGTTAAGCAAGTTGAGGAGATGCTG
GCATGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP60725
UniProtKB Entry NameRL4_ECO57
GenBank Gene IDAE005174
General References
  1. Perna NT, Plunkett G 3rd, Burland V, Mau B, Glasner JD, Rose DJ, Mayhew GF, Evans PS, Gregor J, Kirkpatrick HA, Posfai G, Hackett J, Klink S, Boutin A, Shao Y, Miller L, Grotbeck EJ, Davis NW, Lim A, Dimalanta ET, Potamousis KD, Apodaca J, Anantharaman TS, Lin J, Yen G, Schwartz DC, Welch RA, Blattner FR: Genome sequence of enterohaemorrhagic Escherichia coli O157:H7. Nature. 2001 Jan 25;409(6819):529-33. [Article]
  2. Hayashi T, Makino K, Ohnishi M, Kurokawa K, Ishii K, Yokoyama K, Han CG, Ohtsubo E, Nakayama K, Murata T, Tanaka M, Tobe T, Iida T, Takami H, Honda T, Sasakawa C, Ogasawara N, Yasunaga T, Kuhara S, Shiba T, Hattori M, Shinagawa H: Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12. DNA Res. 2001 Feb 28;8(1):11-22. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails