50S ribosomal protein L4
Details
- Name
- 50S ribosomal protein L4
- Synonyms
- Not Available
- Gene Name
- rplD
- Organism
- Escherichia coli O157:H7
- Amino acid sequence
>lcl|BSEQ0011764|50S ribosomal protein L4 MELVLKDAQSALTVSETTFGRDFNEALVHQVVVAYAAGARQGTRAQKTRAEVTGSGKKPW RQKGTGRARSGSIKSPIWRSGGVTFAARPQDHSQKVNKKMYRGALKSILSELVRQDRLIV VEKFSVEAPKTKLLAQKLKDMALEDVLIITGELDENLFLAARNLHKVDVRDATGIDPVSL IAFDKVVMTADAVKQVEEMLA
- Number of residues
- 201
- Molecular Weight
- 22086.36
- Theoretical pI
- 10.45
- GO Classification
- FunctionsrRNA binding / structural constituent of ribosomeProcessesDNA-templated transcription, termination / regulation of transcription, DNA-templated / regulation of translation / translationComponentsribosome
- General Function
- Structural constituent of ribosome
- Specific Function
- One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.Protein L4 is a both a transcriptional repressor and a translational repressor protein. It regulates transcription of the S10 operon (to which L4 belongs) by causing premature termination of transcription within the S10 leader. L4 controls the translation of the S10 operon by binding to its mRNA (By similarity).Forms part of the polypeptide exit tunnel.
- Pfam Domain Function
- Ribosomal_L4 (PF00573)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0011765|50S ribosomal protein L4 (rplD) ATGGAATTAGTATTGAAAGACGCGCAGAGCGCGCTGACTGTTTCCGAAACTACCTTCGGT CGTGATTTCAACGAAGCGCTGGTTCACCAGGTTGTTGTTGCTTATGCAGCTGGTGCTCGT CAGGGTACTCGTGCTCAGAAGACTCGTGCTGAAGTAACTGGTTCCGGTAAAAAACCGTGG CGCCAGAAAGGCACCGGCCGTGCGCGTTCTGGTTCTATCAAGAGCCCGATCTGGCGTTCT GGTGGCGTGACCTTTGCTGCTCGTCCGCAGGACCACAGTCAAAAAGTTAACAAGAAGATG TACCGCGGCGCGCTGAAAAGCATCCTGTCCGAACTGGTACGTCAGGATCGTCTGATCGTT GTCGAGAAGTTCTCTGTAGAAGCGCCGAAAACTAAGCTGCTGGCACAGAAACTGAAAGAC ATGGCTCTGGAAGATGTGCTGATCATCACCGGTGAGCTGGACGAAAACCTGTTCCTGGCT GCGCGCAACCTGCACAAGGTTGACGTACGCGATGCAACTGGTATCGACCCGGTTAGCCTG ATCGCCTTCGACAAAGTCGTAATGACTGCTGATGCTGTTAAGCAAGTTGAGGAGATGCTG GCATGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P60725 UniProtKB Entry Name RL4_ECO57 GenBank Gene ID AE005174 - General References
- Perna NT, Plunkett G 3rd, Burland V, Mau B, Glasner JD, Rose DJ, Mayhew GF, Evans PS, Gregor J, Kirkpatrick HA, Posfai G, Hackett J, Klink S, Boutin A, Shao Y, Miller L, Grotbeck EJ, Davis NW, Lim A, Dimalanta ET, Potamousis KD, Apodaca J, Anantharaman TS, Lin J, Yen G, Schwartz DC, Welch RA, Blattner FR: Genome sequence of enterohaemorrhagic Escherichia coli O157:H7. Nature. 2001 Jan 25;409(6819):529-33. [Article]
- Hayashi T, Makino K, Ohnishi M, Kurokawa K, Ishii K, Yokoyama K, Han CG, Ohtsubo E, Nakayama K, Murata T, Tanaka M, Tobe T, Iida T, Takami H, Honda T, Sasakawa C, Ogasawara N, Yasunaga T, Kuhara S, Shiba T, Hattori M, Shinagawa H: Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12. DNA Res. 2001 Feb 28;8(1):11-22. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details