Proteasome subunit alpha type-6
Details
- Name
- Proteasome subunit alpha type-6
- Synonyms
- 27 kDa prosomal protein
- 3.4.25.1
- Macropain iota chain
- Multicatalytic endopeptidase complex iota chain
- p27K
- PROS-27
- PROS27
- Proteasome iota chain
- Gene Name
- PSMA6
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0007495|Proteasome subunit alpha type-6 MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKL LDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIAD ISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLE KKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLV ALAERD
- Number of residues
- 246
- Molecular Weight
- 27399.235
- Theoretical pI
- 6.74
- GO Classification
- Functionsendopeptidase activity / NF-kappaB binding / purine ribonucleoside triphosphate binding / RNA binding / threonine-type endopeptidase activityProcessesactivation of MAPKK activity / anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process / antigen processing and presentation of exogenous peptide antigen via MHC class I / antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent / antigen processing and presentation of peptide antigen via MHC class I / apoptotic process / axon guidance / cellular nitrogen compound metabolic process / DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest / epidermal growth factor receptor signaling pathway / Fc-epsilon receptor signaling pathway / fibroblast growth factor receptor signaling pathway / G1/S transition of mitotic cell cycle / gene expression / innate immune response / insulin receptor signaling pathway / MAPK cascade / mitotic cell cycle / negative regulation of apoptotic process / negative regulation of canonical Wnt signaling pathway / negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle / neurotrophin TRK receptor signaling pathway / NIK/NF-kappaB signaling / polyamine metabolic process / positive regulation of canonical Wnt signaling pathway / positive regulation of NF-kappaB transcription factor activity / positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition / programmed cell death / proteasomal ubiquitin-independent protein catabolic process / proteasome-mediated ubiquitin-dependent protein catabolic process / protein polyubiquitination / proteolysis involved in cellular protein catabolic process / Ras protein signal transduction / regulation of apoptotic process / regulation of cellular amino acid metabolic process / regulation of inflammatory response / regulation of mRNA stability / regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle / small GTPase mediated signal transduction / small molecule metabolic process / stimulatory C-type lectin receptor signaling pathway / T cell receptor signaling pathway / tumor necrosis factor-mediated signaling pathway / vascular endothelial growth factor receptor signaling pathway / viral processComponentscytoplasm / cytoplasmic mRNA processing body / cytosol / extracellular exosome / myofibril / nuclear matrix / nucleoplasm / nucleus / polysome / proteasome complex / proteasome core complex / proteasome core complex, alpha-subunit complex / sarcomere
- General Function
- Threonine-type endopeptidase activity
- Specific Function
- The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0012730|Proteasome subunit alpha type-6 (PSMA6) ATGACCGGAATGACAGCTGACAGCAGATCCCAGGTACAGAGGGCACGCTATGAGGCAGCT AACTGGAAATACAAGTATGGCTATGAGATTCCTGTGGACATGCTGTGTAAAAGAATTGCC GATATTTCTCAGGTCTACACACAGAATGCTGAAATGAGGCCTCTTGGTTGTTGTATGATT TTAATTGGTATAGATGAAGAGCAAGGCCCTCAGGTATATAAGTGTGATCCTGCAGGTTAC TACTGTGGGTTTAAAGCCACTGCAGCGGGAGTTAAACAAACTGAGTCAACCAGCTTCCTT GAAAAAAAAGTGAAGAAGAAATTTGATTGGACATTTGAACAGACAGTGGAAACTGCAATT ACATGCCTGTCTACTGTTCTATCAATTGATTTCAAACCTTCAGAAATAGAAGTTGGAGTA GTGACAGTTGAAAATCCTAAATTCAGGATTCTTACAGAAGCAGAGATTGATGCTCACCTT GTTGCTCTAGCAGAGAGAGACTAA
- Chromosome Location
- 14
- Locus
- 14q13
- External Identifiers
Resource Link UniProtKB ID P60900 UniProtKB Entry Name PSA6_HUMAN GenBank Protein ID 35682 GenBank Gene ID X59417 HGNC ID HGNC:9535 - General References
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