U6 snRNA-associated Sm-like protein LSm6

Details

Name
U6 snRNA-associated Sm-like protein LSm6
Synonyms
Not Available
Gene Name
LSM6
Organism
Humans
Amino acid sequence
>lcl|BSEQ0019566|U6 snRNA-associated Sm-like protein LSm6
MSLRKQTPSDFLKQIIGRPVVVKLNSGVDYRGVLACLDGYMNIALEQTEEYVNGQLKNKY
GDAFIRGNNVLYISTQKRRM
Number of residues
80
Molecular Weight
9127.525
Theoretical pI
Not Available
GO Classification
Functions
poly(A) RNA binding
Processes
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay / gene expression / maturation of SSU-rRNA / mRNA splicing, via spliceosome / nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay / RNA splicing / tRNA processing
Components
cytoplasmic mRNA processing body / cytosol / extracellular exosome / nucleolus / small nuclear ribonucleoprotein complex / small nucleolar ribonucleoprotein complex / spliceosomal complex / U4/U6 x U5 tri-snRNP complex / U6 snRNP
General Function
Poly(a) rna binding
Specific Function
Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0019567|U6 snRNA-associated Sm-like protein LSm6 (LSM6)
ATGAGTCTTCGGAAGCAAACCCCTAGTGACTTCTTAAAGCAAATCATCGGACGACCAGTT
GTGGTAAAATTAAATTCTGGAGTGGATTATCGAGGGGTCCTGGCTTGCCTGGATGGCTAC
ATGAATATAGCCCTGGAGCAGACAGAAGAATATGTAAATGGACAACTGAAGAATAAGTAT
GGGGATGCATTTATCCGAGGAAACAATGTGTTGTACATCAGTACACAGAAGAGACGGATG
TGA
Chromosome Location
4
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP62312
UniProtKB Entry NameLSM6_HUMAN
HGNC IDHGNC:17017
General References
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  2. Achsel T, Brahms H, Kastner B, Bachi A, Wilm M, Luhrmann R: A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro. EMBO J. 1999 Oct 15;18(20):5789-802. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB02745Uridineexperimental, investigationalunknownDetails
DB03685Uridine monophosphateexperimentalunknownDetails
DB04272Citric acidapproved, nutraceutical, vet_approvedunknownDetails