Ras-related protein Rab-11A

Details

Name
Ras-related protein Rab-11A
Synonyms
  • Rab-11
  • RAB11
  • YL8
Gene Name
RAB11A
Organism
Humans
Amino acid sequence
>lcl|BSEQ0009479|Ras-related protein Rab-11A
MGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTI
KAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADSNIVIM
LVGNKSDLRHLRAVPTDEARAFAEKNGLSFIETSALDSTNVEAAFQTILTEIYRIVSQKQ
MSDRRENDMSPSNNVVPIHVPPTTENKPKVQCCQNI
Number of residues
216
Molecular Weight
24393.305
Theoretical pI
Not Available
GO Classification
Functions
GTP binding / GTPase activity / microtubule binding / myosin V binding / syntaxin binding
Processes
astral microtubule organization / cytokinesis / establishment of protein localization to membrane / establishment of protein localization to organelle / establishment of vesicle localization / exosomal secretion / intracellular protein transport / melanosome transport / mitotic metaphase plate congression / mitotic spindle assembly / multivesicular body assembly / neuron projection development / organelle organization / plasma membrane to endosome transport / positive regulation of axon extension / positive regulation of epithelial cell migration / positive regulation of G2/M transition of mitotic cell cycle / protein localization to plasma membrane / Rab protein signal transduction / regulation of long-term neuronal synaptic plasticity / regulation of multivesicular body size / regulation of protein transport / regulation of vesicle-mediated transport / renal water homeostasis / transmembrane transport / vesicle-mediated transport / water transport
Components
axon / cleavage furrow / cytoplasmic vesicle / cytoplasmic vesicle membrane / cytosol / extracellular exosome / Golgi apparatus / mitochondrion / multivesicular body / perinuclear region of cytoplasm / phagocytic vesicle / phagocytic vesicle membrane / plasma membrane / protein complex / recycling endosome / recycling endosome membrane / spindle pole / trans-Golgi network / transport vesicle / vesicle
General Function
Syntaxin binding
Specific Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0021867|Ras-related protein Rab-11A (RAB11A)
ATGGGCACCCGCGACGACGAGTACGACTACCTCTTTAAAGTTGTCCTTATTGGAGATTCT
GGTGTTGGAAAGAGTAATCTCCTGTCTCGATTTACTCGAAATGAGTTTAATCTGGAAAGC
AAGAGCACCATTGGAGTAGAGTTTGCAACAAGAAGCATCCAGGTTGATGGAAAAACAATA
AAGGCACAGATATGGGACACAGCAGGGCAAGAGCGATATCGAGCTATAACATCAGCATAT
TATCGTGGAGCTGTAGGTGCCTTATTGGTTTATGACATTGCTAAACATCTCACATATGAA
AATGTAGAGCGATGGCTGAAAGAACTGAGAGATCATGCTGATAGTAACATTGTTATCATG
CTTGTGGGCAATAAGAGTGATCTACGTCATCTCAGGGCAGTTCCTACAGATGAAGCAAGA
GCTTTTGCAGAAAAGAATGAAGCAAATGTCAGACAGACGCGAAAATGA
Chromosome Location
15
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP62491
UniProtKB Entry NameRB11A_HUMAN
HGNC IDHGNC:9760
General References
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  7. Wallace DM, Lindsay AJ, Hendrick AG, McCaffrey MW: Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells. Biochem Biophys Res Commun. 2002 Dec 20;299(5):770-9. [Article]
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  9. Lindsay AJ, McCaffrey MW: Rab11-FIP2 functions in transferrin recycling and associates with endosomal membranes via its COOH-terminal domain. J Biol Chem. 2002 Jul 26;277(30):27193-9. Epub 2002 May 6. [Article]
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  15. Wilson GM, Fielding AB, Simon GC, Yu X, Andrews PD, Hames RS, Frey AM, Peden AA, Gould GW, Prekeris R: The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis. Mol Biol Cell. 2005 Feb;16(2):849-60. Epub 2004 Dec 15. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB018645'-Guanosine-Diphosphate-MonothiophosphateexperimentalunknownDetails
DB04315Guanosine-5'-DiphosphateexperimentalunknownDetails