Growth factor receptor-bound protein 2

Details

Name
Growth factor receptor-bound protein 2
Synonyms
  • Adapter protein GRB2
  • ASH
  • Protein Ash
  • SH2/SH3 adapter GRB2
Gene Name
GRB2
Organism
Humans
Amino acid sequence
>lcl|BSEQ0001826|Growth factor receptor-bound protein 2
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
Number of residues
217
Molecular Weight
25206.21
Theoretical pI
6.25
GO Classification
Functions
ephrin receptor binding / epidermal growth factor receptor binding / identical protein binding / insulin receptor substrate binding / neurotrophin TRKA receptor binding / poly(A) RNA binding / protein kinase binding / SH3 domain binding / SH3/SH2 adaptor activity
Processes
activation of MAPKK activity / aging / anatomical structure formation involved in morphogenesis / axon guidance / blood coagulation / branching involved in labyrinthine layer morphogenesis / cell-cell signaling / cellular response to ionizing radiation / epidermal growth factor receptor signaling pathway / Fc-epsilon receptor signaling pathway / Fc-gamma receptor signaling pathway involved in phagocytosis / fibroblast growth factor receptor signaling pathway / innate immune response / insulin receptor signaling pathway / leukocyte migration / MAPK cascade / negative regulation of epidermal growth factor receptor signaling pathway / neurotrophin TRK receptor signaling pathway / phosphatidylinositol-mediated signaling / platelet activation / positive regulation of actin filament polymerization / positive regulation of reactive oxygen species metabolic process / protein heterooligomerization / Ras protein signal transduction / receptor internalization / signal transduction in response to DNA damage / small GTPase mediated signal transduction / T cell costimulation / vascular endothelial growth factor receptor signaling pathway / viral process
Components
cell-cell junction / COP9 signalosome / cytoplasm / cytosol / endosome / extracellular exosome / Golgi apparatus / Grb2-EGFR complex / nucleolus / nucleoplasm / nucleus / plasma membrane / vesicle membrane
General Function
Sh3/sh2 adaptor activity
Specific Function
Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0020493|Growth factor receptor-bound protein 2 (GRB2)
ATGGAAGCCATCGCCAAATATGACTTCAAAGCTACTGCAGACGACGAGCTGAGCTTCAAA
AGGGGGGACATCCTCAAGGTTTTGAACGAAGAATGTGATCAGAACTGGTACAAGGCAGAG
CTTAATGGAAAAGACGGCTTCATTCCCAAGAACTACATAGAAATGAAACCACATCCGTGG
TTTTTTGGCAAAATCCCCAGAGCCAAGGCAGAAGAAATGCTTAGCAAACAGCGGCACGAT
GGGGCCTTTCTTATCCGAGAGAGTGAGAGCGCTCCTGGGGACTTCTCCCTCTCTGTCAAG
TTTGGAAACGATGTGCAGCACTTCAAGGTGCTCCGAGATGGAGCCGGGAAGTACTTCCTC
TGGGTGGTGAAGTTCAATTCTTTGAATGAGCTGGTGGATTATCACAGATCTACATCTGTC
TCCAGAAACCAGCAGATATTCCTGCGGGACATAGAACAGGTGCCACAGCAGCCGACATAC
GTCCAGGCCCTCTTTGACTTTGATCCCCAGGAGGATGGAGAGCTGGGCTTCCGCCGGGGA
GATTTTATCCATGTCATGGATAACTCAGACCCCAACTGGTGGAAAGGAGCTTGCCACGGG
CAGACCGGCATGTTTCCCCGCAATTATGTCACCCCCGTGAACCGGAACGTCTAA
Chromosome Location
17
Locus
17q24-q25
External Identifiers
ResourceLink
UniProtKB IDP62993
UniProtKB Entry NameGRB2_HUMAN
GenBank Protein ID181976
GenBank Gene IDM96995
GenAtlas IDGRB2
HGNC IDHGNC:4566
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB032764-[(10s,14s,18s)-18-(2-Amino-2-Oxoethyl)-14-(1-Naphthylmethyl)-8,17,20-Trioxo-7,16,19-Triazaspiro[5.14]Icos-11-En-10-Yl]Benzylphosphonic AcidexperimentalunknownDetails
DB00061PegademaseapprovedunknownbinderDetails