Pyrimidine-nucleoside phosphorylase
Details
- Name
- Pyrimidine-nucleoside phosphorylase
- Synonyms
- 2.4.2.2
- pyn
- PYNP
- Gene Name
- pdp
- Organism
- Geobacillus stearothermophilus
- Amino acid sequence
>lcl|BSEQ0012152|Pyrimidine-nucleoside phosphorylase MRMVDLIEKKRDGHALTKEEIQFIIEGYTKGDIPDYQMSALAMAIFFRGMNEEETAELTM AMVHSGDTIDLSRIEGIKVDKHSTGGVGDTTTLVLGPLVASVGVPVAKMSGRGLGHTGGT IDKLESVPGFHVEITNDEFIDLVNKNKIAVVGQSGNLTPADKKLYALRDVTATVNSIPLI ASSIMSKKIAAGADAIVLDVKTGVGAFMKDLNDAKALAKAMVDIGNRVGRKTMAIISDMS QPLGYAIGNALEVKEAIDTLKGEGPEDFQELCLVLGSHMVYLAEKASSLEEARHMLEKAM KDGSALQTFKTFLAAQGGDASVVDDPSKLPQAKYIIELEAKEDGYVSEIVADAVGTAAMW LGAGRATKESTIDLAVGLVLRKKVGDAVKKGESLVTIYSNREQVDDVKQKLYENIRISAT PVQAPTLIYDKIS
- Number of residues
- 433
- Molecular Weight
- 46331.92
- Theoretical pI
- 5.04
- GO Classification
- Functionsmetal ion binding / phosphorylase activity / pyrimidine-nucleoside phosphorylase activityProcessespyrimidine nucleobase metabolic process / pyrimidine nucleoside metabolic process
- General Function
- Pyrimidine-nucleoside phosphorylase activity
- Specific Function
- Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0006016|1302 bp ATGAGAATGGTCGATTTAATTGAGAAAAAACGTGATGGTCATGCGTTAACGAAAGAAGAA ATTCAGTTTATTATTGAAGGTTACACAAAAGGCGATATTCCTGATTATCAAATGAGCGCA TTAGCGATGGCGATTTTTTTCCGCGGCATGAATGAAGAAGAGACAGCGGAATTGACGATG GCGATGGTGCATTCAGGCGATACGATCGACCTTTCGCGAATTGAAGGAATTAAAGTAGAC AAACATTCAACGGGCGGAGTGGGCGATACAACAACGTTAGTGCTTGGCCCTCTTGTCGCC TCCGTCGGTGTTCCGGTTGCGAAAATGTCTGGGCGCGGCCTTGGACATACGGGTGGAACG ATCGACAAACTAGAATCGGTGCCAGGTTTTCACGTTGAAATTACGAACGATGAATTTATC GATCTTGTCAATAAAAATAAAATTGCCGTTGTCGGTCAGTCTGGTAATTTGACGCCAGCG GACAAAAAGTTGTATGCGCTTCGTGATGTGACGGCAACGGTCAATAGCATTCCGTTAATT GCCTCATCGATTATGAGCAAAAAAATTGCCGCAGGGGCAGATGCGATCGTACTTGACGTA AAAACAGGTGTGGGCGCGTTTATGAAAGATTTAAACGATGCAAAAGCATTAGCGAAAGCG ATGGTCGATATCGGAAATCGGGTTGGGCGTAAAACGATGGCAATTATTTCTGATATGAGC CAGCCGCTTGGTTATGCCATTGGAAATGCGCTTGAAGTGAAAGAAGCGATTGATACGTTA AAAGGAGAAGGTCCAGAAGATTTCCAAGAGCTGTGCTTAGTGCTTGGTAGCCACATGGTA TATTTAGCGGAAAAAGCATCTTCGCTTGAAGAAGCTCGTCATATGTTAGAAAAAGCGATG AAAGACGGTTCAGCCCTTCAAACATTTAAAACGTTCTTAGCTGCGCAAGGTGGCGATGCA TCTGTTGTCGATGACCCAAGCAAATTGCCGCAAGCAAAATATATTATTGAACTAGAAGCG AAAGAAGATGGATACGTATCCGAAATTGTCGCGGATGCGGTCGGAACGGCGGCGATGTGG CTTGGTGCAGGGCGAGCGACGAAAGAATCAACGATCGATTTAGCTGTCGGTCTCGTGCTT CGCAAAAAAGTCGGCGATGCGGTGAAAAAAGGTGAATCGCTCGTTACAATTTACAGCAAC CGTGAACAAGTGGATGATGTAAAACAAAAACTATATGAAAACATTCGTATTTCAGCAACA CCTGTTCAAGCTCCAACATTAATTTACGATAAAATTTCGTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P77836 UniProtKB Entry Name PDP_GEOSE GenBank Gene ID D87961 - General References
- Okuyama K, Hamamoto T, Noguchi T, Midorikawa Y: Molecular cloning and expression of the pyrimidine nucleoside phosphorylase gene from Bacillus stearothermophilus TH 6-2. Biosci Biotechnol Biochem. 1996 Oct;60(10):1655-9. [Article]
- Hamamoto T, Noguchi T, Midorikawa Y: Purification and characterization of purine nucleoside phosphorylase and pyrimidine nucleoside phosphorylase from Bacillus stearothermophilus TH 6-2. Biosci Biotechnol Biochem. 1996 Jul;60(7):1179-80. [Article]
- Pugmire MJ, Ealick SE: The crystal structure of pyrimidine nucleoside phosphorylase in a closed conformation. Structure. 1998 Nov 15;6(11):1467-79. [Article]