dTDP-epi-vancosaminyltransferase

Details

Name
dTDP-epi-vancosaminyltransferase
Synonyms
  • 2.4.1.311
  • Glycosyltransferase AH1
  • Glycosyltransferase GtfA
  • GtfAH1
Gene Name
gtfA
Organism
Amycolatopsis orientalis
Amino acid sequence
>lcl|BSEQ0022038|dTDP-epi-vancosaminyltransferase
MRVLITGCGSRGDTEPLVALAARLRELGADARMCLPPDYVERCAEVGVPMVPVGRAVRAG
AREPGELPPGAAEVVTEVVAEWFDKVPAAIEGCDAVVTTGLLPAAVAVRSMAEKLGIPYR
YTVLSPDHLPSEQSQAERDMYNQGADRLFGDAVNSHRASIGLPPVEHLYDYGYTDQPWLA
ADPVLSPLRPTDLGTVQTGAWILPDERPLSAELEAFLAAGSTPVYVGFGSSSRPATADAA
KMAIKAVRASGRRIVLSRGWADLVLPDDGADCFVVGEVNLQELFGRVAAAIHHDSAGTTL
LAMRAGIPQIVVRRVVDNVVEQAYHADRVAELGVGVAVDGPVPTIDSLSAALDTALAPEI
RARATTVADTIRADGTTVAAQLLFDAVSLEKPTVPA
Number of residues
396
Molecular Weight
41661.965
Theoretical pI
4.56
GO Classification
Functions
transferase activity, transferring hexosyl groups
Processes
lipid glycosylation / vancomycin biosynthetic process
General Function
Transferase activity, transferring hexosyl groups
Specific Function
Catalyzes the attachment of 4-epi-vancosamine from a TDP donor to the beta-OH-Tyr-6 of the aglycone cosubstrate in the biosynthesis of glycopeptide antibiotic chloroeremomycin, a member of the vancomycin group of antibiotics. Strongly prefers devancoaminyl-vancomycin (DVV) as substrate rather than the heptapeptide vancomycin aglycone (AGV). Acts downstream of GtfB.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0005516|1191 bp
ATGCGCGTGTTGATTACGGGGTGTGGATCGCGCGGAGATACCGAACCGTTGGTGGCATTG
GCGGCACGGTTGCGGGAACTCGGTGCGGACGCGCGGATGTGCCTGCCGCCGGACTACGTG
GAGCGGTGCGCCGAGGTCGGTGTGCCGATGGTGCCGGTCGGTCGGGCGGTGCGCGCAGGG
GCACGCGAGCCGGGAGAACTGCCGCCGGGGGCGGCCGAAGTCGTGACCGAGGTGGTCGCC
GAATGGTTCGACAAGGTCCCGGCGGCCATCGAGGGGTGTGACGCGGTGGTGACGACCGGC
TTGCTGCCCGCCGCGGTCGCTGTCCGGTCGATGGCCGAGAAGCTGGGCATCCCGTACCGC
TACACCGTGCTGTCTCCGGACCATCTGCCGTCGGAGCAAAGCCAGGCGGAGCGGGACATG
TACAACCAGGGCGCCGACAGGCTTTTCGGTGACGCGGTCAACAGCCACCGGGCCTCGATC
GGCCTGCCACCGGTGGAGCACCTCTACGACTACGGCTACACCGATCAGCCCTGGCTGGCG
GCGGACCCGGTGCTGTCCCCGCTGCGGCCGACGGACCTCGGCACTGTGCAGACCGGTGCG
TGGATCCTGCCCGACGAACGGCCGCTTTCCGCGGAGCTGGAGGCGTTTCTGGCTGCCGGG
TCGACGCCGGTGTACGTGGGTTTCGGCAGCTCGTCCCGACCGGCAACCGCTGACGCCGCG
AAGATGGCCATCAAGGCGGTCCGTGCCAGTGGCCGCCGGATCGTTCTCTCCCGCGGCTGG
GCCGATTTGGTCCTGCCGGACGACGGGGCCGACTGCTTCGTGGTCGGCGAAGTGAACCTT
CAGGAGCTGTTCGGCCGGGTGGCCGCCGCCATCCACCACGACAGCGCGGGCACGACGCTG
CTGGCCATGCGGGCGGGCATCCCCCAGATCGTGGTGCGCCGCGTAGTGGACAACGTGGTG
GAGCAGGCGTACCACGCCGACCGGGTGGCCGAGCTGGGTGTCGGTGTGGCGGTCGACGGT
CCGGTCCCGACCATCGACTCCTTGTCGGCCGCGCTCGACACGGCTCTGGCCCCGGAGATC
CGTGCGCGAGCGACGACCGTGGCAGACACGATTCGCGCCGATGGGACAACGGTGGCCGCG
CAGCTGCTGTTCGACGCGGTCAGCCTGGAAAAGCCGACTGTTCCCGCCTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP96558
UniProtKB Entry NameGTFA_AMYOR
GenBank Gene IDU84349
General References
  1. Solenberg PJ, Matsushima P, Stack DR, Wilkie SC, Thompson RC, Baltz RH: Production of hybrid glycopeptide antibiotics in vitro and in Streptomyces toyocaensis. Chem Biol. 1997 Mar;4(3):195-202. [Article]
  2. van Wageningen AM, Kirkpatrick PN, Williams DH, Harris BR, Kershaw JK, Lennard NJ, Jones M, Jones SJ, Solenberg PJ: Sequencing and analysis of genes involved in the biosynthesis of a vancomycin group antibiotic. Chem Biol. 1998 Mar;5(3):155-62. [Article]
  3. Lu W, Oberthur M, Leimkuhler C, Tao J, Kahne D, Walsh CT: Characterization of a regiospecific epivancosaminyl transferase GtfA and enzymatic reconstitution of the antibiotic chloroeremomycin. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4390-5. Epub 2004 Mar 18. [Article]
  4. Mulichak AM, Losey HC, Lu W, Wawrzak Z, Walsh CT, Garavito RM: Structure of the TDP-epi-vancosaminyltransferase GtfA from the chloroeremomycin biosynthetic pathway. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9238-43. Epub 2003 Jul 21. [Article]
  5. Truman AW, Dias MV, Wu S, Blundell TL, Huang F, Spencer JB: Chimeric glycosyltransferases for the generation of hybrid glycopeptides. Chem Biol. 2009 Jun 26;16(6):676-85. doi: 10.1016/j.chembiol.2009.04.013. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04529Desvancosaminyl vancomycinexperimentalunknownDetails