Holo-[acyl-carrier-protein] synthase

Details

Name
Holo-[acyl-carrier-protein] synthase
Synonyms
  • 2.7.8.7
  • 4'-phosphopantetheinyl transferase AcpS
  • Holo-ACP synthase
  • ydcB
Gene Name
acpS
Organism
Bacillus subtilis (strain 168)
Amino acid sequence
>lcl|BSEQ0019186|Holo-[acyl-carrier-protein] synthase
MIYGIGLDITELKRIASMAGRQKRFAERILTRSELDQYYELSEKRKNEFLAGRFAAKEAF
SKAFGTGIGRQLSFQDIEIRKDQNGKPYIICTKLSQAAVHVSITHTKEYAAAQVVIERLS
S
Number of residues
121
Molecular Weight
13717.63
Theoretical pI
10.08
GO Classification
Functions
holo-[acyl-carrier-protein] synthase activity / magnesium ion binding
Processes
fatty acid biosynthetic process
Components
cytoplasm
General Function
Magnesium ion binding
Specific Function
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of fatty acid acyl-carrier-protein ACP. Also modifies the D-alanyl carrier protein but fails to recognize PCP and AcpK, an acyl carrier protein of secondary metabolism.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0019187|Holo-[acyl-carrier-protein] synthase (acpS)
ATGATTTACGGCATTGGGCTGGACATTACCGAGCTTAAACGGATCGCCTCTATGGCTGGG
CGCCAGAAAAGGTTTGCCGAGCGGATTTTGACGCGAAGCGAGCTTGACCAATACTATGAG
CTTTCAGAGAAAAGAAAAAACGAATTTCTCGCGGGCAGATTCGCGGCAAAAGAAGCGTTC
TCGAAAGCATTTGGCACCGGCATTGGGAGGCAGCTCAGCTTTCAGGACATTGAAATTAGG
AAAGACCAAAATGGCAAGCCCTATATCATTTGTACGAAACTGAGCCAGGCCGCCGTTCAC
GTATCGATCACTCATACAAAAGAATACGCTGCCGCGCAGGTTGTGATTGAAAGGTTGTCA
AGCTAG
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP96618
UniProtKB Entry NameACPS_BACSU
GenBank Protein ID1881272
GenBank Gene IDAB001488
General References
  1. Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G, Azevedo V, Bertero MG, Bessieres P, Bolotin A, Borchert S, Borriss R, Boursier L, Brans A, Braun M, Brignell SC, Bron S, Brouillet S, Bruschi CV, Caldwell B, Capuano V, Carter NM, Choi SK, Cordani JJ, Connerton IF, Cummings NJ, Daniel RA, Denziot F, Devine KM, Dusterhoft A, Ehrlich SD, Emmerson PT, Entian KD, Errington J, Fabret C, Ferrari E, Foulger D, Fritz C, Fujita M, Fujita Y, Fuma S, Galizzi A, Galleron N, Ghim SY, Glaser P, Goffeau A, Golightly EJ, Grandi G, Guiseppi G, Guy BJ, Haga K, Haiech J, Harwood CR, Henaut A, Hilbert H, Holsappel S, Hosono S, Hullo MF, Itaya M, Jones L, Joris B, Karamata D, Kasahara Y, Klaerr-Blanchard M, Klein C, Kobayashi Y, Koetter P, Koningstein G, Krogh S, Kumano M, Kurita K, Lapidus A, Lardinois S, Lauber J, Lazarevic V, Lee SM, Levine A, Liu H, Masuda S, Mauel C, Medigue C, Medina N, Mellado RP, Mizuno M, Moestl D, Nakai S, Noback M, Noone D, O'Reilly M, Ogawa K, Ogiwara A, Oudega B, Park SH, Parro V, Pohl TM, Portelle D, Porwollik S, Prescott AM, Presecan E, Pujic P, Purnelle B, Rapoport G, Rey M, Reynolds S, Rieger M, Rivolta C, Rocha E, Roche B, Rose M, Sadaie Y, Sato T, Scanlan E, Schleich S, Schroeter R, Scoffone F, Sekiguchi J, Sekowska A, Seror SJ, Serror P, Shin BS, Soldo B, Sorokin A, Tacconi E, Takagi T, Takahashi H, Takemaru K, Takeuchi M, Tamakoshi A, Tanaka T, Terpstra P, Togoni A, Tosato V, Uchiyama S, Vandebol M, Vannier F, Vassarotti A, Viari A, Wambutt R, Wedler H, Weitzenegger T, Winters P, Wipat A, Yamamoto H, Yamane K, Yasumoto K, Yata K, Yoshida K, Yoshikawa HF, Zumstein E, Yoshikawa H, Danchin A: The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature. 1997 Nov 20;390(6657):249-56. [Article]
  2. Mootz HD, Finking R, Marahiel MA: 4'-phosphopantetheine transfer in primary and secondary metabolism of Bacillus subtilis. J Biol Chem. 2001 Oct 5;276(40):37289-98. Epub 2001 Aug 6. [Article]
  3. Parris KD, Lin L, Tam A, Mathew R, Hixon J, Stahl M, Fritz CC, Seehra J, Somers WS: Crystal structures of substrate binding to Bacillus subtilis holo-(acyl carrier protein) synthase reveal a novel trimeric arrangement of molecules resulting in three active sites. Structure. 2000 Aug 15;8(8):883-95. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01992Coenzyme Ainvestigational, nutraceuticalunknownDetails
DB044471,4-DithiothreitolexperimentalunknownDetails