2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase

Details

Name
2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase
Synonyms
Not Available
Gene Name
cumD
Organism
Pseudomonas fluorescens
Amino acid sequence
>lcl|BSEQ0022031|2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase
MANLEIGKSILAAGVLTNYHDVGEGQPVILIHGSGPGVSAYANWRLTIPALSKFYRVIAP
DMVGFGFTDRPENYNYSKDSWVDHIIGIMDALEIEKAHIVGNSFGGGLAIATALRYSERV
DRMVLMGAAGTRFDVTEGLNAVWGYTPSIENMRNLLDIFAYDRSLVTDELARLRYEASIQ
PGFQESFSSMFPEPRQRWIDALASSDEDIKTLPNETLIIHGREDQVVPLSSSLRLGELID
RAQLHVFGRCGHWTQIEQTDRFNRLVVEFFNEANTPKLVGRP
Number of residues
282
Molecular Weight
31489.385
Theoretical pI
5.03
GO Classification
Functions
hydrolase activity
General Function
Hydrolase activity
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0005375|849 bp
ATGGCAAACCTGGAAATAGGTAAAAGTATTTTAGCTGCAGGGGTTCTAACAAACTATCAC
GATGTCGGGGAGGGACAGCCTGTGATACTAATTCATGGTTCTGGGCCCGGCGTGAGCGCT
TATGCGAATTGGCGACTGACCATTCCTGCTCTGAGCAAGTTTTATCGTGTTATCGCCCCT
GATATGGTTGGTTTTGGCTTTACGGATCGACCTGAAAACTATAATTATTCCAAGGATAGT
TGGGTTGACCATATAATCGGTATTATGGACGCCCTGGAAATAGAAAAGGCTCACATCGTA
GGTAACTCATTCGGTGGGGGGCTGGCGATTGCTACCGCGCTTCGTTATTCGGAGCGCGTT
GATCGTATGGTTCTGATGGGGGCGGCCGGTACTCGCTTTGACGTGACAGAGGGCCTGAAC
GCGGTGTGGGGTTACACGCCGTCGATAGAAAACATGCGTAATCTCCTCGATATATTCGCT
TATGATCGCTCCTTAGTCACCGACGAATTAGCGAGACTTCGATATGAGGCGAGTATTCAG
CCAGGATTTCAAGAGTCATTCTCCAGCATGTTTCCTGAGCCGCGCCAACGCTGGATAGAC
GCGTTGGCTAGCTCGGATGAAGATATCAAGACTCTTCCCAATGAGACACTGATTATTCAT
GGTCGAGAGGATCAGGTTGTTCCTCTATCCAGCAGTCTGCGTCTAGGCGAACTTATCGAC
CGGGCGCAGTTGCATGTTTTCGGGCGATGTGGGCACTGGACACAAATTGAGCAGACTGAC
CGATTCAATCGTCTTGTGGTCGAGTTTTTTAATGAGGCCAACACACCTAAACTAGTGGGT
CGTCCGTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP96965
UniProtKB Entry NameP96965_PSEFL
GenBank Gene IDD83955
General References
  1. Fushinobu S, Saku T, Hidaka M, Jun SY, Nojiri H, Yamane H, Shoun H, Omori T, Wakagi T: Crystal structures of a meta-cleavage product hydrolase from Pseudomonas fluorescens IP01 (CumD) complexed with cleavage products. Protein Sci. 2002 Sep;11(9):2184-95. [Article]
  2. Fushinobu S, Jun SY, Hidaka M, Nojiri H, Yamane H, Shoun H, Omori T, Wakagi T: A series of crystal structures of a meta-cleavage product hydrolase from Pseudomonas fluorescens IP01 (CumD) complexed with various cleavage products. Biosci Biotechnol Biochem. 2005 Mar;69(3):491-8. [Article]
  3. Jun SY, Fushinobu S, Nojiri H, Omori T, Shoun H, Wakagi T: Improving the catalytic efficiency of a meta-cleavage product hydrolase (CumD) from Pseudomonas fluorescens IP01. Biochim Biophys Acta. 2006 Jul;1764(7):1159-66. Epub 2006 Jun 7. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB02406N-Valeric AcidexperimentalunknownDetails
DB02531Isobutyric acidexperimentalunknownDetails
DB03568Butyric Acidexperimental, investigationalunknownDetails
DB037412-Methylbutanoic AcidexperimentalunknownDetails
DB03750Isovaleric AcidexperimentalunknownDetails
DB03766Propanoic acidapproved, vet_approvedunknownDetails
DB03793Benzoic acidapproved, investigationalunknownDetails