Cyclin-dependent kinase-like 1

Details

Name
Cyclin-dependent kinase-like 1
Synonyms
  • 2.7.11.22
  • Protein kinase p42 KKIALRE
  • Serine/threonine-protein kinase KKIALRE
Gene Name
CDKL1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0051722|Cyclin-dependent kinase-like 1
MMEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLK
HPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHK
HNCIHRDVKPENILITKHSVIKLCDFGFARLLAGPSDYYTDYVATRWYRSPELLVGDTQY
GPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVK
IPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTQRLTCEQLLHHPYFENIREIEDLAKE
HNKPTRKTLRKSRKHHCFTETSKLQYLPQLTGSSILPALDNKKYYCDTKKLNYRFPNI
Number of residues
358
Molecular Weight
41802.175
Theoretical pI
Not Available
GO Classification
Functions
ATP binding / cyclin-dependent protein serine/threonine kinase activity
Processes
heart development / protein phosphorylation
Components
cytoplasm / extracellular exosome / intracellular membrane-bounded organelle / nucleoplasm / nucleus
General Function
Not Available
Specific Function
Atp binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0051723|Cyclin-dependent kinase-like 1 (CDKL1)
ATGATGGAGAAGTATGAAAAAATTGGGAAAATTGGAGAAGGATCCTATGGAGTTGTTTTC
AAATGTAGAAACAGGGACACGGGTCAGATTGTGGCCATCAAGAAGTTTCTGGAATCAGAA
GATGACCCTGTCATAAAGAAAATTGCCCTTCGGGAAATCCGAATGCTCAAGCAACTCAAG
CATCCCAACCTTGTTAACCTCCTGGAAGTCTTCAGGAGGAAACGGAGGCTTCACCTGGTG
TTTGAATATTGTGACCACACAGTTCTCCATGAGTTGGACAGATACCAAAGAGGGGTACCA
GAACATCTCGTGAAGAGCATAACTTGGCAGACACTGCAAGCTGTAAATTTTTGCCATAAA
CACAATTGCATACATAGAGACGTGAAGCCAGAAAATATCCTCATCACGAAACATTCCGTG
ATTAAGCTTTGTGACTTTGGATTTGCTCGGCTTTTGACTGGACCGAGTGACTACTATACA
GACTACGTGGCTACCAGGTGGTACCGCTCCCCTGAGCTGCTGGTGGGGGACACGCAGTAC
GGCCCCCCGGTGGATGTTTGGGCAATTGGCTGTGTCTTTGCTGAGCTGCTGTCAGGAGTG
CCTCTGTGGCCAGGAAAATCGGATGTGGATCAGCTGTATCTGATTAGGAAGACCTTGGGG
GATCTCATTCCTAGGCACCAGCAAGTGTTTAGCACGAATCAGTACTTCAGTGGAGTGAAA
ATTCCAGACCCTGAAGATATGGAACCACTTGAATTAAAATTCCCAAACATCTCTTATCCT
GCCCTGGGGCTCCTAAAGGGCTGTCTCCACATGGACCCTACTCAAAGGCTGACATGTGAA
CAGCTGTTGCATCACCCATATTTTGAAAACATCAGAGAAATAGAGGATTTGGCAAAAGAA
CACAACAAACCAACAAGGAAGACCCTAAGAAAGAGCCGAAAGCACCACTGCTTTACAGAA
ACATCCAAGTTGCAGTACCTACCCCAGCTAACTGGCAGCAGCATCCTTCCAGCTTTGGAT
AATAAGAAGTACTACTGTGATACCAAGAAACTTAACTACCGTTTTCCAAACATTTAA
Chromosome Location
14
Locus
14q21.3
External Identifiers
ResourceLink
UniProtKB IDQ00532
UniProtKB Entry NameCDKL1_HUMAN
HGNC IDHGNC:1781
General References
  1. Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai LH: A family of human cdc2-related protein kinases. EMBO J. 1992 Aug;11(8):2909-17. [Article]
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  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  5. Taglienti CA, Wysk M, Davis RJ: Molecular cloning of the epidermal growth factor-stimulated protein kinase p56 KKIAMRE. Oncogene. 1996 Dec 19;13(12):2563-74. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB12010Fostamatinibapproved, investigationalunknowninhibitorDetails