Dimethylaniline monooxygenase [N-oxide-forming] 1
Details
- Name
- Dimethylaniline monooxygenase [N-oxide-forming] 1
- Synonyms
- 1.14.13.8
- Dimethylaniline oxidase 1
- Fetal hepatic flavin-containing monooxygenase 1
- FMO 1
- Gene Name
- FMO1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0006944|Dimethylaniline monooxygenase [N-oxide-forming] 1 MAKRVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWRFTEHVEEGRASLYKSVVS NSCKEMSCYSDFPFPEDYPNYVPNSQFLEYLKMYANHFDLLKHIQFKTKVCSVTKCSDSA VSGQWEVVTMHEEKQESAIFDAVMVCTGFLTNPYLPLDSFPGINAFKGQYFHSRQYKHPD IFKDKRVLVIGMGNSGTDIAVEASHLAEKVFLSTTGGGWVISRIFDSGYPWDMVFMTRFQ NMLRNSLPTPIVTWLMERKINNWLNHANYGLIPEDRTQLKEFVLNDELPGRIITGKVFIR PSIKEVKENSVIFNNTSKEEPIDIIVFATGYTFAFPFLDESVVKVEDGQASLYKYIFPAH LQKPTLAIIGLIKPLGSMIPTGETQARWAVRVLKGVNKLPPPSVMIEEINARKENKPSWF GLCYCKALQSDYITYIDELLTYINAKPNLFSMLLTDPHLALTVFFGPCSPYQFRLTGPGK WEGARNAIMTQWDRTFKVIKARVVQESPSPFESFLKVFSFLALLVAIFLIFL
- Number of residues
- 532
- Molecular Weight
- 60310.285
- Theoretical pI
- 7.22
- GO Classification
- Functionsflavin adenine dinucleotide binding / monooxygenase activity / N,N-dimethylaniline monooxygenase activity / NADP bindingProcessesdrug metabolic process / NADPH oxidation / organic acid metabolic process / response to lipopolysaccharide / response to osmotic stress / small molecule metabolic process / toxin metabolic process / xenobiotic metabolic processComponentsendoplasmic reticulum lumen / endoplasmic reticulum membrane / integral component of membrane
- General Function
- Nadp binding
- Specific Function
- This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines.
- Pfam Domain Function
- FMO-like (PF00743)
- Transmembrane Regions
- Not Available
- Cellular Location
- Microsome membrane
- Gene sequence
>lcl|BSEQ0019446|Dimethylaniline monooxygenase [N-oxide-forming] 1 (FMO1) ATGCAGGAGAACATGGCCAAGCGAGTTGCCATTGTGGGAGCTGGGGTCAGCGGCCTGGCC TCCATCAAGTGCTGTCTGGAAGAAGGACTGGAGCCCACCTGCTTTGAGAGGAGCGATGAC CTTGGGGGGCTGTGGAGATTCACCGAACATGTTGAAGAAGGCAGAGCCAGTCTCTACAAG TCTGTGGTTTCCAACAGCTGCAAGGAGATGTCTTGTTACTCAGACTTTCCATTCCCAGAA GATTATCCAAACTATGTGCCAAATTCTCAATTCCTGGAATATCTCAAAATGTATGCAAAC CACTTTGACCTTCTGAAACACATTCAATTCAAGACCAAAGTCTGCAGTGTAACAAAATGC TCAGATTCTGCTGTCTCTGGCCAATGGGAGGTGGTCACTATGCATGAAGAGAAGCAAGAG TCAGCCATCTTTGATGCTGTCATGGTCTGCACTGGCTTTCTTACTAATCCTTATTTGCCA CTGGATTCCTTTCCAGGTATTAATGCCTTTAAAGGCCAGTACTTTCATAGCCGGCAATAT AAGCATCCAGATATATTTAAGGACAAGAGAGTCCTTGTGATTGGAATGGGAAATTCTGGC ACAGACATTGCTGTGGAGGCCAGCCACCTGGCGGAAAAGGTGTTCCTCAGCACCACCGGA GGGGGATGGGTGATCAGCCGAATCTTTGACTCGGGCTACCCATGGGACATGGTGTTCATG ACACGCTTTCAGAACATGTTGAGAAATTCCCTCCCAACCCCAATTGTGACTTGGTTGATG GAGCGAAAGATAAACAACTGGCTCAATCATGCAAATTACGGCTTAATACCAGAAGACAGG ACTCAGCTGAAAGAGTTTGTGCTAAATGATGAGCTCCCAGGACGCATCATCACTGGGAAA GTGTTCATCAGGCCAAGCATAAAAGAGGTAAAGGAAAACTCTGTCATATTTAACAATACT TCAAAGGAAGAGCCTATTGACATCATTGTCTTTGCCACTGGATACACATTTGCTTTCCCC TTCCTTGATGAGTCTGTAGTGAAAGTTGAAGATGGCCAGGCCTCACTGTACAAGTATATC TTCCCTGCACATCTGCAAAAGCCAACCCTGGCCATTATTGGCCTCATCAAACCCTTGGGC TCCATGATACCTACAGGAGAAACACAAGCTCGGTGGGCTGTTCGAGTCCTGAAAGGTGTA AATAAGTTACCACCACCAAGTGTCATGATAGAGGAAATTAATGCAAGGAAAGAAAACAAG CCCAGTTGGTTTGGCTTGTGCTACTGCAAGGCTTTACAATCAGATTATATCACATACATA GATGAACTCCTGACCTATATCAATGCAAAACCCAACCTGTTCTCTATGCTCCTAACGGAT CCACATCTGGCTCTGACCGTCTTCTTTGGCCCATGCTCACCATACCAGTTCCGCTTGACT GGCCCAGGAAAATGGGAAGGAGCCAGAAATGCCATCATGACCCAGTGGGACCGAACATTC AAGGTCATCAAAGCTCGAGTTGTACAAGAGTCTCCATCTCCCTTTGAAAGTTTTCTTAAA GTCTTTAGCTTTCTGGCTTTGCTTGTGGCTATTTTTCTGATTTTCCTATAA
- Chromosome Location
- 1
- Locus
- 1q23-q25
- External Identifiers
Resource Link UniProtKB ID Q01740 UniProtKB Entry Name FMO1_HUMAN GenBank Protein ID 182671 GenBank Gene ID M64082 HGNC ID HGNC:3769 - General References
- Dolphin C, Shephard EA, Povey S, Palmer CN, Ziegler DM, Ayesh R, Smith RL, Phillips IR: Cloning, primary sequence, and chromosomal mapping of a human flavin-containing monooxygenase (FMO1). J Biol Chem. 1991 Jul 5;266(19):12379-85. [Article]
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00675 Tamoxifen approved unknown substrate Details DB00582 Voriconazole approved unknown substrate Details DB00185 Cevimeline approved unknown substrate Details DB00501 Cimetidine approved, investigational unknown substrate Details DB04871 Lorcaserin approved, withdrawn no substrate Details DB05294 Vandetanib approved unknown substrate Details DB12278 Propiverine approved, investigational unknown substrate Details DB00768 Olopatadine approved no substrate Details DB13609 Umifenovir investigational unknown substrate Details DB15305 Risdiplam approved, investigational unknown substrate Details