Clavaminate synthase 1

Details

Name
Clavaminate synthase 1
Synonyms
  • 1.14.11.21
  • CAS1
  • Clavaminic acid synthase 1
  • CS1
Gene Name
cs1
Organism
Streptomyces clavuligerus (strain ATCC 27064 / DSM 738 / JCM 4710 / NBRC 13307 / NCIMB 12785 / NRRL 3585 / VKM Ac-602)
Amino acid sequence
>lcl|BSEQ0010917|Clavaminate synthase 1
MTSVDCTAYGPELRALAARLPRTPRADLYAFLDAAHTAAASLPGALATALDTFNAEGSED
GHLLLRGLPVEADADLPTTPSSTPAPEDRSLLTMEAMLGLVGRRLGLHTGYRELRSGTVY
HDVYPSPGAHHLSSETSETLLEFHTEMAYHRLQPNYVMLACSRADHERTAATLVASVRKA
LPLLDERTRARLLDRRMPCCVDVAFRGGVDDPGAIAQVKPLYGDADDPFLGYDRELLAPE
DPADKEAVAALSKALDEVTEAVYLEPGDLLIVDNFRTTHARTPFSPRWDGKDRWLHRVYI
RTDRNGQLSGGERAGDVVAFTPRG
Number of residues
324
Molecular Weight
35369.325
Theoretical pI
5.24
GO Classification
Functions
clavaminate synthase activity / iron ion binding
Processes
antibiotic biosynthetic process / clavulanic acid biosynthetic process
General Function
Iron ion binding
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0002609|975 bp
ATGACCTCAGTGGACTGCACCGCGTACGGCCCCGAGCTGCGCGCGCTCGCCGCCCGGCTG
CCCCGGACCCCCCGGGCCGACCTGTACGCCTTCCTGGACGCCGCGCACACAGCCGCCGCC
TCGCTCCCCGGCGCCCTCGCCACCGCGCTGGACACCTTCAACGCCGAGGGCAGCGAGGAC
GGCCATCTGCTGCTGCGCGGCCTCCCGGTGGAGGCCGACGCCGACCTCCCCACCACCCCG
AGCAGCACCCCGGCGCCCGAGGACCGCTCCCTGCTGACCATGGAGGCCATGCTCGGACTG
GTGGGCCGCCGGCTCGGTCTGCACACGGGGTACCGGGAGCTGCGCTCGGGCACGGTCTAC
CACGACGTGTACCCGTCGCCCGGCGCGCACCACCTGTCCTCGGAGACCTCCGAGACGCTG
CTGGAGTTCCACACGGAGATGGCCTACCACCGGCTCCAGCCGAACTACGTCATGCTGGCC
TGCTCCCGGGCCGACCACGAGCGCACGGCGGCCACACTCGTCGCCTCGGTCCGCAAGGCG
CTGCCCCTGCTGGACGAGAGGACCCGGGCCCGGCTCCTCGACCGGAGGATGCCCTGCTGC
GTGGATGTGGCCTTCCGCGGCGGGGTGGACGACCCGGGCGCCATCGCCCAGGTCAAACCG
CTCTACGGGGACGCGGACGATCCCTTCCTCGGGTACGACCGCGAGCTGCTGGCGCCGGAG
GACCCCGCGGACAAGGAGGCCGTCGCCGCCCTGTCCAAGGCGCTCGACGAGGTCACGGAG
GCGGTGTATCTGGAGCCCGGCGATCTGCTGATCGTCGACAACTTCCGCACCACGCACGCG
CGGACGCCGTTCTCGCCCCGCTGGGACGGGAAGGACCGCTGGCTGCACCGCGTCTACATC
CGCACCGACCGCAATGGACAGCTCTCCGGCGGCGAGCGCGCGGGCGACGTCGTCGCCTTC
ACACCGCGCGGCTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ05581
UniProtKB Entry NameCAS1_STRC2
GenBank Protein ID153220
GenBank Gene IDL06213
General References
  1. Marsh EN, Chang MD, Townsend CA: Two isozymes of clavaminate synthase central to clavulanic acid formation: cloning and sequencing of both genes from Streptomyces clavuligerus. Biochemistry. 1992 Dec 22;31(50):12648-57. [Article]
  2. Busby RW, Chang MD, Busby RC, Wimp J, Townsend CA: Expression and purification of two isozymes of clavaminate synthase and initial characterization of the iron binding site. General error analysis in polymerase chain reaction amplification. J Biol Chem. 1995 Mar 3;270(9):4262-9. [Article]
  3. Zhang Z, Ren J, Stammers DK, Baldwin JE, Harlos K, Schofield CJ: Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase. Nat Struct Biol. 2000 Feb;7(2):127-33. [Article]
  4. Zhang Z, Ren Js, Harlos K, McKinnon CH, Clifton IJ, Schofield CJ: Crystal structure of a clavaminate synthase-Fe(II)-2-oxoglutarate-substrate-NO complex: evidence for metal centered rearrangements. FEBS Lett. 2002 Apr 24;517(1-3):7-12. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01985N-acetyl-L-arginineexperimentalunknownDetails
DB02475Deoxyamidinoproclavaminic acidexperimentalunknownDetails