Mitogen-activated protein kinase kinase kinase 12

Details

Name

Mitogen-activated protein kinase kinase kinase 12

Synonyms

• 2.7.11.25
• DLK
• Dual leucine zipper bearing kinase
• Leucine-zipper protein kinase
• MAPK-upstream kinase
• Mixed lineage kinase
• MUK
• ZPK

Gene Name

MAP3K12

Organism

Humans

Amino acid sequence

>lcl|BSEQ0051806|Mitogen-activated protein kinase kinase kinase 12
MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGG
AAGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEV
PFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVC
TQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSP
NMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVL
WELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQI
LLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELR
HALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGL
LHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPSPGRS
RRGKTRHRKASAKGSCGDLPGLRTAVPPHEPGGPGSPGGLGGGPSAWEACPPALRGLHHD
LLLRKMSSSSPDLLSAALGSRGRGATGGAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGG
AKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHLTPAALLYRAAVTRSQKRGISSE
EEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSENPSDGEEGTASEPSPSGTPEVGSTNT
DERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPIPHQELLRERGPPNSEDSDCDST
ELDNSNSVDALRPPASLPP

Number of residues

859

Molecular Weight

93218.24

Theoretical pI

Not Available

GO Classification

Functions

ATP binding / MAP kinase kinase kinase activity / protein homodimerization activity / protein kinase activity / protein kinase binding / protein serine/threonine kinase activity / signal transducer activity

Processes

histone phosphorylation / intracellular signal transduction / JNK cascade / MAPK cascade / negative regulation of motor neuron apoptotic process / peptidyl-serine phosphorylation / peptidyl-threonine phosphorylation / protein autophosphorylation / protein phosphorylation

Components

cytoplasm / cytosol / growth cone / membrane / plasma membrane

General Function

May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro.

Specific Function

Atp binding

Pfam Domain Function

• PK_Tyr_Ser-Thr (PF07714)

Transmembrane Regions

Not Available

Cellular Location

Cytoplasm

Gene sequence

>lcl|BSEQ0051807|Mitogen-activated protein kinase kinase kinase 12 (MAP3K12)
ATGGCTTGCCTCCATGAGACCCGAACACCCTCTCCTTCCTTTGGGGGCTTTGTGTCTACC
CTAAGTGAGGCATCCATGCGCAAGCTGGACCCAGACACTTCTGACTGCACTCCCGAGAAG
GACCTGACGCCTACCCATGTCCTGCAGCTACATGAGCAGGATGCAGGGGGCCCAGGGGGA
GCAGCTGGGTCACCTGAGAGTCGGGCATCCAGAGTTCGAGCTGACGAGGTGCGACTGCAG
TGCCAGAGTGGCAGTGGCTTCCTTGAGGGCCTCTTTGGCTGCCTGCGCCCTGTCTGGACC
ATGATTGGCAAAGCCTACTCCACTGAGCACAAGCAGCAGCAGGAAGACCTTTGGGAGGTC
CCCTTTGAGGAAATCCTGGACCTGCAGTGGGTGGGCTCAGGGGCCCAGGGTGCTGTCTTC
CTGGGGCGCTTCCACGGGGAGGAGGTGGCTGTGAAGAAGGTGCGAGACCTCAAAGAAACC
GACATCAAGCACTTGCGAAAGCTGAAGCACCCCAACATCATCACTTTCAAGGGTGTGTGC
ACCCAGGCTCCCTGCTACTGCATCCTCATGGAGTTCTGCGCCCAGGGCCAGCTGTATGAG
GTACTGCGGGCTGGCCGCCCTGTCACCCCCTCCTTACTGGTTGACTGGTCCATGGGCATC
GCTGGTGGCATGAACTACCTGCACCTGCACAAGATTATCCACAGGGATCTCAAGTCACCC
AACATGCTAATCACCTACGACGATGTGGTGAAGATCTCAGATTTTGGCACTTCCAAGGAG
CTGAGTGACAAGAGCACCAAGATGTCCTTTGCAGGGACAGTAGCCTGGATGGCCCCTGAG
GTGATCCGCAATGAACCTGTGTCTGAGAAGGTCGACATCTGGTCCTTTGGCGTGGTGCTA
TGGGAACTGCTGACTGGTGAGATCCCCTACAAAGACGTAGATTCCTCAGCCATTATCTGG
GGTGTGGGAAGCAACAGTCTCCATCTGCCCGTGCCCTCCAGTTGCCCAGATGGTTTCAAG
ATCCTGCTTCGCCAGTGCTGGAATAGCAAACCACGAAATCGCCCATCATTCCGACAGATC
CTGCTGCATCTGGACATTGCCTCAGCTGATGTACTCTCCACACCCCAGGAGACTTACTTT
AAGTCCCAGGCAGAGTGGCGGGAAGAAGTAAAACTGCACTTTGAAAAGATTAAGTCAGAA
GGGACCTGTCTGCACCGCCTAGAAGAGGAACTGGTGATGAGGAGGAGGGAGGAGCTCAGA
CACGCCCTGGACATCAGGGAGCACTATGAAAGGAAGCTGGAGAGAGCCAACAACCTGTAT
ATGGAACTTAATGCCCTCATGTTGCAGCTGGAACTCAAGGAGAGGGAGCTGCTCAGGCGA
GAGCAAGCTTTAGAGCGGAGGTGCCCAGGCCTGCTGAAGCCACACCCTTCCCGGGGCCTC
CTGCATGGAAACACAATGGAGAAGCTTATCAAGAAGAGGAATGTGCCACAGAAGCTGTCA
CCCCATAGCAAAAGGCCAGATATCCTCAAGACGGAGTCTTTGCTCCCTAAACTAGATGCA
GCCCTGAGTGGGGTGGGGCTTCCTGGGTGTCCTAAGGGCCCCCCCTCACCAGGACGGAGT
CGCCGTGGCAAGACCCGTCACCGCAAGGCCAGCGCCAAGGGGAGCTGTGGGGACCTGCCT
GGGCTTCGTACAGCTGTGCCACCCCATGAACCTGGAGGACCAGGAAGCCCAGGGGGCCTA
GGAGGGGGACCCTCAGCCTGGGAGGCCTGCCCTCCCGCCCTCCGTGGGCTTCATCATGAC
CTCCTGCTCCGCAAAATGTCTTCATCGTCCCCAGACCTGCTGTCAGCAGCACTAGGGTCC
CGGGGCCGGGGGGCCACAGGCGGAGCTGGGGATCCTGGCTCACCACCTCCGGCCCGGGGT
GACACCCCACCAAGTGAGGGCTCAGCCCCTGGCTCCACCAGCCCAGATTCACCTGGGGGA
GCCAAAGGGGAACCACCTCCTCCAGTAGGGCCTGGTGAAGGTGTGGGGCTTCTGGGAACT
GGAAGGGAAGGGACCTCAGGCCGGGGAGGAAGCCGGGCTGGGTCCCAGCACTTGACCCCA
GCTGCACTGCTGTACAGGGCTGCCGTCACCCGAAGTCAGAAACGTGGCATCTCATCGGAA
GAGGAGGAAGGAGAGGTAGACAGTGAAGTAGAGCTGACATCAAGCCAGAGGTGGCCTCAG
AGCCTGAACATGCGCCAGTCACTATCTACCTTCAGCTCAGAGAATCCATCAGATGGGGAG
GAAGGCACAGCTAGTGAACCTTCCCCCAGTGGCACACCTGAAGTTGGCAGCACCAACACT
GATGAGCGGCCAGATGAGCGGTCTGATGACATGTGCTCCCAGGGCTCAGAAATCCCACTG
GACCCACCTCCTTCAGAGGTCATCCCTGGCCCTGAACCCAGCTCCCTGCCCATTCCACAC
CAGGAACTTCTCAGAGAGCGGGGCCCTCCCAATTCTGAGGACTCAGACTGTGACAGCACT
GAATTGGACAACTCCAACAGCGTTGATGCCTTGCGGCCCCCAGCTTCCCTCCCTCCATGA

Chromosome Location

12

Locus

12q13.13

External Identifiers

Resource	Link
UniProtKB ID	Q12852
UniProtKB Entry Name	M3K12_HUMAN
HGNC ID	HGNC:6851

General References

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Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB12010	Fostamatinib	approved, investigational	unknown	inhibitor	Details