Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform

Details

Name
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
Synonyms
  • KIAA0044
  • PP2A B subunit isoform B'-gamma
  • PP2A B subunit isoform B56-gamma
  • PP2A B subunit isoform PR61-gamma
  • PP2A B subunit isoform R5-gamma
  • Renal carcinoma antigen NY-REN-29
Gene Name
PPP2R5C
Organism
Humans
Amino acid sequence
>lcl|BSEQ0007198|Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
MLTCNKAGSRMVVDAANSNGPFQPVVLLHIRDVPPADQEKLFIQKLRQCCVLFDFVSDPL
SDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEVVHMFAVNMFRTLPPSSNPTGAEFDP
EEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLQLLELFDSEDPRERD
FLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAELLEILGSIINGFALPLK
EEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEPVVMALLKYWPKTHSPK
EVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLIS
DNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQFKAEKLKEK
LKMKEREEAWVKIENLAKANPQYTVYSQASTMSIPVAMETDGPLFEDVQMLRKTVKDEAH
QAQKDPKKDRPLARRKSELPQDPHTKKALEAHCRADELASQDGR
Number of residues
524
Molecular Weight
61060.235
Theoretical pI
6.87
GO Classification
Functions
protein phosphatase type 2A regulator activity
Processes
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest / intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / negative regulation of cell proliferation / proteasome-mediated ubiquitin-dependent protein catabolic process / regulation of protein phosphatase type 2A activity / signal transduction
Components
chromosome, centromeric region / nucleus / protein phosphatase type 2A complex
General Function
Protein phosphatase type 2a regulator activity
Specific Function
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0019467|Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PPP2R5C)
ATGCCGAATAAAAACAAGAAGGAGAAAGAATCACCAAAAGCAGGGAAGAGTGGAAAAAGT
TCAAAAGAAGGACAAGACACAGTAGAATCAGAGGGAACAAGTCCTGAAGAACCCTCAAGC
CCTAAAGTACCACCTCCACTTCTTCCTGAGTTGCTGGTTCTTATTTTTGGTGGGCTTCAA
GGAAGAGATGTTCCTCCTGCTGATCAAGAGAAGCTTTTTATCCAGAAGTTACGTCAGTGT
TGCGTCCTCTTTGACTTTGTTTCTGATCCACTAAGTGACCTAAAGTGGAAGGAAGTAAAA
CGAGCTGCTTTAAGTGAAATGGTAGAATATATCACCCATAATCGGAATGTGATCACAGAG
CCTATTTACCCAGAAGTAGTCCATATGTTTGCAGTTAACATGTTTCGAACATTACCACCT
TCCTCCAATCCTACGGGAGCGGAATTTGACCCGGAGGAAGATGAACCAACGTTAGAAGCA
GCCTGGCCTCATCTACAGCTTGTTTATGAATTTTTCTTAAGATTTTTAGAGTCTCCAGAT
TTCCAACCTAATATAGCGAAGAAATATATTGATCAGAAGTTTGTATTGCAGCTTTTAGAG
CTCTTTGACAGTGAAGATCCTCGGGAGAGAGATTTTCTTAAAACCACCCTTCACAGAATC
TATGGGAAATTCCTAGGCTTGAGAGCTTACATCAGAAAACAGATAAATAATATATTTTAT
AGGTTTATTTATGAAACAGAGCATCATAATGGCATAGCAGAGTTACTGGAAATATTGGGA
AGTATAATTAATGGATTTGCCTTACCACTAAAAGAAGAGCACAAGATTTTCTTATTGAAG
GTGTTACTACCTTTGCACAAAGTGAAATCTCTGAGTGTCTACCATCCCCAGCTGGCATAC
TGTGTAGTGCAGTTTTTAGAAAAGGACAGCACCCTCACGGAACCAGTGGTGATGGCACTT
CTCAAATACTGGCCAAAGACTCACAGTCCAAAAGAAGTAATGTTCTTAAACGAATTAGAA
GAGATTTTAGATGTCATTGAACCATCAGAATTTGTGAAGATCATGGAACCCCTCTTCCGG
CAGTTGGCCAAATGTGTCTCCAGCCCACACTTCCAGGTGGCAGAGCGAGCTCTCTATTAC
TGGAATAATGAATACATCATGAGTTTAATCAGTGACAACGCAGCGAAGATTCTGCCCATC
ATGTTTCCTTCCTTGTACCGCAACTCAAAGACCCATTGGAACAAGACAATACATGGCTTG
ATATACAACGCCCTGAAGCTCTTCATGGAGATGAACCAAAAGCTATTTGATGACTGTACA
CAACAGTTCAAAGCAGAGAAACTAAAAGAGAAGCTAAAAATGAAAGAACGGGAAGAAGCA
TGGGTTAAAATAGAAAATCTAGCCAAAGCCAATCCCCAGTACACAGTGTATAGTCAAGCC
AGCACCATGAGCATTCCGGTTGCAATGGAGACAGATGGGCCTTTATTTGAAGATGTGCAG
ATGCTGAGAAAGACAGTGAAGGACGAGGCTCATCAGGCACAGAAAGATCCGAAGAAGGAC
CGTCCTCTTGCACGCCGCAAGTCCGAGCTGCCTCAGGACCCCCACACCAAGAAAGCCTTG
GAAGCTCACTGCAGGGCCGATGAGCTGGCCTCCCAGGACGGCCGCTAG
Chromosome Location
14
Locus
14q32.31
External Identifiers
ResourceLink
UniProtKB IDQ13362
UniProtKB Entry Name2A5G_HUMAN
GenBank Protein ID1203812
GenBank Gene IDU37352
HGNC IDHGNC:9311
General References
  1. Tehrani MA, Mumby MC, Kamibayashi C: Identification of a novel protein phosphatase 2A regulatory subunit highly expressed in muscle. J Biol Chem. 1996 Mar 1;271(9):5164-70. [Article]
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  6. Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S: Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. DNA Res. 1994;1(5):223-9. [Article]
  7. McCright B, Virshup DM: Identification of a new family of protein phosphatase 2A regulatory subunits. J Biol Chem. 1995 Nov 3;270(44):26123-8. [Article]
  8. McCright B, Rivers AM, Audlin S, Virshup DM: The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm. J Biol Chem. 1996 Sep 6;271(36):22081-9. [Article]
  9. Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jager D, Jager E, Knuth A, Chen YT, Old LJ: Antigens recognized by autologous antibody in patients with renal-cell carcinoma. Int J Cancer. 1999 Nov 12;83(4):456-64. [Article]
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  11. Letourneux C, Rocher G, Porteu F: B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK. EMBO J. 2006 Feb 22;25(4):727-38. Epub 2006 Feb 2. [Article]
  12. Kitajima TS, Sakuno T, Ishiguro K, Iemura S, Natsume T, Kawashima SA, Watanabe Y: Shugoshin collaborates with protein phosphatase 2A to protect cohesin. Nature. 2006 May 4;441(7089):46-52. Epub 2006 Mar 15. [Article]
  13. Li HH, Cai X, Shouse GP, Piluso LG, Liu X: A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55. EMBO J. 2007 Jan 24;26(2):402-11. [Article]
  14. Shouse GP, Cai X, Liu X: Serine 15 phosphorylation of p53 directs its interaction with B56gamma and the tumor suppressor activity of B56gamma-specific protein phosphatase 2A. Mol Cell Biol. 2008 Jan;28(1):448-56. Epub 2007 Oct 29. [Article]
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  19. Magnusdottir A, Stenmark P, Flodin S, Nyman T, Kotenyova T, Graslund S, Ogg D, Nordlund P: The structure of the PP2A regulatory subunit B56 gamma: the remaining piece of the PP2A jigsaw puzzle. Proteins. 2009 Jan;74(1):212-21. doi: 10.1002/prot.22150. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB06905(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acidexperimentalunknownDetails
DB025062,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic AcidexperimentalunknownDetails