Meiotic recombination protein DMC1/LIM15 homolog

Details

Name
Meiotic recombination protein DMC1/LIM15 homolog
Synonyms
  • DMC1H
  • LIM15
Gene Name
DMC1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0009368|Meiotic recombination protein DMC1/LIM15 homolog
MKEDQVVAEEPGFQDEEESLFQDIDLLQKHGINVADIKKLKSVGICTIKGIQMTTRRALC
NVKGLSEAKVDKIKEAANKLIEPGFLTAFEYSEKRKMVFHITTGSQEFDKLLGGGIESMA
ITEAFGEFRTGKTQLSHTLCVTAQLPGAGGYPGGKIIFIDTENTFRPDRLRDIADRFNVD
HDAVLDNVLYARAYTSEHQMELLDYVAAKFHEEAGIFKLLIIDSIMALFRVDFSGRGELA
ERQQKLAQMLSRLQKISEEYNVAVFVTNQMTADPGATMTFQADPKKPIGGHILAHASTTR
ISLRKGRGELRIAKIYDSPEMPENEATFAITAGGIGDAKE
Number of residues
340
Molecular Weight
37680.725
Theoretical pI
Not Available
GO Classification
Functions
ATP binding / DNA binding / DNA-dependent ATPase activity / double-stranded DNA binding / four-way junction DNA binding / recombinase activity / single-stranded DNA binding
Processes
chromosome organization involved in meiotic cell cycle / DNA recombinase assembly / female gamete generation / male meiosis I / meiotic nuclear division / mitotic recombination / oocyte maturation / ovarian follicle development / reciprocal meiotic recombination / response to ionizing radiation / spermatid development / spermatogenesis / strand invasion / synapsis
Components
chromosome / chromosome, telomeric region / condensed nuclear chromosome / nucleoplasm / nucleus
General Function
Single-stranded dna binding
Specific Function
May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0013115|Meiotic recombination protein DMC1/LIM15 homolog (DMC1)
ATGAAGGAGGATCAAGTTGTGGCGGAAGAACCAGGATTCCAAGATGAAGAGGAATCTTTG
TTTCAAGATATTGACCTGTTACAGAAACATGGAATTAACGTGGCTGACATTAAGAAACTG
AAATCAGTAGGAATCTGTACCATCAAAGGTATACAGATGACAACAAGAAGAGCTCTATGC
AATGTCAAAGGACTCTCAGAAGCCAAAGTAGACAAGATTAAAGAGGCAGCGAACAAACTA
ATTGAACCAGGATTCTTGACTGCATTTGAGTATAGTGAAAAGAGGAAAATGGTTTTCCAT
ATCACCACCGGGAGCCAGGAATTTGATAAGTTACTAGGAGGTGGAATTGAAAGTATGGCA
ATTACAGAAGCTTTTGGAGAATTTCGTACTGGAAAAACCCAGCTTTCTCATACCCTCTGT
GGTGAACATCAGATGGAGCTACTTGATTATGTAGCAGCAAAGTTCCATGAAGAAGCTGGC
ATCTTCAAGCTATTGATTATCGATTCAATAATGGCACTTTTTCGAGTGGATTTCAGTGGC
CGTGGGGAGTTGGCCGAACGGCAGCAAAAATTGGCCCAGATGTTGTCACGACTCCAAAAA
ATCTCAGAAGAATATAACGTGGCTGTTTTTGTGACCAATCAAATGACTGCCGATCCAGGA
GCAACTATGACCTTTCAGGCAGATCCCAAAAAACCCATTGGGGGACACATTCTGGCTCAT
GCTTCAACAACAAGAATAAGCTTGCGAAAGGGAAGAGGAGAGCTCAGAATTGCCAAGATT
TATGACAGTCCTGAGATGCCTGAAAATGAAGCCACCTTCGCAATAACTGCTGGAGGAATT
GGGGATGCCAAGGAGTAG
Chromosome Location
22
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ14565
UniProtKB Entry NameDMC1_HUMAN
HGNC IDHGNC:2927
General References
  1. Sato S, Seki N, Hotta Y, Tabata S: Expression profiles of a human gene identified as a structural homologue of meiosis-specific recA-like genes. DNA Res. 1995 Aug 31;2(4):183-6. [Article]
  2. Habu T, Taki T, West A, Nishimune Y, Morita T: The mouse and human homologs of DMC1, the yeast meiosis-specific homologous recombination gene, have a common unique form of exon-skipped transcript in meiosis. Nucleic Acids Res. 1996 Feb 1;24(3):470-7. [Article]
  3. Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I: A genome annotation-driven approach to cloning the human ORFeome. Genome Biol. 2004;5(10):R84. Epub 2004 Sep 30. [Article]
  4. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  5. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al.: The DNA sequence of human chromosome 22. Nature. 1999 Dec 2;402(6761):489-95. [Article]
  6. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  7. Jensen RB, Carreira A, Kowalczykowski SC: Purified human BRCA2 stimulates RAD51-mediated recombination. Nature. 2010 Oct 7;467(7316):678-83. doi: 10.1038/nature09399. [Article]
  8. Kinebuchi T, Kagawa W, Enomoto R, Tanaka K, Miyagawa K, Shibata T, Kurumizaka H, Yokoyama S: Structural basis for octameric ring formation and DNA interaction of the human homologous-pairing protein Dmc1. Mol Cell. 2004 May 7;14(3):363-74. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB03366Imidazoleexperimental, investigationalunknownDetails