Metabotropic glutamate receptor 7

Details

Name
Metabotropic glutamate receptor 7
Synonyms
  • GPRC1G
  • MGLUR7
Gene Name
GRM7
Organism
Humans
Amino acid sequence
>lcl|BSEQ0001664|Metabotropic glutamate receptor 7
MVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAK
GPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSL
TFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYA
STAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQ
ISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAK
RADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRR
NVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAH
ALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIF
QYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTP
CCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAML
GIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRV
FLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIW
FGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGV
PENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGML
YMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNS
PAAKKKYVSYNNLVI
Number of residues
915
Molecular Weight
102250.06
Theoretical pI
7.94
GO Classification
Functions
adenylate cyclase inhibitor activity / calcium channel regulator activity / calcium ion binding / glutamate binding / glutamate receptor activity / group III metabotropic glutamate receptor activity / PDZ domain binding / serine binding / voltage-gated calcium channel activity
Processes
adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway / adult behavior / conditioned taste aversion / multicellular organismal response to stress / negative regulation of adenylate cyclase activity / negative regulation of cAMP biosynthetic process / negative regulation of glutamate secretion / regulation of cyclase activity / regulation of synaptic transmission, glutamatergic / sensory perception of smell / sensory perception of sound / short-term memory / synaptic transmission / transmission of nerve impulse
Components
asymmetric synapse / axon / cell cortex / dendrite / dendritic shaft / integral component of membrane / integral component of plasma membrane / plasma membrane / postsynaptic membrane / presynaptic active zone / presynaptic membrane / receptor complex
General Function
Voltage-gated calcium channel activity
Specific Function
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
Pfam Domain Function
Transmembrane Regions
591-615 628-648 655-675 703-723 754-775 789-810 826-850
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0021276|Metabotropic glutamate receptor 7 (GRM7)
ATGGTCCAGCTGAGGAAGCTGCTCCGCGTCCTGACTTTGATGAAGTTCCCCTGCTGCGTG
CTGGAGGTGCTCCTGTGCGCGCTGGCGGCGGCGGCGCGCGGCCAGGAGATGTACGCCCCG
CACTCAATCCGGATCGAGGGGGACGTCACCCTCGGGGGGCTGTTCCCCGTGCACGCCAAG
GGTCCCAGCGGAGTGCCCTGCGGCGACATCAAGAGGGAAAACGGGATCCACAGGCTGGAA
GCGATGCTCTACGCCCTGGACCAGATCAACAGTGATCCCAACCTACTGCCCAACGTGACG
CTGGGCGCGCGGATCCTGGACACTTGTTCCAGGGACACTTACGCGCTCGAACAGTCGCTT
ACTTTCGTCCAGGCGCTCATCCAGAAGGACACCTCCGACGTGCGCTGCACCAACGGCGAA
CCGCCGGTTTTCGTCAAGCCGGAGAAAGTAGTTGGAGTGATTGGGGCTTCGGGGAGTTCG
GTCTCCATCATGGTAGCCAACATCCTGAGGCTCTTCCAGATCCCCCAGATTAGTTATGCA
TCAACGGCACCCGAGCTAAGTGATGACCGGCGCTATGACTTCTTCTCTCGCGTGGTGCCA
CCCGATTCCTTCCAAGCCCAGGCCATGGTAGACATTGTAAAGGCCCTAGGCTGGAATTAT
GTGTCTACCCTCGCATCGGAAGGAAGTTATGGAGAGAAAGGTGTGGAGTCCTTCACGCAG
ATTTCCAAAGAGGCAGGTGGACTCTGCATTGCCCAGTCCGTGAGAATCCCCCAGGAACGC
AAAGACAGGACCATTGACTTTGATAGAATTATCAAACAGCTCCTGGACACCCCCAACTCC
AGGGCCGTCGTGATTTTTGCCAACGATGAGGATATAAAGCAGATCCTTGCAGCAGCCAAA
AGAGCTGACCAAGTTGGCCATTTTCTTTGGGTGGGATCAGACAGCTGGGGATCCAAAATA
AACCCACTGCACCAGCATGAAGATATCGCAGAAGGGGCCATCACCATTCAGCCCAAGCGA
GCCACGGTGGAAGGGTTTGATGCCTACTTTACGTCCCGTACACTTGAAAACAACAGAAGA
AATGTATGGTTTGCCGAATACTGGGAGGAAAACTTCAACTGCAAGTTGACGATTAGTGGG
TCAAAAAAAGAAGACACAGATCGCAAATGCACAGGACAGGAGAGAATTGGAAAAGATTCC
AACTATGAGCAGGAGGGTAAAGTCCAGTTCGTGATTGACGCAGTCTATGCTATGGCTCAC
GCCCTTCACCACATGAACAAGGATCTCTGTGCTGACTACCGGGGTGTCTGCCCAGAGATG
GAGCAAGCTGGAGGCAAGAAGTTGCTGAAGTATATACGCAATGTTAATTTCAATGGTAGT
GCTGGCACTCCAGTGATGTTTAACAAGAACGGGGATGCACCTGGGCGTTATGACATCTTT
CAGTACCAGACCACAAACACCAGCAACCCGGGTTACCGTCTGATCGGGCAGTGGACAGAC
GAACTTCAGCTCAATATAGAAGACATGCAGTGGGGTAAAGGAGTCCGAGAGATACCCGCC
TCAGTGTGCACACTACCATGTAAGCCAGGACAGAGAAAGAAGACACAGAAAGGAACTCCT
TGCTGTTGGACCTGTGAGCCTTGCGATGGTTACCAGTACCAGTTTGATGAGATGACATGC
CAGCATTGCCCCTATGACCAGAGGCCCAATGAAAATCGAACCGGATGCCAGGATATTCCC
ATCATCAAACTGGAGTGGCACTCCCCCTGGGCTGTGATTCCTGTCTTCCTGGCAATGTTG
GGGATCATTGCCACCATCTTTGTCATGGCCACTTTCATCCGCTACAATGACACGCCCATT
GTCCGGGCATCTGGGCGGGAACTCAGCTATGTTCTTTTGACGGGCATCTTTCTTTGCTAC
ATCATCACTTTCCTGATGATTGCCAAACCAGATGTGGCAGTGTGTTCTTTCCGGCGAGTT
TTCTTGGGCTTGGGTATGTGCATCAGTTATGCAGCCCTCTTGACGAAAACAAATCGGATT
TATCGCATATTTGAGCAGGGCAAGAAATCAGTAACAGCTCCCAGACTCATAAGCCCAACA
TCACAACTGGCAATCACTTCCAGTTTAATATCAGTTCAGCTTCTAGGGGTGTTCATTTGG
TTTGGTGTTGATCCACCCAACATCATCATAGACTATGATGAACACAAGACAATGAACCCT
GAGCAAGCCAGAGGGGTTCTCAAGTGTGACATTACAGATCTCCAAATCATTTGCTCCTTG
GGATATAGCATTCTTCTCATGGTCACATGTACTGTGTATGCCATCAAGACTCGGGGTGTA
CCCGAGAATTTTAACGAAGCCAAGCCCATTGGATTCACTATGTACACGACATGTATAGTA
TGGCTTGCCTTCATTCCAATTTTTTTTGGCACCGCTCAATCAGCGGAAAAGCTCTACATA
CAAACTACCACGCTTACAATCTCCATGAACCTAAGTGCATCAGTGGCGCTGGGGATGCTA
TACATGCCGAAAGTGTACATCATCATTTTCCACCCTGAACTCAATGTCCAGAAACGGAAG
CGAAGCTTCAAGGCGGTAGTCACAGCAGCCACCATGTCATCGAGGCTGTCACACAAACCC
AGTGACAGACCCAACGGTGAGGCAAAGACCGAGCTCTGTGAAAACGTAGACCCAAACAGC
CCTGCTGCAAAAAAGAAGTATGTCAGTTATAATAACCTGGTTATCTAA
Chromosome Location
3
Locus
3p26.1-p25.1
External Identifiers
ResourceLink
UniProtKB IDQ14831
UniProtKB Entry NameGRM7_HUMAN
GenBank Protein ID1370111
GenBank Gene IDX94552
GenAtlas IDGRM7
HGNC IDHGNC:4599
General References
  1. Makoff A, Pilling C, Harrington K, Emson P: Human metabotropic glutamate receptor type 7: molecular cloning and mRNA distribution in the CNS. Brain Res Mol Brain Res. 1996 Aug;40(1):165-70. [Article]
  2. Flor PJ, Van Der Putten H, Ruegg D, Lukic S, Leonhardt T, Bence M, Sansig G, Knopfel T, Kuhn R: A novel splice variant of a metabotropic glutamate receptor, human mGluR7b. Neuropharmacology. 1997 Feb;36(2):153-9. [Article]
  3. Wu S, Wright RA, Rockey PK, Burgett SG, Arnold JS, Rosteck PR Jr, Johnson BG, Schoepp DD, Belagaje RM: Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells. Brain Res Mol Brain Res. 1998 Jan;53(1-2):88-97. [Article]
  4. Schulz HL, Stohr H, Weber BH: Characterization of three novel isoforms of the metabotrobic glutamate receptor 7 (GRM7). Neurosci Lett. 2002 Jun 21;326(1):37-40. [Article]
  5. Bolonna AA, Kerwin RW, Munro J, Arranz MJ, Makoff AJ: Polymorphisms in the genes for mGluR types 7 and 8: association studies with schizophrenia. Schizophr Res. 2001 Jan 15;47(1):99-103. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00142Glutamic acidapproved, nutraceuticalunknownDetails