Inactive phospholipase C-like protein 1

Details

Name
Inactive phospholipase C-like protein 1
Synonyms
  • Phospholipase C-deleted in lung carcinoma
  • Phospholipase C-related but catalytically inactive protein
  • PLC-L1
  • PRIP
Gene Name
PLCL1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0037121|Inactive phospholipase C-like protein 1
MAEGAAGREDPAPPDAAGGEDDPRVGPDAAGDCVTAASGGRMRDRRSGVALPGAAGTPAD
SEAGLLEAARATPRRSSIIKDPSNQKCGGRKKTVSFSSMPSEKKISSANDCISFMQAGCE
LKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGKNTETFRNNGL
ADQICEDCAFSILHGENYESLDLVANSADVANIWVSGLRYLVSRSKQPLDFMEGNQNTPR
FMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEAKIRLKFKEIQKSKEKLTTRVTE
EEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLFLEAEQGVTHITEDICLDIIRRY
ELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYINASHNTYLIED
QFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSFRSVIEVINKFAF
VASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTEAPLPSESYLPSPEKLKRMIIVK
GKKLPSDPDVLEGEVTDEDEEAEMSRRMSVDYNGEQKQIRLCRELSDLVSICKSVQYRDF
ELSMKSQNYWEMCSFSETEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFW
NCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGILPGVSP
LALHIKIISGQNFPKPKGACAKGDVIDPYVCIEIHGIPADCSEQRTKTVQQNSDNPIFDE
TFEFQVNLPELAMIRFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVT
LFVHIAITNRSGGGKAQKRSLSVRMGKKVREYTMLRNIGLKTIDDIFKIAVHPLREAIDM
RENMQNAIVSIKELCGLPPIASLKQCLLTLSSRLITSDNTPSVSLVMKDSFPYLEPLGAI
PDVQKKMLTAYDLMIQESRFLIEMADTVQEKIVQCQKAGMEFHEELHNLGAKEGLKGRKL
NKATESFAWNITVLKGQGDLLKNAKNEAIENMKQIQLACLSCGLSKAPSSSAEAKSKRSL
EAIEEKESSEENGKL
Number of residues
1095
Molecular Weight
122726.98
Theoretical pI
5.26
GO Classification
Functions
inositol 1,4,5 trisphosphate binding / phosphatidylinositol phospholipase C activity / phospholipase C activity / signal transducer activity
Processes
gamma-aminobutyric acid signaling pathway / intracellular signal transduction / lipid metabolic process / positive regulation of receptor binding / regulation of peptidyl-serine phosphorylation / regulation of synaptic transmission, GABAergic
Components
cytoplasm / plasma membrane
General Function
Signal transducer activity
Specific Function
Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as a inhibitor of PPP1C.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0010758|Inactive phospholipase C-like protein 1 (PLCL1)
ATGGCCGAGGGCGCGGCCGGCAGGGAGGATCCGGCGCCGCCCGACGCGGCGGGGGGCGAA
GACGACCCCCGAGTGGGCCCGGATGCCGCCGGGGACTGCGTGACGGCGGCCTCTGGGGGC
CGGATGAGGGACCGTCGCAGCGGGGTCGCACTGCCAGGCGCCGCGGGGACCCCAGCGGAC
AGCGAGGCGGGCCTCCTGGAGGCAGCACGGGCGACCCCCCGGCGCAGCAGCATCATCAAG
GATCCTTCAAACCAAAAATGTGGTGGAAGAAAGAAAACCGTGTCTTTCAGCAGCATGCCA
TCGGAAAAGAAAATTAGCAGTGCAAATGACTGCATCAGCTTCATGCAAGCTGGCTGTGAG
TTGAAGAAAGTCCGGCCAAATTCTCGCATTTACAACCGTTTTTTCACTCTGGACACAGAC
CTTCAAGCTCTTCGCTGGGAACCTTCAAAGAAAGACCTCGAGAAAGCCAAGCTTGATATT
TCTGCCATAAAAGAGATCAGACTGGGGAAAAACACGGAAACATTTAGAAACAATGGCCTT
GCTGACCAGATCTGTGAGGACTGTGCCTTTTCCATACTCCACGGGGAAAACTATGAGTCT
CTGGACCTAGTTGCCAATTCAGCAGATGTGGCAAACATCTGGGTGTCTGGGTTACGGTAC
CTGGTTTCTCGAAGTAAGCAGCCTCTTGATTTTATGGAGGGCAACCAGAACACACCACGG
TTCATGTGGTTGAAAACAGTGTTTGAAGCAGCAGATGTTGATGGGAATGGGATTATGTTG
GAAGACACCTCTGTAGAGTTAATAAAACAACTCAACCCTACTCTGAAGGAAGCCAAGATC
AGGTTAAAGTTTAAAGAAATCCAGAAGAGCAAGGAAAAACTAACCACCCGCGTGACCGAA
GAGGAATTTTGTGAAGCTTTTTGTGAACTTTGCACCAGGCCAGAAGTGTATTTCTTACTT
GTACAGATATCTAAAAACAAAGAATATTTGGATGCCAATGATCTCATGCTCTTTTTAGAA
GCTGAGCAAGGAGTCACCCATATCACCGAGGATATATGCTTAGACATCATAAGGAGATAC
GAACTTTCTGAAGAGGGACGTCAAAAAGGGTTTCTTGCAATTGATGGCTTTACCCAGTAT
TTATTGTCATCAGAATGTGACATTTTTGATCCTGAGCAAAAGAAGGTTGCCCAAGATATG
ACCCAGCCATTATCTCACTACTATATCAATGCCTCTCATAACACCTATCTAATAGAAGAC
CAGTTCAGGGGGCCAGCTGACATCAATGGGTACATTAGAGCTTTGAAAATGGGCTGTCGA
AGCGTTGAACTCGATGTAAGTGATGGTTCAGATAATGAACCAATCCTTTGTAATCGAAAT
AACATGACAACCCATGTTTCCTTTCGAAGTGTCATAGAGGTAATAAATAAATTTGCCTTT
GTTGCTTCTGAATACCCACTCATTCTTTGCTTGGGAAATCACTGCTCCTTGCCGCAGCAG
AAGGTAATGGCTCAACAGATGAAAAAGGTCTTTGGCAATAAACTCTATACTGAAGCACCT
TTGCCCTCAGAATCCTACCTCCCATCACCAGAAAAATTAAAAAGAATGATCATTGTGAAA
GGAAAGAAGTTGCCTTCTGATCCAGATGTGTTAGAAGGAGAAGTAACAGATGAAGATGAA
GAAGCTGAAATGTCTCGAAGGATGTCGGTAGATTACAATGGTGAGCAGAAGCAAATCCGA
CTCTGTAGGGAGCTCTCTGATTTGGTGTCTATTTGTAAATCTGTTCAATACAGGGATTTT
GAACTATCTATGAAAAGCCAAAACTATTGGGAAATGTGTTCATTTAGTGAAACAGAGGCC
AGCCGCATTGCAAATGAGTACCCAGAGGATTTTGTTAATTATAATAAGAAGTTCTTATCA
AGAATCTATCCAAGTGCCATGAGGATCGATTCCAGTAACTTGAATCCACAGGACTTTTGG
AATTGTGGCTGTCAGATTGTAGCAATGAATTTTCAGACTCCGGGTCCAATGATGGACCTT
CACACGGGCTGGTTTCTTCAAAACGGGGGATGTGGTTATGTTCTAAGGCCGTCTATAATG
CGAGATGAAGTTTCTTACTTCAGCGCAAATACAAAGGGCATTCTACCTGGGGTGTCTCCT
CTAGCTCTTCATATCAAGATCATCAGTGGTCAGAATTTCCCAAAGCCCAAGGGAGCTTGT
GCCAAAGGGGATGTCATAGATCCCTATGTTTGTATAGAGATACACGGAATTCCAGCGGAT
TGTTCGGAACAAAGAACTAAAACTGTACAGCAAAACAGTGATAATCCTATTTTTGATGAA
ACTTTTGAGTTCCAAGTAAACCTACCTGAGCTGGCCATGATCCGTTTTGTTGTTCTGGAT
GATGACTACATTGGGGATGAGTTTATAGGGCAATATACGATACCATTTGAATGTTTGCAG
CCTGGATATCGGCATGTTCCCCTGCGTTCTTTTGTGGGTGACATCATGGAGCACGTAACC
CTTTTTGTCCACATAGCAATAACTAATCGAAGTGGAGGAGGAAAGGCACAGAAGCGCAGT
CTTTCAGTGAGAATGGGGAAGAAAGTTCGGGAATATACCATGCTCAGGAATATCGGTCTT
AAAACCATTGATGACATCTTTAAAATAGCGGTTCATCCATTACGAGAAGCCATAGATATG
AGAGAAAATATGCAGAATGCAATCGTGTCTATTAAGGAACTATGTGGACTCCCTCCAATT
GCCAGTCTGAAGCAGTGCCTGTTAACTCTGTCATCTCGGCTCATCACCAGTGACAATACT
CCTTCAGTCTCACTTGTGATGAAAGACAGCTTTCCTTACCTGGAGCCTCTGGGTGCAATT
CCAGATGTGCAGAAAAAGATGCTGACTGCTTATGATCTGATGATTCAAGAGAGCCGGTTT
CTCATAGAAATGGCGGACACAGTCCAGGAAAAGATTGTACAGTGTCAGAAAGCAGGGATG
GAGTTCCATGAAGAACTTCATAATTTGGGGGCAAAAGAAGGCTTGAAGGGAAGAAAACTC
AACAAAGCAACTGAGAGCTTTGCTTGGAACATTACAGTATTGAAGGGCCAAGGAGATCTG
TTGAAGAATGCCAAGAATGAAGCTATAGAAAACATGAAGCAGATCCAGCTGGCATGCCTG
TCCTGTGGACTGAGTAAAGCCCCCAGCAGCAGTGCTGAGGCCAAGAGCAAGCGCAGCCTG
GAAGCCATAGAGGAGAAGGAAAGTAGTGAGGAGAATGGGAAGCTGTGA
Chromosome Location
2
Locus
2q33
External Identifiers
ResourceLink
UniProtKB IDQ15111
UniProtKB Entry NamePLCL1_HUMAN
GenBank Protein ID780122
GenBank Gene IDD42108
GenAtlas IDPLCL1
HGNC IDHGNC:9063
General References
  1. Kohno T, Otsuka T, Takano H, Yamamoto T, Hamaguchi M, Terada M, Yokota J: Identification of a novel phospholipase C family gene at chromosome 2q33 that is homozygously deleted in human small cell lung carcinoma. Hum Mol Genet. 1995 Apr;4(4):667-74. [Article]
  2. Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 2005 Apr 7;434(7034):724-31. [Article]
  3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  4. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [Article]
  5. Yoshimura K, Takeuchi H, Sato O, Hidaka K, Doira N, Terunuma M, Harada K, Ogawa Y, Ito Y, Kanematsu T, Hirata M: Interaction of p130 with, and consequent inhibition of, the catalytic subunit of protein phosphatase 1alpha. J Biol Chem. 2001 May 25;276(21):17908-13. Epub 2001 Mar 2. [Article]
  6. Kanematsu T, Jang IS, Yamaguchi T, Nagahama H, Yoshimura K, Hidaka K, Matsuda M, Takeuchi H, Misumi Y, Nakayama K, Yamamoto T, Akaike N, Hirata M, Nakayama K: Role of the PLC-related, catalytically inactive protein p130 in GABA(A) receptor function. EMBO J. 2002 Mar 1;21(5):1004-11. [Article]
  7. Kanematsu T, Takeuchi H, Terunuma M, Hirata M: PRIP, a novel Ins(1,4,5)P3 binding protein, functional significance in Ca2+ signaling and extension to neuroscience and beyond. Mol Cells. 2005 Dec 31;20(3):305-14. [Article]
  8. Yanagihori S, Terunuma M, Koyano K, Kanematsu T, Ho Ryu S, Hirata M: Protein phosphatase regulation by PRIP, a PLC-related catalytically inactive protein--implications in the phospho-modulation of the GABAA receptor. Adv Enzyme Regul. 2006;46:203-22. Epub 2006 Jul 18. [Article]
  9. Murakami A, Matsuda M, Nakasima A, Hirata M: Characterization of the human PRIP-1 gene structure and transcriptional regulation. Gene. 2006 Nov 1;382:129-39. Epub 2006 Jul 20. [Article]
  10. Kanematsu T, Yasunaga A, Mizoguchi Y, Kuratani A, Kittler JT, Jovanovic JN, Takenaka K, Nakayama KI, Fukami K, Takenawa T, Moss SJ, Nabekura J, Hirata M: Modulation of GABA(A) receptor phosphorylation and membrane trafficking by phospholipase C-related inactive protein/protein phosphatase 1 and 2A signaling complex underlying brain-derived neurotrophic factor-dependent regulation of GABAergic inhibition. J Biol Chem. 2006 Aug 4;281(31):22180-9. Epub 2006 Jun 5. [Article]
  11. Kanematsu T, Fujii M, Mizokami A, Kittler JT, Nabekura J, Moss SJ, Hirata M: Phospholipase C-related inactive protein is implicated in the constitutive internalization of GABAA receptors mediated by clathrin and AP2 adaptor complex. J Neurochem. 2007 May;101(4):898-905. Epub 2007 Jan 24. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01103QuinacrineinvestigationalyesinhibitorDetails