Serum paraoxonase/lactonase 3
Details
- Name
- Serum paraoxonase/lactonase 3
- Synonyms
- 3.1.1.2
- Gene Name
- PON3
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0017139|Serum paraoxonase/lactonase 3 MGKLVALVLLGVGLSLVGEMFLAFRERVNASREVEPVEPENCHLIEELESGSEDIDILPS GLAFISSGLKYPGMPNFAPDEPGKIFLMDLNEQNPRAQALEISGGFDKELFNPHGISIFI DKDNTVYLYVVNHPHMKSTVEIFKFEEQQRSLVYLKTIKHELLKSVNDIVVLGPEQFYAT RDHYFTNSLLSFFEMILDLRWTYVLFYSPREVKVVAKGFCSANGITVSADQKYVYVADVA AKNIHIMEKHDNWDLTQLKVIQLGTLVDNLTVDPATGDILAGCHPNPMKLLNYNPEDPPG SEVLRIQNVLSEKPRVSTVYANNGSVLQGTSVASVYHGKILIGTVFHKTLYCEL
- Number of residues
- 354
- Molecular Weight
- 39607.185
- Theoretical pI
- 5.1
- GO Classification
- Functions3,4-dihydrocoumarin hydrolase activity / aryldialkylphosphatase activity / arylesterase activity / dihydrocoumarin hydrolase activity / metal ion binding / protein homodimerization activityProcessesaromatic compound catabolic process / carboxylic acid catabolic process / coumarin catabolic process / negative regulation of superoxide anion generation / phenylacetate catabolic process / response to external stimulus / response to toxic substanceComponentsextracellular exosome / extracellular space / intracellular membrane-bounded organelle
- General Function
- Protein homodimerization activity
- Specific Function
- Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents.
- Pfam Domain Function
- Arylesterase (PF01731)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0017140|Serum paraoxonase/lactonase 3 (PON3) ATGGGGAAGCTCGTGGCGCTGGTCCTGCTGGGGGTCGGCCTGTCCTTAGTCGGGGAGATG TTCCTGGCGTTTAGAGAAAGGGTGAATGCCTCTCGAGAAGTGGAGCCAGTAGAACCTGAA AACTGCCACCTTATTGAGGAACTTGAAAGTGGCTCTGAAGATATTGATATACTTCCTAGT GGGCTGGCTTTTATCTCCAGTGGATTAAAATATCCAGGCATGCCAAACTTTGCGCCAGAT GAACCAGGAAAAATCTTCTTGATGGATCTGAATGAACAAAACCCAAGGGCACAAGCGCTA GAAATCAGTGGTGGATTTGACAAAGAATTATTTAATCCACATGGGATCAGTATTTTCATC GACAAAGACAATACTGTGTATCTTTATGTTGTGAATCATCCCCACATGAAGTCCACTGTG GAGATATTTAAATTTGAGGAACAACAACGTTCTCTGGTATACCTGAAAACTATAAAACAT GAACTTCTCAAAAGTGTGAATGACATTGTGGTTCTTGGACCAGAACAGTTCTATGCCACC AGAGACCACTATTTTACCAACTCCCTCCTGTCATTTTTTGAGATGATCTTGGATCTTCGC TGGACTTATGTTCTTTTCTACAGCCCAAGGGAGGTTAAAGTGGTGGCCAAAGGATTTTGT AGTGCCAATGGGATCACAGTCTCAGCAGACCAGAAGTATGTCTATGTAGCTGATGTAGCA GCTAAGAACATTCACATAATGGAAAAACATGATAACTGGGATTTAACTCAACTGAAGGTG ATACAGTTGGGCACCTTAGTGGATAACCTGACTGTCGATCCTGCCACAGGAGACATTTTG GCAGGATGCCATCCTAATCCTATGAAGCTACTGAACTATAACCCTGAGGACCCTCCAGGA TCAGAAGTACTTCGCATCCAGAATGTTTTGTCTGAGAAGCCCAGGGTGAGCACCGTGTAT GCCAACAATGGCTCTGTGCTTCAGGGCACCTCTGTGGCTTCTGTGTACCATGGGAAAATT CTCATAGGCACCGTATTTCACAAAACTCTGTACTGTGAGCTCTAG
- Chromosome Location
- 7
- Locus
- 7q21.3
- External Identifiers
Resource Link UniProtKB ID Q15166 UniProtKB Entry Name PON3_HUMAN GenBank Protein ID 12751374 GenBank Gene ID AF320003 HGNC ID HGNC:9206 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00227 Lovastatin approved, investigational unknown substrate Details DB00974 Edetic acid approved, vet_approved unknown inhibitor Details DB14600 Edetate disodium anhydrous approved, vet_approved unknown inhibitor Details DB14598 Edetate calcium disodium anhydrous approved unknown inhibitor Details