Prostaglandin E synthase 3

Details

Name
Prostaglandin E synthase 3
Synonyms
  • 5.3.99.3
  • cPGES
  • Cytosolic prostaglandin E2 synthase
  • Hsp90 co-chaperone
  • P23
  • Progesterone receptor complex p23
  • TEBP
  • Telomerase-binding protein p23
Gene Name
PTGES3
Organism
Humans
Amino acid sequence
>lcl|BSEQ0004870|Prostaglandin E synthase 3
MQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLFHCID
PNDSKHKRTDRSILCCLRKGESGQSWPRLTKERAKLNWLSVDFNNWKDWEDDSDEDMSNF
DRFSEMMNNMGGDEDVDLPEVDGADDDSQDSDDEKMPDLE
Number of residues
160
Molecular Weight
18697.195
Theoretical pI
4.11
GO Classification
Functions
prostaglandin-E synthase activity / telomerase activity / unfolded protein binding
Processes
arachidonic acid metabolic process / cellular response to heat / chaperone cofactor-dependent protein refolding / cyclooxygenase pathway / prostaglandin biosynthetic process / regulation of cellular response to heat / RNA-dependent DNA replication / signal transduction / small molecule metabolic process / telomere maintenance
Components
chromosome, telomeric region / cytoplasm / cytosol / extracellular exosome / nucleoplasm / nucleus / telomerase holoenzyme complex
General Function
Unfolded protein binding
Specific Function
Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0021328|Prostaglandin E synthase 3 (PTGES3)
ATGCAGCCTGCTTCTGCAAAGTGGTACGATCGAAGGGACTATGTCTTCATTGAATTTTGT
GTTGAAGACAGTAAGGATGTTAATGTAAATTTTGAAAAATCCAAACTTACATTCAGTTGT
CTCGGAGGAAGTGATAATTTTAAGCATTTAAATGAAATTGATCTTTTTCACTGTATTGAT
CCAAATGATTCCAAGCATAAAAGAACGGACAGATCAATTTTATGTTGTTTACGAAAAGGA
GAATCTGGCCAGTCATGGCCAAGGTTAACAAAAGAAAGGGCAAAGCTTAATTGGCTTAGT
GTCGACTTCAATAATTGGAAAGACTGGGAAGATGATTCAGATGAAGACATGTCTAATTTT
GATCGTTTCTCTGAGGATTCACAAGACAGTGATGATGAAAAAATGCCAGATCTGGAGTAA
Chromosome Location
12
Locus
12q13.3|12
External Identifiers
ResourceLink
UniProtKB IDQ15185
UniProtKB Entry NameTEBP_HUMAN
GenBank Gene IDL24804
GenAtlas IDPTGES3
HGNC IDHGNC:16049
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB05036Grn163linvestigationalunknownDetails
DB00316AcetaminophenapprovedunknowninhibitorDetails
DB09130Copperapproved, investigationalunknownDetails