Dual specificity testis-specific protein kinase 1
Details
- Name
- Dual specificity testis-specific protein kinase 1
- Synonyms
- 2.7.12.1
- Testicular protein kinase 1
- Gene Name
- TESK1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0051668|Dual specificity testis-specific protein kinase 1 MAGERPPLRGPGPGPGEVPGEGPPGPGGTGGGPGRGRPSSYRALRSAVSSLARVDDFHCA EKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRGNTLREVQLMNRLRHPNILRFMGVCV HQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHLALDIARGLRYLHSKGVFHRDLTSKN CLVRREDRGFTAVVGDFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKADV FAFGIVLCELIARVPADPDYLPRTEDFGLDVPAFRTLVGDDCPLPFLLLAIHCCNLEPST RAPFTEITQHLEWILEQLPEPAPLTRTALTHNQGSVARGGPSATLPRPDPRLSRSRSDLF LPPSPESPPNWGDNLTRVNPFSLREDLRGGKIKLLDTPSKPVLPLVPPSPFPSTQLPLVT TPETLVQPGTPARRCRSLPSSPELPRRMETALPGPGPPAVGPSAEEKMECEGSSPEPEPP GPAPQLPLAVATDNFISTCSSASQPWSPRSGPVLNNNPPAVVVNSPQGWAGEPWNRAQHS LPRAAALERTEPSPPPSAPREPDEGLPCPGCCLGPFSFGFLSMCPRPTPAVARYRNLNCE AGSLLCHRGHHAKPPTPSLQLPGARS
- Number of residues
- 626
- Molecular Weight
- 67683.685
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / metal ion binding / protein C-terminus binding / protein kinase binding / protein serine/threonine kinase activity / protein serine/threonine/tyrosine kinase activity / protein tyrosine kinase activity / signal transducer activityProcessesintracellular signal transduction / negative regulation of protein autophosphorylation / negative regulation of protein serine/threonine kinase activity / positive regulation of stress fiber assembly / regulation of protein localization / spermatogenesisComponentscytoplasm / cytoplasmic vesicle / cytosol
- General Function
- Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity).
- Specific Function
- Atp binding
- Pfam Domain Function
- PK_Tyr_Ser-Thr (PF07714)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0051669|Dual specificity testis-specific protein kinase 1 (TESK1) ATGGCCGGGGAACGGCCCCCACTGCGGGGCCCTGGGCCCGGGCCTGGAGAGGTGCCGGGG GAGGGGCCCCCGGGGCCGGGGGGCACGGGCGGAGGCCCGGGCCGGGGCCGCCCCTCCTCC TACCGGGCTCTCCGCAGCGCCGTGTCTAGCCTGGCGCGTGTGGACGATTTTCACTGCGCG GAGAAGATCGGGGCCGGCTTCTTCTCTGAGGTCTACAAGGTTCGGCACCGACAGTCAGGG CAAGTCATGGTGCTGAAGATGAACAAGCTCCCCAGTAACCGGGGCAACACACTACGGGAA GTGCAGCTGATGAACCGGCTCAGGCACCCCAACATCCTAAGGTTCATGGGAGTCTGTGTG CACCAGGGACAGCTGCACGCTCTTACAGAGTATATGAATGGGGGGACATTGGAACAGCTG CTCAGCTCCCCTGAACCCCTGTCCTGGCCGGTCAGGCTCCACCTGGCCCTGGACATTGCC CGAGGCCTGCGGTACCTGCACTCCAAAGGTGTATTTCACCGCGACCTCACATCCAAGAAC TGTCTAGTCCGACGGGAAGATCGAGGCTTCACCGCTGTCGTGGGTGACTTCGGGCTGGCC GAAAAGATTCCTGTGTATAGGGAGGGGGCAAGGAAGGAGCCATTGGCCGTGGTGGGCTCC CCATACTGGATGGCTCCAGAGGTGTTACGGGGTGAGCTGTATGATGAGAAGGCTGATGTC TTTGCCTTCGGGATTGTCCTCTGTGAGCTCATCGCCCGAGTACCTGCAGACCCTGACTAC CTACCACGCACTGAGGACTTTGGCCTGGATGTGCCTGCTTTCCGAACTCTGGTGGGGGAT GACTGCCCACTGCCTTTCTTGCTCCTGGCCATCCACTGCTGCAACCTGGAACCCAGCACC CGTGCCCCCTTCACCGAAATTACCCAGCACCTGGAATGGATCCTGGAGCAGCTGCCTGAG CCAGCCCCACTCACCAGGACCGCCCTGACACACAATCAGGGCTCTGTTGCAAGAGGGGGT CCCTCTGCCACGCTTCCCAGGCCAGATCCCCGGCTTTCCCGAAGCCGGTCAGACCTCTTC CTGCCCCCATCACCAGAATCACCCCCCAACTGGGGGGACAATCTGACTCGAGTCAACCCC TTCTCACTACGGGAAGACCTCAGGGGTGGCAAGATCAAGCTCTTAGACACACCCAGCAAG CCAGTCCTGCCTCTTGTGCCACCATCACCATTCCCATCCACTCAGCTGCCCTTGGTGACC ACTCCGGAGACCCTGGTCCAGCCTGGGACACCTGCCCGCCGCTGCCGCTCACTACCCTCA TCCCCCGAGCTCCCCCGCCGTATGGAGACAGCACTGCCAGGTCCTGGCCCTCCCGCTGTG GGCCCCTCGGCTGAAGAGAAGATGGAGTGCGAGGGCAGCAGCCCTGAGCCGGAACCTCCA GGGCCAGCGCCCCAGCTGCCTCTGGCTGTGGCCACAGACAACTTCATCAGCACCTGTTCC TCGGCCTCCCAACCCTGGTCCCCTAGATCAGGACCCGTCCTCAATAACAATCCCCCAGCT GTGGTGGTGAACTCCCCACAAGGCTGGGCTGGGGAGCCCTGGAACCGGGCCCAGCATAGC CTGCCCCGGGCGGCAGCCCTGGAGCGGACAGAACCCTCGCCACCCCCTTCAGCTCCCCGG GAGCCCGATGAGGGGCTGCCCTGTCCTGGCTGCTGCCTCGGCCCCTTCAGCTTTGGCTTC CTGTCCATGTGCCCCCGCCCCACACCAGCTGTTGCCCGCTACCGCAACCTGAACTGTGAG GCGGGCAGTCTCCTCTGCCACCGAGGGCACCACGCCAAGCCACCCACACCCAGCCTGCAG CTGCCTGGGGCACGCTCTTAG
- Chromosome Location
- 9
- Locus
- 9p13.3
- External Identifiers
Resource Link UniProtKB ID Q15569 UniProtKB Entry Name TESK1_HUMAN HGNC ID HGNC:11731 - General References
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