Splicing factor 1
Details
- Name
- Splicing factor 1
- Synonyms
- BBP
- Mammalian branch point-binding protein
- mBBP
- Transcription factor ZFM1
- ZFM1
- Zinc finger gene in MEN1 locus
- Zinc finger protein 162
- ZNF162
- Gene Name
- SF1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0049944|Splicing factor 1 MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIVQLQIED LTRKLRTGDLGIPPNPEDRSPSPEPIYNSEGKRLNTREFRTRKKLEEERHNLITEMVALN PDFKPPADYKPPATRVSDKVMIPQDEYPEINFVGLLIGPRGNTLKNIEKECNAKIMIRGK GSVKEGKVGRKDGQMLPGEDEPLHALVTANTMENVKKAVEQIRNILKQGIETPEDQNDLR KMQLRELARLNGTLREDDNRILRPWQSSETRSITNTTVCTKCGGAGHIASDCKFQRPGDP QSAQDKARMDKEYLSLMAELGEAPVPASVGSTSGPATTPLASAPRPAAPANNPPPPSLMS TTQSRPPWMNSGPSESRPYHGMHGGGPGGPGGGPHSFPHPLPSLTGGHGGHPMQHNPNGP PPPWMQPPPPPMNQGPHPPGHHGPPPMDQYLGSTPVGSGVYRLHQGKGMMPPPPMGMMPP PPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLPWQQNTTTTTTSAGTGS IPPWQQQQAAAAASPGAPQMQGNPTMVPLPPGVQPPLPPGAPPPPPPPPPGSAGMMYAPP PPPPPPMDPSNFVTMMGMGVAGMPPFGMPPAPPPPPPQN
- Number of residues
- 639
- Molecular Weight
- 68329.55
- Theoretical pI
- Not Available
- GO Classification
- Functionsidentical protein binding / pre-mRNA branch point binding / RNA binding / transcription corepressor activity / zinc ion bindingProcessesLeydig cell differentiation / male sex determination / mRNA 3'-splice site recognition / mRNA splicing, via spliceosome / negative regulation of smooth muscle cell proliferation / nuclear body organization / regulation of steroid biosynthetic process / regulation of transcription, DNA-templated / spliceosomal complex assembly / transcription, DNA-templatedComponentsnuclear body / nucleoplasm / nucleus / ribosome / spliceosomal complex
- General Function
- Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor.
- Specific Function
- Identical protein binding
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0049945|Splicing factor 1 (SF1) ATGGCGACCGGAGCGAACGCCACGCCGTTGGACTTCCCAAGTAAGAAGCGGAAGAGGAGC CGCTGGAACCAAGACACAATGGAACAGAAGACAGTGATTCCAGGAATGCCTACAGTTATT CCCCCTGGACTTACTCGAGAACAAGAAAGAGCTTATATAGTGCAACTGCAGATAGAAGAC CTGACTCGTAAACTGCGCACAGGAGACCTGGGCATCCCCCCTAACCCTGAGGACAGGTCC CCTTCCCCTGAGCCCATCTACAATAGCGAGGGGAAGCGGCTTAACACCCGAGAGTTCCGC ACCCGCAAAAAGCTGGAAGAGGAGCGGCACAACCTCATCACAGAGATGGTTGCACTCAAT CCGGATTTCAAGCCACCTGCAGATTACAAACCTCCAGCAACACGTGTGAGTGATAAAGTC ATGATTCCACAAGATGAGTACCCAGAAATCAACTTTGTGGGGCTGCTCATCGGGCCCAGA GGGAACACCCTGAAGAACATAGAGAAGGAGTGCAATGCCAAGATTATGATCCGGGGGAAA GGGTCTGTGAAAGAAGGGAAGGTTGGGCGCAAAGATGGCCAGATGTTGCCAGGAGAAGAT GAGCCACTTCATGCCCTGGTTACTGCCAATACAATGGAGAACGTCAAAAAGGCAGTGGAA CAGATAAGAAACATCCTGAAGCAGGGTATCGAGACTCCAGAGGACCAGAATGATCTACGG AAGATGCAGCTTCGGGAGTTGGCTCGCTTAAATGGGACCCTTCGGGAAGACGATAACAGG ATCTTAAGACCCTGGCAGAGCTCAGAGACCCGCAGCATTACCAACACCACAGTGTGTACC AAGTGTGGAGGGGCTGGCCACATTGCTTCAGACTGTAAATTCCAAAGGCCTGGTGATCCT CAGTCAGCTCAGGATAAAGCACGGATGGATAAAGAATATTTGTCCCTCATGGCTGAACTG GGTGAAGCACCTGTCCCAGCATCTGTGGGCTCCACCTCTGGGCCTGCCACCACACCCCTG GCCAGCGCACCTCGTCCTGCTGCTCCCGCCAACAACCCACCTCCACCGTCTCTCATGTCT ACCACCCAGAGCCGCCCACCCTGGATGAATTCTGGCCCTTCAGAGAGTCGGCCCTACCAC GGCATGCATGGAGGTGGTCCTGGTGGGCCCGGAGGTGGCCCCCACAGCTTCCCACACCCA TTACCCAGCCTGACAGGTGGGCATGGTGGACATCCCATGCAGCACAACCCCAATGGACCC CCACCCCCTTGGATGCAGCCACCACCACCACCGATGAACCAGGGCCCCCACCCTCCTGGG CACCATGGCCCTCCTCCAATGGATCAGTACCTGGGAAGTACGCCTGTGGGCTCTGGGGTC TATCGCCTGCATCAAGGAAAAGGTATGATGCCGCCACCACCTATGGGCATGATGCCGCCG CCGCCGCCGCCTCCCAGTGGGCAGCCCCCACCCCCTCCCTCTGGTCCTCTTCCCCCATGG CAACAACAGCAGCAGCAGCCTCCGCCACCCCCTCCGCCCAGCAGCAGTATGGCTTCCAGT ACCCCCTTGCCATGGCAGCAAAATACGACGACTACCACCACGAGCGCTGGCACAGGGTCC ATCCCGCCATGGCAACAGCAGCAGGCGGCTGCCGCAGCTTCTCCAGGAGCCCCTCAGATG CAAGGCAACCCCACTATGGTGCCCCTGCCCCCCGGGGTCCAGCCGCCTCTGCCGCCTGGG GCCCCTCCCCCTCCGCCGCCTCCACCGCCTGGTTCCGCCGGCATGATGTATGCCCCGCCC CCTCCTCCTCCGCCTCCCATGGACCCTTCTAACTTTGTCACCATGATGGGCATGGGGGTG GCGGGCATGCCGCCCTTCGGGATGCCTCCAGCTCCCCCACCGCCTCCACCACAGAACTAG
- Chromosome Location
- 11
- Locus
- 11q13.1
- External Identifiers
Resource Link UniProtKB ID Q15637 UniProtKB Entry Name SF01_HUMAN HGNC ID HGNC:12950 - General References
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