Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial

Details

Name

Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial

Synonyms

• 1.5.5.1
• Electron-transferring-flavoprotein dehydrogenase
• ETF dehydrogenase
• ETF-QO

Gene Name

ETFDH

Organism

Humans

Amino acid sequence

>lcl|BSEQ0037265|Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial
MLVPLAKLSCLAYQCFHALKIKKNYLPLCATRWSSTSTVPRITTHYTIYPRDKDKRWEGV
NMERFAEEADVVIVGAGPAGLSAAVRLKQLAVAHEKDIRVCLVEKAAQIGAHTLSGACLD
PGAFKELFPDWKEKGAPLNTPVTEDRFGILTEKYRIPVPILPGLPMNNHGNYIVRLGHLV
SWMGEQAEALGVEVYPGYAAAEVLFHDDGSVKGIATNDVGIQKDGAPKATFERGLELHAK
VTIFAEGCHGHLAKQLYKKFDLRANCEPQTYGIGLKELWVIDEKNWKPGRVDHTVGWPLD
RHTYGGSFLYHLNEGEPLVALGLVVGLDYQNPYLSPFREFQRWKHHPSIRPTLEGGKRIA
YGARALNEGGFQSIPKLTFPGGLLIGCSPGFMNVPKIKGTHTAMKSGILAAESIFNQLTS
ENLQSKTIGLHVTEYEDNLKNSWVWKELYSVRNIRPSCHGVLGVYGGMIYTGIFYWILRG
MEPWTLKHKGSDFERLKPAKDCTPIEYPKPDGQISFDLLSSVALSGTNHEHDQPAHLTLR
DDSIPVNRNLSIYDGPEQRFCPAGVYEFVPVEQGDGFRLQINAQNCVHCKTCDIKDPSQN
INWVVPEGGGGPAYNGM

Number of residues

617

Molecular Weight

68494.96

Theoretical pI

7.59

GO Classification

Functions

4 iron, 4 sulfur cluster binding / electron carrier activity / electron-transferring-flavoprotein dehydrogenase activity / flavin adenine dinucleotide binding / metal ion binding / oxidoreductase activity / oxidoreductase activity, oxidizing metal ions with flavin as acceptor / quinone binding / ubiquinone binding

Processes

cellular metabolic process / electron transport chain / fatty acid beta-oxidation using acyl-CoA dehydrogenase / respiratory electron transport chain / response to oxidative stress / small molecule metabolic process

Components

integral component of mitochondrial inner membrane / mitochondrial matrix / mitochondrial membrane

General Function

Ubiquinone binding

Specific Function

Accepts electrons from ETF and reduces ubiquinone.

Pfam Domain Function

• ETF_QO (PF05187)

Transmembrane Regions

Not Available

Cellular Location

Mitochondrion inner membrane

Gene sequence

>lcl|BSEQ0019489|Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (ETFDH)
ATGCTGGTGCCGCTAGCCAAGCTGTCCTGCCTGGGAGTGAACATGGAAAGGTTTGCAGAA
GAAGCAGATGTTGTAATAGTTGGTGCAGGCCCTGCAGGGCTCTCTGCAGCTGTTCGTCTA
AAACAGTTGGCTGTGGCACATGAAAAGGACATCCGTGTGTGTCTAGTGGAGAAAGCTGCC
CAGATAGGAGCTCATACTCTCTCAGGGGCTTGCCTTGATCCAGGTGCTTTTAAAGAACTC
TTCCCAGACTGGAAAGAGAAGGGGGCTCCACTTAACACTCCTGTAACAGAAGACAGATTT
GGAATTTTAACAGAGAAATACAGAATTCCTGTGCCAATTCTTCCAGGGCTTCCAATGAAT
AATCATGGCAATTACATTGTACGCTTGGGACATTTAGTGAGCTGGATGGGCGAACAAGCA
GAAGCCCTTGGTGTTGAAGTATACCCTGGTTATGCAGCTGCTGAGGTCCTTTTTCATGAT
GATGGTAGTGTAAAAGGAATTGCCACTAACGATGTAGGGATACAAAAGGATGGTGCACCA
AAGGCAACATTTGAGAGAGGACTGGAACTACATGCTAAAGTCACAATTTTTGCAGAAGGT
TGCCATGGACATCTAGCCAAGCAACTATATAAGAAGTTTGATTTGAGAGCAAATTGTGAA
CCTCAAACCTACGGGATTGGACTGAAGGAGTTATGGGTTATTGATGAAAAGAACTGGAAA
CCTGGGAGAGTAGATCACACTGTTGGTTGGCCCTTGGACAGACATACCTATGGAGGATCT
TTCCTCTATCATTTGAATGAAGGTGAACCCCTAGTAGCTCTTGGTCTTGTGGTTGGTCTA
GACTATCAGAATCCATACCTGAGTCCATTTAGAGAGTTCCAAAGGTGGAAACACCATCCT
AGCATTCGGCCAACCTTGGAAGGTGGAAAAAGGATTGCATACGGAGCCAGAGCTCTCAAT
GAAGGTGGCTTTCAGTCTATACCAAAACTCACCTTTCCTGGTGGTTTACTAATTGGTTGT
AGTCCTGGTTTTATGAATGTTCCCAAGATCAAAGGTACTCACACAGCAATGAAAAGTGGA
ATTTTAGCAGCAGAATCTATTTTTAATCAACTAACTAGTGAAAATCTCCAATCAAAGACA
ATAGGACTCCATGTAACTGAATATGAGGACAATTTGAAGAACTCATGGGTATGGAAAGAG
CTATATTCTGTTAGAAATATAAGACCGTCCTGCCACGGAGTACTGGGTGTATATGGAGGG
ATGATTTACACTGGAATCTTTTACTGGATATTGAGAGGAATGGAGCCGTGGACTCTGAAA
CATAAAGGTTCTGACTTTGAACGGCTCAAGCCAGCCAAGGATTGCACACCTATTGAGTAT
CCAAAACCCGATGGACAGATCAGTTTTGACCTCTTGTCATCTGTGGCTCTGAGTGGTACT
AATCATGAACATGACCAGCCGGCACACTTAACCTTAAGGGATGACAGTATACCTGTAAAT
AGAAATCTGTCGATATATGATGGGCCCGAGCAGCGATTCTGTCCTGCAGGAGTTTATGAA
TTTGTACCTGTGGAACAAGGTGATGGATTTCGGTTACAGATAAATGCTCAGAACTGTGTA
CATTGTAAAACATGTGATATTAAAGATCCAAGTCAGAATATTAACTGGGTGGTACCTGAA
GGTGGAGGAGGACCTGCTTACAATGGAATGTAA

Chromosome Location

4

Locus

4q32-q35

External Identifiers

Resource	Link
UniProtKB ID	Q16134
UniProtKB Entry Name	ETFD_HUMAN
GenBank Protein ID	545621
GenBank Gene ID	S69232
HGNC ID	HGNC:3483

General References

1. Goodman SI, Axtell KM, Bindoff LA, Beard SE, Gill RE, Frerman FE: Molecular cloning and expression of a cDNA encoding human electron transfer flavoprotein-ubiquinone oxidoreductase. Eur J Biochem. 1994 Jan 15;219(1-2):277-86. [Article]
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Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB04141	2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol	experimental	unknown		Details
DB00331	Metformin	approved	yes	inhibitor	Details