Deoxyguanosine kinase, mitochondrial
Details
- Name
- Deoxyguanosine kinase, mitochondrial
- Synonyms
- 2.7.1.113
- DGK
- Gene Name
- DGUOK
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0006911|Deoxyguanosine kinase, mitochondrial MAAGRLFLSRLRAPFSSMAKSPLEGVSSSRGLHAGRGPRRLSIEGNIAVGKSTFVKLLTK TYPEWHVATEPVATWQNIQAAGTQKACTAQSLGNLLDMMYREPARWSYTFQTFSFLSRLK VQLEPFPEKLLQARKPVQIFERSVYSDRYIFAKNLFENGSLSDIEWHIYQDWHSFLLWEF ASRITLHGFIYLQASPQVCLKRLYQRAREEEKGIELAYLEQLHGQHEAWLIHKTTKLHFE ALMNIPVLVLDVNDDFSEEVTKQEDLMREVNTFVKNL
- Number of residues
- 277
- Molecular Weight
- 32055.53
- Theoretical pI
- 8.97
- GO Classification
- FunctionsATP binding / deoxyguanosine kinase activity / nucleoside kinase activityProcessesdeoxyribonucleoside monophosphate biosynthetic process / dGTP metabolic process / guanosine metabolic process / negative regulation of neuron projection development / nucleobase-containing small molecule metabolic process / nucleotide biosynthetic process / protein phosphorylation / purine deoxyribonucleoside metabolic process / purine nucleobase metabolic process / purine-containing compound salvage / small molecule metabolic processComponentscytosol / mitochondrial matrix / mitochondrion / nucleus
- General Function
- Nucleoside kinase activity
- Specific Function
- Required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely employed as antiviral and chemotherapeutic agents.
- Pfam Domain Function
- dNK (PF01712)
- Transmembrane Regions
- Not Available
- Cellular Location
- Mitochondrion
- Gene sequence
>lcl|BSEQ0012493|Deoxyguanosine kinase, mitochondrial (DGUOK) ATGGCCGCGGGCCGCCTCTTTCTAAGTCGGCTTCGAGCACCCTTCAGTTCCATGGCCAAG AGCCCACTCGAGGGCGTTTCCTCCTCCAGAGGCCTGCACGCGGGGCGCGGGCCCCGAAGG CTCTCCATCGAAGGCAACATTGCTGTGGGAAAGTCCACGTTTGTGAAGTTACTCACGAAA ACTTACCCAGAATGGCACGTAGCTACAGAACCTGTAGCAACATGGCAGAATATCCAGGCT GCTGGCACCCAAAAAGCCTGCACTGCCCAAAGTCTTGGAAACTTGCTGGATATGATGTAC CGGGAGCCAGCACGATGGTCCTACACATTCCAGACATTTTCCTTTTTGAGCCGCCTGAAA GTACAGCTGGAGCCCTTCCCTGAGAAACTCTTACAGGCCAGGAAGCCAGTACAGATCTTT GAGAGGTCTGTGTACAGTGACAGGTATATCTTTGCAAAGAATCTTTTTGAAAATGGTTCC CTCAGTGACATCGAGTGGCATATCTATCAGGACTGGCATTCTTTTCTCCTGTGGGAGTTT GCCAGCCGGATCACATTACATGGCTTCATCTACCTCCAGGCTTCTCCCCAGGTTTGTTTG AAGAGACTGTACCAGAGGGCCAGGGAGGAGGAGAAAGGAATTGAGCTGGCCTATCTAGAG CAGCTGCATGGCCAACACGAAGCCTGGCTTATTCACAAGACAACGAAGCTCCACTTTGAG GCTCTGATGAACATTCCAGTGCTGGTGTTGGATGTCAATGATGATTTTTCTGAGGAAGTA ACCAAACAAGAAGACCTCATGAGAGAGGTAAACACCTTTGTAAAGAATCTGTAA
- Chromosome Location
- 2
- Locus
- 2p13
- External Identifiers
Resource Link UniProtKB ID Q16854 UniProtKB Entry Name DGUOK_HUMAN GenBank Protein ID 1477482 GenBank Gene ID U41668 HGNC ID HGNC:2858 - General References
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- Wang L, Limongelli A, Vila MR, Carrara F, Zeviani M, Eriksson S: Molecular insight into mitochondrial DNA depletion syndrome in two patients with novel mutations in the deoxyguanosine kinase and thymidine kinase 2 genes. Mol Genet Metab. 2005 Jan;84(1):75-82. [Article]