o-succinylbenzoate synthase

Details

Name
o-succinylbenzoate synthase
Synonyms
  • 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase
  • 4.2.1.113
  • menC
  • o-succinylbenzoic acid synthase
  • OSB synthase
Gene Name
Aaar
Organism
Amycolatopsis sp.
Amino acid sequence
>lcl|BSEQ0011781|o-succinylbenzoate synthase
MKLSGVELRRVQMPLVAPFRTSFGTQSVRELLLLRAVTPAGEGWGECVTMAGPLYSSEYN
DGAEHVLRHYLIPALLAAEDITAAKVTPLLAKFKGHRMAKGALEMAVLDAELRAHERSFA
AELGSVRDSVPCGVSVGIMDTIPQLLDVVGGYLDEGYVRIKLKIEPGWDVEPVRAVRERF
GDDVLLQVDANTAYTLGDAPQLARLDPFGLLLIEQPLEEEDVLGHAELARRIQTPICLDE
SIVSARAAADAIKLGAVQIVNIKPGRVGGYLEARRVHDVCAAHGIPVWCGGMIETGLGRA
ANVALASLPNFTLPGDTSASDRFYKTDITEPFVLSGGHLPVPTGPGLGVAPIPELLDEVT
TAKVWIGS
Number of residues
368
Molecular Weight
39406.005
Theoretical pI
4.93
GO Classification
Functions
hydro-lyase activity / magnesium ion binding
Processes
menaquinone biosynthetic process
General Function
Not Available
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0004897|1107 bp
GTGAAACTCAGCGGTGTGGAACTGCGCCGGGTGCAGATGCCGCTCGTCGCCCCGTTCCGG
ACTTCGTTCGGCACCCAGTCGGTCCGCGAGCTCTTGCTGCTGCGCGCGGTCACGCCGGCC
GGCGAGGGCTGGGGCGAATGCGTGACGATGGCCGGTCCGCTGTACTCGTCGGAGTACAAC
GACGGCGCGGAACACGTGCTGCGGCACTACTTGATCCCGGCGCTGCTGGCCGCGGAAGAC
ATCACCGCGGCGAAGGTGACGCCGCTGCTGGCCAAGTTCAAGGGCCACCGGATGGCCAAG
GGCGCGCTGGAGATGGCCGTGCTCGACGCCGAACTCCGCGCGCACGAGAGGTCGTTCGCC
GCCGAACTCGGATCGGTGCGCGATTCTGTGCCGTGCGGCGTTTCGGTCGGGATCATGGAC
ACCATCCCGCAACTGCTCGACGTCGTGGGCGGATACCTCGACGAGGGTTACGTGCGGATC
AAGCTGAAGATCGAACCCGGCTGGGACGTCGAGCCGGTGCGCGCGGTCCGCGAGCGCTTC
GGCGACGACGTGCTGCTGCAGGTCGACGCGAACACCGCCTACACCCTCGGCGACGCGCCG
CAGCTGGCCCGGCTCGACCCGTTCGGCCTGCTGCTGATCGAGCAGCCGCTGGAAGAGGAG
GACGTGCTCGGCCACGCCGAACTGGCCCGCCGGATCCAGACACCGATCTGCCTCGACGAG
TCGATCGTGTCGGCGCGCGCGGCGGCGGACGCCATCAAGCTGGGCGCGGTCCAAATCGTG
AACATCAAACCGGGCCGCGTCGGCGGGTACCTGGAAGCGCGGCGGGTGCACGACGTGTGC
GCGGCGCACGGGATCCCGGTGTGGTGCGGCGGGATGATCGAGACCGGCCTCGGCCGGGCG
GCGAACGTCGCGCTGGCCTCGCTGCCGAACTTCACCCTGCCCGGCGACACCTCGGCGTCG
GACCGGTTCTACAAAACCGACATCACCGAGCCGTTCGTGCTCTCCGGCGGCCACCTCCCG
GTGCCGACCGGACCGGGCCTCGGCGTGGCGCCGATTCCGGAGCTGCTGGACGAGGTGACC
ACGGCAAAGGTGTGGATCGGTTCGTAG
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ44244
UniProtKB Entry NameQ44244_9PSEU
GenBank Gene IDD30738
General References
  1. Thoden JB, Taylor Ringia EA, Garrett JB, Gerlt JA, Holden HM, Rayment I: Evolution of enzymatic activity in the enolase superfamily: structural studies of the promiscuous o-succinylbenzoate synthase from Amycolatopsis. Biochemistry. 2004 May 18;43(19):5716-27. [Article]
  2. Baxter S, Royer S, Grogan G, Brown F, Holt-Tiffin KE, Taylor IN, Fotheringham IG, Campopiano DJ: An improved racemase/acylase biotransformation for the preparation of enantiomerically pure amino acids. J Am Chem Soc. 2012 Nov 28;134(47):19310-3. doi: 10.1021/ja305438y. Epub 2012 Nov 15. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01646N-AcetylmethionineexperimentalunknownDetails
DB02251O-SuccinylbenzoateexperimentalunknownDetails
DB03299N-Succinyl PhenylglycineexperimentalunknownDetails
DB04511N-Succinyl MethionineexperimentalunknownDetails