Aclacinomycin 10-hydroxylase RdmB
Details
- Name
- Aclacinomycin 10-hydroxylase RdmB
- Synonyms
- 15-demethoxy-epsilon-rhodomycin 10-hydroxylase
- 15-demethoxyaclacinomycin T
- 4.1.1.-
- Gene Name
- rdmB
- Organism
- Streptomyces purpurascens
- Amino acid sequence
>lcl|BSEQ0022287|Aclacinomycin 10-hydroxylase RdmB MSSSSPGEPLEPTDQDLDVLLKNLGNLVTPMALRVAATLRLVDHLLAGADTLAGLADRTD THPQALSRLVRHLTVVGVLEGGEKQGRPLRPTRLGMLLADGHPAQQRAWLDLNGAVSHAD LAFTGLLDVVRTGRPAYAGRYGRPFWEDLSADVALADSFDALMSCDEDLAYEAPADAYDW SAVRHVLDVGGGNGGMLAAIALRAPHLRGTLVELAGPAERARRRFADAGLADRVTVAEGD FFKPLPVTADVVLLSFVLLNWSDEDALTILRGCVRALEPGGRLLVLDRADVEGDGADRFF STLLDLRMLTFMGGRVRTRDEVVDLAGSAGLALASERTSGSTTLPFDFSILEFTAVSEEA APAAQASEALPAQE
- Number of residues
- 374
- Molecular Weight
- 39796.525
- Theoretical pI
- 4.48
- GO Classification
- Functionscarboxy-lyase activity / O-methyltransferase activityProcessesantibiotic biosynthetic process
- General Function
- Not Available
- Specific Function
- Not Available
- Pfam Domain Function
- Methyltransf_2 (PF00891)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0004960|1125 bp GTGAGCTCTTCCTCACCCGGGGAACCCCTGGAACCGACCGACCAGGACCTCGACGTACTC CTGAAGAACCTCGGCAATCTGGTGACCCCGATGGCCCTGAGGGTCGCCGCGACACTCCGC CTGGTCGATCACCTGCTGGCCGGAGCCGACACCCTCGCCGGCCTCGCCGACCGTACGGAC ACCCATCCCCAGGCGCTCTCCCGCCTGGTCCGGCACCTGACCGTCGTCGGCGTCCTGGAG GGCGGCGAGAAGCAGGGCCGGCCGCTGCGCCCCACCCGGCTCGGGATGCTCCTCGCCGAC GGCCACCCGGCCCAGCAGCGGGCCTGGCTGGACCTGAACGGGGCCGTCTCCCACGCCGAC CTGGCCTTCACCGGGCTCCTCGACGTGGTCCGCACCGGCCGCCCCGCCTACGCCGGGCGG TACGGGCGGCCCTTCTGGGAGGACCTCTCGGCGGACGTGGCGCTGGCCGACTCCTTCGAC GCGCTCATGTCCTGCGACGAGGACCTGGCCTACGAGGCCCCGGCCGACGCGTACGACTGG TCGGCGGTCCGGCACGTCCTCGACGTGGGCGGCGGCAACGGCGGCATGCTCGCGGCGATC GCCCTGCGGGCCCCGCACCTGCGCGGCACCCTGGTCGAACTGGCCGGTCCCGCCGAGCGC GCCCGGCGCAGGTTCGCGGACGCCGGTCTGGCCGACCGGGTCACGGTGGCGGAGGGCGAC TTCTTCAAGCCGCTGCCCGTCACCGCCGACGTCGTCCTGCTGTCGTTCGTCCTGCTCAAC TGGTCCGACGAGGACGCGCTGACGATCCTGCGCGGCTGCGTCAGGGCGCTGGAGCCGGGA GGCAGGCTCCTGGTCCTCGACCGTGCCGATGTCGAGGGGGACGGCGCCGACCGGTTCTTC AGCACGCTGCTCGACCTGCGGATGCTGACGTTCATGGGCGGACGGGTGCGCACCCGGGAC GAGGTCGTGGACCTGGCCGGATCGGCCGGACTCGCCCTGGCCTCGGAGCGCACGAGCGGC TCCACGACCCTCCCGTTCGACTTCTCGATCCTCGAGTTCACGGCCGTCTCCGAGGAAGCG GCCCCGGCCGCCCAGGCCTCCGAAGCCCTCCCAGCACAGGAGTAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q54527 UniProtKB Entry Name RDMB_STREF GenBank Gene ID U10405 - General References
- Niemi J, Ylihonko K, Hakala J, Parssinen R, Kopio A, Mantsala P: Hybrid anthracycline antibiotics: production of new anthracyclines by cloned genes from Streptomyces purpurascens in Streptomyces galilaeus. Microbiology. 1994 Jun;140 ( Pt 6):1351-8. [Article]
- Niemi J, Mantsala P: Nucleotide sequences and expression of genes from Streptomyces purpurascens that cause the production of new anthracyclines in Streptomyces galilaeus. J Bacteriol. 1995 May;177(10):2942-5. [Article]
- Wang Y, Niemi J, Airas K, Ylihonko K, Hakala J, Mantsala P: Modifications of aclacinomycin T by aclacinomycin methyl esterase (RdmC) and aclacinomycin-10-hydroxylase (RdmB) from Streptomyces purpurascens. Biochim Biophys Acta. 2000 Jul 14;1480(1-2):191-200. [Article]
- Jansson A, Niemi J, Lindqvist Y, Mantsala P, Schneider G: Crystal structure of aclacinomycin-10-hydroxylase, a S-adenosyl-L-methionine-dependent methyltransferase homolog involved in anthracycline biosynthesis in Streptomyces purpurascens. J Mol Biol. 2003 Nov 21;334(2):269-80. [Article]
- Jansson A, Koskiniemi H, Erola A, Wang J, Mantsala P, Schneider G, Niemi J: Aclacinomycin 10-hydroxylase is a novel substrate-assisted hydroxylase requiring S-adenosyl-L-methionine as cofactor. J Biol Chem. 2005 Feb 4;280(5):3636-44. Epub 2004 Nov 17. [Article]