DNA topoisomerase 4 subunit B
Details
- Name
- DNA topoisomerase 4 subunit B
- Synonyms
- 5.99.1.3
- grlB
- Topoisomerase IV subunit B
- Gene Name
- parE
- Organism
- Bacillus subtilis (strain 168)
- Amino acid sequence
>lcl|BSEQ0037657|DNA topoisomerase 4 subunit B MARKQQFDYNEDAIQVLEGLEAVRKRPGMYIGSTDARGLHHLVYEIVDNSVDEVLAGHGD HIIVKIHKDNSISVQDRGRGMPTGMHKLGKPTPEVILTVLHAGGKFGQGGYKTSGGLHGV GASVVNALSEWLTVTIERDGFVYQQRFENGGKPVTSLEKIGKTKKTGTLTHFKPDPTMFS TTTYNFETLSERLRESAFLLKGLKIELIDERNDQREVFYYENGIEAFVAYLNEEKDVLSE VVSFEGEHHSIEVDFAFQFNDGYSENILSFVNNVRTKDGGTHESGAKTAMTRAFNEYARK VALLKEKDKNLEGTDIREGLSAIISVRIPEELLQFEGQTKGKLGTSEARSAVDAIVSEQL AYFLEENRDTATLLVKKAIKASQAREAARKAREEARSGKKRKKSEATLSGKLTPAGSRNP AKNELYLVEGDSAGGSAKQGRDRRFQAVLPLRGKVINTEKAKLADIFKNEEINTIIHAIG GGVGADFSIDDINYDKIIIMTDADTDGAHIQVLLLTFFYRYMKPLIEHGKVFIALPPLYK VSKGSGKKEIIEYAWSDEEMGDVLKKVGKGYTIQRYKGLGEMNADQLWETTMNPESRTLV RVKIDDAARVERRVTTLMGDKVEPRRKWIEKNVAFGLDEESNILENENLSVAEEV
- Number of residues
- 655
- Molecular Weight
- 73006.17
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / DNA binding / DNA topoisomerase type II (ATP-hydrolyzing) activity / magnesium ion bindingProcesseschromosome segregation / DNA topological change / DNA unwinding involved in DNA replicationComponentschromosome / DNA topoisomerase complex (ATP-hydrolyzing) / nucleoid
- General Function
- Magnesium ion binding
- Specific Function
- Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0015839|DNA topoisomerase 4 subunit B (parE) TTGGCTAGAAAACAGCAATTTGATTACAACGAAGATGCCATACAGGTGCTCGAAGGCCTT GAGGCTGTCAGGAAAAGGCCGGGTATGTATATTGGCTCTACTGACGCGCGGGGTTTGCAC CACTTGGTTTATGAAATTGTAGATAACTCTGTCGACGAGGTGCTTGCCGGCCATGGAGAT CACATAATCGTCAAAATACATAAAGACAATAGTATTTCTGTACAGGATAGAGGCCGCGGC ATGCCGACCGGAATGCATAAGCTCGGCAAACCAACCCCTGAAGTGATTTTAACGGTGCTT CATGCCGGAGGGAAATTCGGCCAAGGCGGCTATAAGACAAGCGGCGGGCTCCACGGAGTT GGTGCATCAGTCGTGAATGCTTTATCTGAATGGCTGACGGTTACCATTGAGCGGGACGGT TTTGTCTATCAGCAGCGATTTGAAAATGGAGGAAAACCGGTTACATCTCTCGAAAAGATC GGCAAAACAAAAAAGACGGGAACTCTTACACACTTTAAGCCAGATCCAACGATGTTCAGC ACAACCACTTATAATTTTGAAACGCTCTCTGAGCGCTTAAGAGAGTCTGCGTTTTTGTTA AAAGGACTGAAAATTGAGCTGATTGATGAACGCAATGACCAGCGTGAGGTCTTTTATTAT GAAAACGGCATAGAAGCGTTTGTTGCTTACTTAAATGAAGAAAAAGACGTCTTGTCTGAA GTGGTCTCGTTTGAGGGTGAGCATCATTCTATAGAAGTGGACTTTGCGTTCCAGTTTAAC GATGGTTATTCTGAAAATATTTTGTCGTTTGTCAACAATGTCAGAACAAAAGACGGCGGG ACGCATGAGTCAGGTGCAAAAACTGCGATGACGCGTGCTTTTAATGAATATGCGCGAAAA GTGGCTTTGCTGAAAGAAAAGGATAAGAACCTTGAAGGCACCGATATAAGGGAAGGGCTT TCAGCCATTATTTCTGTCCGCATTCCTGAGGAGCTTCTTCAATTTGAGGGACAAACAAAA GGAAAGCTCGGTACCAGTGAAGCAAGATCAGCGGTGGATGCGATTGTTTCAGAGCAGCTT GCTTACTTTTTAGAGGAAAATCGGGACACCGCAACGCTTCTTGTCAAAAAAGCAATCAAG GCGAGCCAGGCGCGCGAAGCGGCACGCAAAGCCCGTGAAGAAGCAAGAAGCGGCAAAAAA CGAAAAAAATCAGAAGCGACTTTAAGCGGAAAGCTGACGCCTGCGGGTTCAAGAAACCCG GCAAAAAATGAATTGTATCTCGTTGAGGGAGATTCAGCAGGCGGGTCAGCCAAGCAGGGA CGAGACCGCAGATTCCAGGCGGTTCTGCCTTTACGCGGTAAAGTCATTAATACAGAAAAA GCTAAGCTTGCTGATATCTTTAAAAATGAAGAGATCAATACGATCATTCATGCGATCGGC GGGGGAGTCGGGGCAGATTTCTCAATCGATGACATCAACTACGACAAAATCATCATTATG ACCGATGCCGATACTGACGGCGCCCATATTCAAGTGCTGCTTCTTACCTTTTTCTATCGC TATATGAAACCGCTCATTGAGCATGGCAAGGTGTTCATTGCGCTGCCACCTTTATATAAG GTCAGTAAAGGAAGCGGGAAAAAGGAAATCATTGAATATGCATGGTCTGATGAAGAGATG GGGGATGTCCTGAAAAAAGTCGGCAAAGGCTATACCATTCAACGATATAAGGGTCTTGGA GAGATGAACGCAGACCAGCTGTGGGAAACGACGATGAATCCGGAGTCCCGCACACTTGTT AGGGTCAAAATTGACGATGCGGCACGTGTAGAGAGACGTGTGACGACGTTAATGGGAGAC AAAGTAGAGCCGCGCAGAAAGTGGATTGAGAAAAACGTCGCTTTCGGCTTAGATGAAGAA AGCAATATTTTAGAAAATGAAAACTTATCGGTCGCTGAGGAGGTTTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q59192 UniProtKB Entry Name PARE_BACSU - General References
- Rose M, Entian KD: New genes in the 170 degrees region of the Bacillus subtilis genome encode DNA gyrase subunits, a thioredoxin, a xylanase and an amino acid transporter. Microbiology. 1996 Nov;142 ( Pt 11):3097-101. [Article]
- Huang WM, Libbey JL, van der Hoeven P, Yu SX: Bipolar localization of Bacillus subtilis topoisomerase IV, an enzyme required for chromosome segregation. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4652-7. [Article]
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