NADP-dependent glyceraldehyde-3-phosphate dehydrogenase
Details
- Name
- NADP-dependent glyceraldehyde-3-phosphate dehydrogenase
- Synonyms
- 1.2.1.9
- Glyceraldehyde-3-phosphate dehydrogenase [NADP(+)]
- Non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase
- Triosephosphate dehydrogenase
- Gene Name
- gapN
- Organism
- Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
- Amino acid sequence
>lcl|BSEQ0011917|NADP-dependent glyceraldehyde-3-phosphate dehydrogenase MTKQYKNYVNGEWKLSENEIKIYEPASGAELGSVPAMSTEEVDYVYASAKKAQPAWRSLS YIERAAYLHKVADILMRDKEKIGAVLSKEVAKGYKSAVSEVVRTAEIINYAAEEGLRMEG EVLEGGSFEAASKKKIAVVRREPVGLVLAISPFNYPVNLAGSKIAPALIAGNVIAFKPPT QGSISGLLLAEAFAEAGLPAGVFNTITGRGSEIGDYIVEHQAVNFINFTGSTGIGERIGK MAGMRPIMLELGGKDSAIVLEDADLELTAKNIIAGAFGYSGQRCTAVKRVLVMESVADEL VEKIREKVLALTIGNPEDDADITPLIDTKSADYVEGLINDANDKGAAALTEIKREGNLIC PILFDKVTTDMRLAWEEPFGPVLPIIRVTSVEEAIEISNKSEYGLQASIFTNDFPRAFGI AEQLEVGTVHINNKTQRGTDNFPFLGAKKSGAGIQGVKYSIEAMTTVKSVVFDIK
- Number of residues
- 475
- Molecular Weight
- 51193.14
- Theoretical pI
- 4.83
- GO Classification
- Functionsglyceraldehyde-3-phosphate dehydrogenase (NADP+) (non-phosphorylating) activity / glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity
- General Function
- Glyceraldehyde-3-phosphate dehydrogenase (nadp+) (phosphorylating) activity
- Specific Function
- Not Available
- Pfam Domain Function
- Aldedh (PF00171)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0011918|NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (gapN) TTGACAAAACAATATAAAAATTATGTCAATGGCGAGTGGAAGCTTTCAGAAAATGAAATT AAAATCTACGAACCGGCCAGTGGAGCTGAATTGGGTTCAGTTCCAGCAATGAGTACTGAA GAAGTAGATTATGTTTATGCTTCAGCCAAGAAAGCTCAACCAGCTTGGCGATCACTTTCA TACATAGAACGTGCTGCCTACCTTCATAAGGTAGCAGATATTTTGATGCGTGATAAAGAA AAAATAGGTGCTGTTCTTTCCAAAGAGGTTGCTAAAGGTTATAAATCAGCAGTCAGCGAA GTTGTTCGTACTGCAGAAATCATTAATTATGCAGCTGAAGAAGGCCTTCGTATGGAAGGT GAAGTCCTTGAAGGCGGCAGTTTTGAAGCAGCCAGCAAGAAAAAAATTGCCGTTGTTCGT CGTGAACCAGTAGGTCTTGTATTAGCTATTTCACCATTTAACTACCCTGTTAACTTGGCA GGTTCGAAAATTGCACCGGCTCTTATTGCGGGAAATGTTATTGCTTTTAAACCACCGACG CAAGGATCAATCTCAGGGCTCTTACTTGCTGAAGCATTTGCTGAAGCTGGACTTCCTGCA GGTGTCTTTAATACCATTACAGGTCGTGGTTCTGAAATTGGAGACTATATTGTAGAACAT CAAGCCGTTAACTTTATCAATTTCACTGGTTCAACAGGAATTGGGGAACGTATTGGCAAA ATGGCTGGTATGCGTCCGATTATGCTTGAACTCGGTGGAAAAGATTCAGCCATCGTTCTT GAAGATGCAGACCTTGAATTGACTGCTAAAAATATTATTGCAGGTGCTTTTGGTTATTCA GGTCAACGCTGTACAGCAGTTAAACGTGTTCTTGTGATGGAAAGTGTTGCTGATGAACTG GTCGAAAAAATCCGTGAAAAAGTTCTTGCATTAACAATTGGTAATCCAGAAGACGATGCA GATATTACACCGTTGATTGATACAAAATCAGCTGATTATGTAGAAGGTCTTATTAATGAT GCCAATGATAAAGGAGCCGCTGCCCTTACTGAAATCAAACGTGAAGGTAATCTTATCTGT CCAATCCTCTTTGATAAGGTAACGACAGATATGCGTCTTGCTTGGGAAGAACCATTTGGT CCTGTTCTTCCGATCATTCGTGTGACATCTGTAGAAGAAGCCATTGAAATTTCTAACAAA TCGGAATATGGACTTCAGGCTTCTATCTTTACAAATGATTTCCCACGCGCTTTTGGTATT GCTGAGCAGCTTGAAGTTGGTACAGTTCATATCAATAATAAGACACAGCGCGGTACGGAC AACTTCCCATTCTTAGGGGCTAAAAAATCAGGTGCAGGTATTCAAGGGGTAAAATATTCT ATTGAAGCTATGACAACTGTTAAATCCGTCGTATTTGATATCAAATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q59931 UniProtKB Entry Name GAPN_STRMU GenBank Gene ID L38521 - General References
- Boyd DA, Cvitkovitch DG, Hamilton IR: Sequence, expression, and function of the gene for the nonphosphorylating, NADP-dependent glyceraldehyde-3-phosphate dehydrogenase of Streptococcus mutans. J Bacteriol. 1995 May;177(10):2622-7. [Article]
- Ajdic D, McShan WM, McLaughlin RE, Savic G, Chang J, Carson MB, Primeaux C, Tian R, Kenton S, Jia H, Lin S, Qian Y, Li S, Zhu H, Najar F, Lai H, White J, Roe BA, Ferretti JJ: Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14434-9. Epub 2002 Oct 23. [Article]
- Cobessi D, Tete-Favier F, Marchal S, Azza S, Branlant G, Aubry A: Apo and holo crystal structures of an NADP-dependent aldehyde dehydrogenase from Streptococcus mutans. J Mol Biol. 1999 Jul 2;290(1):161-73. [Article]
- Cobessi D, Tete-Favier F, Marchal S, Branlant G, Aubry A: Structural and biochemical investigations of the catalytic mechanism of an NADP-dependent aldehyde dehydrogenase from Streptococcus mutans. J Mol Biol. 2000 Jun 30;300(1):141-52. [Article]
- Pailot A, D'Ambrosio K, Corbier C, Talfournier F, Branlant G: Invariant Thr244 is essential for the efficient acylation step of the non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase from Streptococcus mutans. Biochem J. 2006 Dec 15;400(3):521-30. [Article]