DNA topoisomerase 4 subunit B
Details
- Name
- DNA topoisomerase 4 subunit B
- Synonyms
- 5.99.1.3
- Topoisomerase IV subunit B
- Gene Name
- parE
- Organism
- Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
- Amino acid sequence
>lcl|BSEQ0012600|DNA topoisomerase 4 subunit B MSKKEININNYNDDAIQVLEGLDAVRKRPGMYIGSTDGAGLHHLVWEIVDNAVDEALSGF GDRIDVTINKDGSLTVQDHGRGMPTGMHAMGIPTVEVIFTILHAGGKFGQGGYKTSGGLH GVGSSVVNALSSWLEVEITRDGAVYKQRFENGGKPVTTLKKIGTAPKSKTGTKVTFMPDA TIFSTTDFKYNTISERLNESAFLLKNVTLSLTDKRTNEAIEFHYENGVQDFVSYLNEDKE ILTPVLYFEGEDNGFQVEVALQYNDGFSDNILSFVNNVRTKDGGTHETGLKSAITKVMND YARKTGLLKEKDKNLEGSDYREGLAAVLSILVPEEHLQFEGQTKDKLGSPLARPVVDGIV ADKLTFFLMENGELASNLIRKAIKARDAREAARKARDESRNGKKNKKDKGLLSGKLTPAQ SKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVVNTAKAKMADILKNEEINTMI YTIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIALP PLYKMSKGKGKKEEVAYAWTDGELEELRKQFGKGATLQRYKGLGEMNADQLWETTMNPET RTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFTLEETTVF
- Number of residues
- 647
- Molecular Weight
- 71663.86
- Theoretical pI
- 6.77
- GO Classification
- FunctionsATP binding / DNA binding / DNA topoisomerase type II (ATP-hydrolyzing) activity / magnesium ion bindingProcesseschromosome segregation / DNA topological changeComponentschromosome
- General Function
- Magnesium ion binding
- Specific Function
- Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0012601|DNA topoisomerase 4 subunit B (parE) GTGTCAAAAAAGGAAATCAATATTAACAATTATAATGATGATGCTATTCAGGTGCTAGAA GGGTTGGATGCGGTCCGAAAACGTCCAGGGATGTATATTGGATCGACCGATGGCGCTGGT CTTCATCACCTAGTTTGGGAAATCGTTGATAATGCAGTCGATGAAGCCTTGTCTGGGTTT GGTGATCGTATTGATGTAACTATCAATAAAGACGGTAGTCTAACGGTTCAAGACCATGGA CGTGGGATGCCGACAGGTATGCACGCTATGGGAATTCCAACTGTTGAGGTTATCTTTACC ATTCTTCATGCCGGAGGGAAATTCGGTCAAGGTGGCTATAAGACATCAGGTGGACTTCAC GGAGTGGGTTCTTCCGTTGTTAACGCCCTTTCTAGCTGGTTAGAAGTTGAAATTACCCGT GATGGCGCAGTTTACAAGCAACGTTTCGAAAATGGTGGAAAACCTGTCACGACTTTGAAG AAAATCGGTACAGCACCCAAGTCTAAAACAGGCACCAAAGTTACTTTTATGCCTGACGCG ACTATATTTTCTACGACAGATTTCAAGTACAATACCATTTCAGAGCGCCTTAATGAATCA GCCTTTCTCTTGAAAAATGTGACCTTGTCTTTAACGGACAAGCGAACAAATGAAGCGATT GAGTTCCACTATGAGAATGGAGTACAAGATTTTGTTTCTTATCTCAACGAAGATAAGGAA ATCTTGACGCCAGTTCTTTACTTTGAAGGGGAAGACAATGGTTTTCAAGTGGAAGTAGCC CTCCAGTACAATGACGGATTCTCAGATAACATTCTATCTTTTGTCAATAACGTTCGCACC AAGGACGGTGGAACGCACGAGACAGGACTCAAGTCTGCCATTACCAAGGTCATGAATGAC TATGCACGTAAAACAGGTCTTCTCAAGGAAAAAGATAAAAACCTTGAAGGTTCAGACTAT CGTGAGGGACTAGCGGCCGTTCTTTCTATCTTAGTTCCTGAAGAACACTTGCAGTTTGAA GGACAGACCAAGGATAAACTAGGAAGCCCCCTAGCTCGCCCAGTTGTGGATGGAATAGTG GCTGATAAGTTGACCTTTTTCCTTATGGAAAATGGGGAATTAGCTTCTAACCTCATCCGC AAGGCTATCAAGGCCCGTGATGCTCGTGAAGCAGCACGTAAGGCGCGTGATGAGAGCCGA AATGGGAAGAAAAACAAGAAAGATAAGGGCTTGTTGTCTGGGAAATTGACCCCAGCCCAA TCTAAGAATCCTGCTAAGAATGAACTCTATCTAGTTGAGGGGGACTCTGCCGGTGGTTCT GCCAAACAAGGTCGTGACCGCAAGTTCCAGGCTATTCTACCTCTTCGTGGTAAGGTTGTC AATACAGCCAAGGCCAAGATGGCGGATATCCTCAAAAATGAAGAGATCAATACCATGATT TATACCATTGGTGCGGGTGTTGGAGCAGACTTCTCTATTGAAGATGCCAACTATGATAAG ATCATTATCATGACCGATGCGGATACCGACGGTGCCCATATCCAGACCTTGCTCTTGACA TTTTTCTACCGTTACATGCGTCCGCTAGTCGAGGCAGGTCATGTCTATATTGCCCTCCCA CCTCTTTACAAGATGTCCAAAGGTAAAGGCAAGAAAGAAGAAGTGGCCTACGCTTGGACG GACGGAGAACTAGAAGAACTCCGTAAACAGTTCGGTAAAGGCGCTACCCTCCAACGATAC AAAGGACTTGGTGAGATGAATGCGGACCAGCTCTGGGAAACAACCATGAACCCAGAAACA CGTACCCTCATCCGTGTCACAATTGAAGATTTAGCGCGCGCCGAACGCCGCGTCAATGTT CTCATGGGAGATAAGGTAGAACCACGCCGTAAATGGATTGAAGATAATGTCAAGTTTACG CTAGAAGAAACGACAGTGTTTTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q59961 UniProtKB Entry Name PARE_STRPN GenBank Protein ID 1490399 GenBank Gene ID Z67739 - General References
- Pan XS, Fisher LM: Cloning and characterization of the parC and parE genes of Streptococcus pneumoniae encoding DNA topoisomerase IV: role in fluoroquinolone resistance. J Bacteriol. 1996 Jul;178(14):4060-9. [Article]
- Tettelin H, Nelson KE, Paulsen IT, Eisen JA, Read TD, Peterson S, Heidelberg J, DeBoy RT, Haft DH, Dodson RJ, Durkin AS, Gwinn M, Kolonay JF, Nelson WC, Peterson JD, Umayam LA, White O, Salzberg SL, Lewis MR, Radune D, Holtzapple E, Khouri H, Wolf AM, Utterback TR, Hansen CL, McDonald LA, Feldblyum TV, Angiuoli S, Dickinson T, Hickey EK, Holt IE, Loftus BJ, Yang F, Smith HO, Venter JC, Dougherty BA, Morrison DA, Hollingshead SK, Fraser CM: Complete genome sequence of a virulent isolate of Streptococcus pneumoniae. Science. 2001 Jul 20;293(5529):498-506. [Article]
- Munoz R, De La Campa AG: ParC subunit of DNA topoisomerase IV of Streptococcus pneumoniae is a primary target of fluoroquinolones and cooperates with DNA gyrase A subunit in forming resistance phenotype. Antimicrob Agents Chemother. 1996 Oct;40(10):2252-7. [Article]
- Laponogov I, Veselkov DA, Sohi MK, Pan XS, Achari A, Yang C, Ferrara JD, Fisher LM, Sanderson MR: Breakage-reunion domain of Streptococcus pneumoniae topoisomerase IV: crystal structure of a gram-positive quinolone target. PLoS One. 2007 Mar 21;2(3):e301. [Article]
- Laponogov I, Sohi MK, Veselkov DA, Pan XS, Sawhney R, Thompson AW, McAuley KE, Fisher LM, Sanderson MR: Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases. Nat Struct Mol Biol. 2009 Jun;16(6):667-9. doi: 10.1038/nsmb.1604. Epub 2009 May 17. [Article]
- Laponogov I, Pan XS, Veselkov DA, McAuley KE, Fisher LM, Sanderson MR: Structural basis of gate-DNA breakage and resealing by type II topoisomerases. PLoS One. 2010 Jun 28;5(6):e11338. doi: 10.1371/journal.pone.0011338. [Article]