Heterochromatin protein 1-binding protein 3
Details
- Name
- Heterochromatin protein 1-binding protein 3
- Synonyms
- Protein HP1-BP74
- Gene Name
- HP1BP3
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0049911|Heterochromatin protein 1-binding protein 3 MATDTSQGELVHPKALPLIVGAQLIHADKLGEKVEDSTMPIRRTVNSTRETPPKSKLAEG EEEKPEPDISSEESVSTVEEQENETPPATSSEAEQPKGEPENEEKEENKSSEETKKDEKD QSKEKEKKVKKTIPSWATLSASQLARAQKQTPMASSPRPKMDAILTEAIKACFQKSGASV VAIRKYIIHKYPSLELERRGYLLKQALKRELNRGVIKQVKGKGASGSFVVVQKSRKTPQK SRNRKNRSSAVDPEPQVKLEDVLPLAFTRLCEPKEASYSLIRKYVSQYYPKLRVDIRPQL LKNALQRAVERGQLEQITGKGASGTFQLKKSGEKPLLGGSLMEYAILSAIAAMNEPKTCS TTALKKYVLENHPGTNSNYQMHLLKKTLQKCEKNGWMEQISGKGFSGTFQLCFPYYPSPG VLFPKKEPDDSRDEDEDEDESSEEDSEDEEPPPKRRLQKKTPAKSPGKAASVKQRGSKPA PKVSAAQRGKARPLPKKAPPKAKTPAKKTRPSSTVIKKPSGGSSKKPATSARKEVKLPGK GKSTMKKSFRVKK
- Number of residues
- 553
- Molecular Weight
- 61206.5
- Theoretical pI
- Not Available
- GO Classification
- FunctionsDNA binding / nucleosome bindingProcessescellular response to hypoxia / heterochromatin organization / nucleosome assembly / regulation of cell proliferation / regulation of nucleus size / regulation of transcription, DNA-templatedComponentschromosome / nuclear speck / nucleosome / nucleus
- General Function
- Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal(PubMed:25100860).
- Specific Function
- Dna binding
- Pfam Domain Function
- Linker_histone (PF00538)
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0049912|Heterochromatin protein 1-binding protein 3 (HP1BP3) ATGGCGACTGATACGTCTCAAGGTGAACTCGTCCATCCTAAGGCACTCCCACTTATAGTA GGAGCTCAGCTGATCCACGCGGACAAGTTAGGTGAGAAGGTAGAAGATAGCACCATGCCG ATTCGTCGAACTGTGAATTCTACCCGGGAAACTCCTCCCAAAAGCAAGCTTGCTGAAGGG GAGGAAGAAAAGCCAGAACCAGACATAAGTTCAGAGGAATCTGTCTCCACTGTAGAAGAA CAAGAGAATGAAACTCCACCTGCTACTTCGAGTGAGGCAGAGCAGCCAAAGGGGGAACCT GAGAATGAAGAGAAGGAAGAAAATAAGTCTTCTGAGGAAACCAAAAAGGATGAGAAAGAT CAGTCTAAAGAAAAGGAGAAGAAAGTGAAAAAAACAATTCCTTCCTGGGCTACCCTTTCT GCCAGCCAGCTAGCCAGGGCCCAGAAACAAACACCGATGGCTTCTTCCCCACGTCCCAAG ATGGATGCAATCTTAACTGAGGCCATTAAGGCATGCTTCCAGAAGAGTGGTGCATCAGTG GTTGCTATTCGAAAATACATCATCCATAAGTATCCTTCTCTGGAGCTGGAGAGAAGGGGT TATCTCCTTAAACAAGCACTGAAAAGAGAATTAAATAGAGGAGTCATCAAACAGGTTAAA GGAAAAGGTGCTTCTGGAAGTTTTGTTGTGGTTCAGAAATCAAGAAAAACACCTCAGAAA TCCAGAAACAGAAAGAATAGGAGCTCTGCAGTGGATCCAGAACCACAAGTAAAATTGGAG GATGTCCTCCCACTGGCCTTTACTCGCCTTTGTGAACCTAAAGAAGCTTCCTACAGTCTC ATCAGGAAATATGTGTCTCAGTATTATCCTAAGCTTAGAGTGGACATCAGGCCTCAGCTG TTGAAGAACGCTCTGCAGAGAGCAGTAGAGAGGGGCCAGTTAGAACAGATAACTGGCAAA GGTGCTTCGGGGACATTCCAGCTGAAGAAATCAGGGGAGAAACCCCTGCTTGGTGGAAGC CTGATGGAATATGCAATCTTGTCTGCCATTGCTGCCATGAATGAGCCGAAGACCTGCTCT ACCACTGCTCTGAAGAAGTATGTCCTAGAGAATCACCCAGGAACCAATTCTAACTATCAA ATGCATTTGCTGAAAAAAACCCTGCAGAAATGCGAAAAGAATGGGTGGATGGAACAGATC TCTGGGAAAGGGTTCAGTGGCACCTTCCAGCTCTGTTTTCCCTATTATCCCAGCCCAGGA GTTCTGTTTCCGAAGAAAGAGCCAGATGATTCTAGAGATGAGGATGAAGATGAAGATGAG TCATCAGAAGAAGACTCTGAGGATGAAGAGCCGCCACCTAAGAGAAGGTTGCAGAAGAAA ACCCCAGCCAAGTCCCCAGGGAAGGCCGCATCTGTGAAGCAGAGAGGGTCCAAACCTGCA CCTAAAGTCTCAGCTGCCCAGCGGGGGAAAGCTAGGCCCTTGCCTAAGAAAGCACCTCCT AAGGCCAAAACGCCTGCCAAGAAGACCAGACCCTCATCCACAGTCATCAAGAAACCTAGT GGTGGCTCCTCAAAGAAGCCTGCAACCAGTGCAAGAAAGGAAGTAAAATTGCCGGGCAAG GGCAAATCCACCATGAAGAAGTCTTTCAGAGTGAAAAAGTAA
- Chromosome Location
- 1
- Locus
- 1p36.12
- External Identifiers
Resource Link UniProtKB ID Q5SSJ5 UniProtKB Entry Name HP1B3_HUMAN HGNC ID HGNC:24973 - General References
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