DNA oxidative demethylase ALKBH2
Details
- Name
- DNA oxidative demethylase ALKBH2
- Synonyms
- 1.14.11.33
- ABH2
- Alkylated DNA repair protein alkB homolog 2
- Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2
- Oxy DC1
- Gene Name
- ALKBH2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0004327|DNA oxidative demethylase ALKBH2 MDRFLVKGAQGGLLRKQEEQEPTGEEPAVLGGDKESTRKRPRREAPGNGGHSAGPSWRHI RAEGLDCSYTVLFGKAEADEIFQELEKEVEYFTGALARVQVFGKWHSVPRKQATYGDAGL TYTFSGLTLSPKPWIPVLERIRDHVSGVTGQTFNFVLINRYKDGCDHIGEHRDDERELAP GSPIASVSFGACRDFVFRHKDSRGKSPSRRVAVVRLPLAHGSLLMMNHPTNTHWYHSLPV RKKVLAPRVNLTFRKILLTKK
- Number of residues
- 261
- Molecular Weight
- 29322.22
- Theoretical pI
- 10.22
- GO Classification
- Functionscytosine C-5 DNA demethylase activity / DNA-N1-methyladenine dioxygenase activity / ferrous iron bindingProcessesDNA dealkylation involved in DNA repair / DNA demethylation / DNA repair / oxidative demethylation / oxidative DNA demethylationComponentsmicrotubule cytoskeleton / nucleoplasm / nucleus
- General Function
- Ferrous iron binding
- Specific Function
- Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.
- Pfam Domain Function
- 2OG-FeII_Oxy_2 (PF13532)
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0020600|DNA oxidative demethylase ALKBH2 (ALKBH2) ATGGACAGATTCCTGGTGAAAGGGGCTCAAGGGGGCCTTTTGAGGAAGCAGGAGGAGCAA GAGCCAACTGGAGAAGAGCCAGCTGTGTTGGGAGGAGACAAAGAAAGCACAAGGAAGAGG CCCAGGAGAGAGGCCCCAGGGAATGGAGGCCACTCAGCAGGCCCTAGCTGGCGGCACATT CGGGCTGAGGGCCTGGACTGCAGTTACACAGTCCTGTTTGGCAAAGCTGAGGCAGATGAG ATTTTCCAAGAGTTGGAGAAAGAAGTAGAATATTTTACAGGAGCACTGGCCAGAGTCCAG GTATTCGGGAAGTGGCACAGTGTGCCCAGGAAGCAGGCAACGTATGGCGACGCTGGGCTG ACCTACACATTTTCAGGCCTCACGCTGTCTCCAAAGCCCTGGATCCCAGTTCTAGAGCGC ATCCGGGATCACGTCTCTGGGGTGACTGGACAGACCTTCAACTTTGTGCTCATCAACAGG TATAAAGATGGCTGTGACCACATCGGGGAGCACCGAGATGATGAAAGAGAACTGGCCCCT GGGAGCCCCATTGCCTCTGTCTCCTTCGGTGCCTGCAGAGACTTTGTCTTCCGGCATAAG GATTCCCGTGGGAAAAGCCCCTCCAGGAGGGTGGCGGTGGTCAGGCTGCCGCTGGCCCAC GGGAGCTTACTAATGATGAACCACCCGACCAACACGCACTGGTACCACAGTCTTCCCGTG AGAAAGAAGGTTCTGGCTCCACGGGTGAATCTGACTTTTCGTAAAATTTTGCTTACTAAA AAATAA
- Chromosome Location
- 12
- Locus
- 12q24.11
- External Identifiers
Resource Link UniProtKB ID Q6NS38 UniProtKB Entry Name ALKB2_HUMAN GenBank Protein ID 53988530 GenBank Gene ID AY754389 GenAtlas ID ALKBH2 HGNC ID HGNC:32487 - General References
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