Reverse transcriptase/RNaseH
Details
- Name
- Reverse transcriptase/RNaseH
- Synonyms
- Not Available
- Gene Name
- pol
- Organism
- Human immunodeficiency virus 1
- Amino acid sequence
>lcl|BSEQ0012880|Reverse transcriptase/RNaseH PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK GIGGNEQVDKLVSAGIRKVLFLDGID
- Number of residues
- 566
- Molecular Weight
- 65223.615
- Theoretical pI
- 8.45
- GO Classification
- Functionsidentical protein binding / metal ion binding / nucleic acid binding / RNA-directed DNA polymerase activity / RNA-DNA hybrid ribonuclease activity
- General Function
- Rna-dna hybrid ribonuclease activity
- Specific Function
- Not Available
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q72547 UniProtKB Entry Name Q72547_9HIV1 GenBank Protein ID 896047 GenBank Gene ID U28646 - General References
- Jones LH, Allan G, Barba O, Burt C, Corbau R, Dupont T, Knochel T, Irving S, Middleton DS, Mowbray CE, Perros M, Ringrose H, Swain NA, Webster R, Westby M, Phillips C: Novel indazole non-nucleoside reverse transcriptase inhibitors using molecular hybridization based on crystallographic overlays. J Med Chem. 2009 Feb 26;52(4):1219-23. doi: 10.1021/jm801322h. [Article]
- Kirschberg TA, Balakrishnan M, Squires NH, Barnes T, Brendza KM, Chen X, Eisenberg EJ, Jin W, Kutty N, Leavitt S, Liclican A, Liu Q, Liu X, Mak J, Perry JK, Wang M, Watkins WJ, Lansdon EB: RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information. J Med Chem. 2009 Oct 8;52(19):5781-4. doi: 10.1021/jm900597q. [Article]
- Lansdon EB, Liu Q, Leavitt SA, Balakrishnan M, Perry JK, Lancaster-Moyer C, Kutty N, Liu X, Squires NH, Watkins WJ, Kirschberg TA: Structural and binding analysis of pyrimidinol carboxylic acid and N-hydroxy quinazolinedione HIV-1 RNase H inhibitors. Antimicrob Agents Chemother. 2011 Jun;55(6):2905-15. doi: 10.1128/AAC.01594-10. Epub 2011 Apr 4. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00300 Tenofovir disoproxil approved, investigational yes inhibitor Details DB07935 5-[(5-fluoro-3-methyl-1H-indazol-4-yl)oxy]benzene-1,3-dicarbonitrile experimental unknown Details DB01048 Abacavir approved, investigational yes inhibitor Details DB00705 Delavirdine approved yes inhibitor Details DB00900 Didanosine approved yes inhibitor Details DB00625 Efavirenz approved, investigational yes inhibitor Details DB00879 Emtricitabine approved, investigational yes inhibitor Details DB00709 Lamivudine approved, investigational yes inhibitor Details DB00238 Nevirapine approved yes inhibitor Details DB00649 Stavudine approved, investigational yes inhibitor Details DB00943 Zalcitabine approved, investigational yes inhibitor Details DB00495 Zidovudine approved yes inhibitor Details DB08864 Rilpivirine approved yes inhibitor Details DB09299 Tenofovir alafenamide approved yes inhibitor Details DB11365 Sennosides experimental unknown inhibitor Details DB11799 Bictegravir approved, investigational yes antagonist Details DB12855 Apricitabine investigational unknown inhibitor Details DB12301 Doravirine approved, investigational unknown inhibitor Details DB14126 Tenofovir experimental, investigational yes inhibitor Details DB12753 Racivir investigational unknown inhibitor Details DB12470 Dexelvucitabine investigational unknown inhibitor Details DB06236 Elvucitabine investigational unknown inhibitor Details DB06198 Alovudine investigational unknown inhibitor Details DB06619 Amdoxovir investigational unknown inhibitor Details DB08502 Capravirine investigational unknown inhibitor Details DB06414 Etravirine approved unknown inhibitor Details