Alpha-pyrone synthesis polyketide synthase-like Pks18
Details
- Name
- Alpha-pyrone synthesis polyketide synthase-like Pks18
- Synonyms
- 2.3.1.-
- Alpha-pyrone synthesis polyketide synthase type III Pks18
- Chalcone synthase-like protein
- CHS-like
- Gene Name
- pks18
- Organism
- Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
- Amino acid sequence
>lcl|BSEQ0051264|Alpha-pyrone synthesis polyketide synthase-like Pks18 MNVSAESGAPRRAGQRHEVGLAQLPPAPPTTVAVIEGLATGTPRRVVNQSDAADRVAELF LDPGQRERIPRVYQKSRITTRRMAVDPLDAKFDVFRREPATIRDRMHLFYEHAVPLAVDV SKRALAGLPYRAAEIGLLVLATSTGFIAPGVDVAIVKELGLSPSISRVVVNFMGCAAAMN ALGTATNYVRAHPAMKALVVCIELCSVNAVFADDINDVVIHSLFGDGCAALVIGASQVQE KLEPGKVVVRSSFSQLLDNTEDGIVLGVNHNGITCELSENLPGYIFSGVAPVVTEMLWDN GLQISDIDLWAIHPGGPKIIEQSVRSLGISAELAAQSWDVLARFGNMLSVSLIFVLETMV QQAESAKAISTGVAFAFGPGVTVEGMLFDIIRR
- Number of residues
- 393
- Molecular Weight
- 42032.07
- Theoretical pI
- Not Available
- GO Classification
- Functionstransferase activity, transferring acyl groups other than amino-acyl groupsProcesseschalcone biosynthetic process / fatty acid biosynthetic process
- General Function
- Involved in the biosynthesis of tri- and tetraketide alpha-pyrones. Pks18 catalyzes the extension of medium- and long-chain aliphatic acyl-CoA substrates by using malonyl-CoA as an extender molecule to synthesize polyketide products.
- Specific Function
- Transferase activity, transferring acyl groups other than amino-acyl groups
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0051265|Alpha-pyrone synthesis polyketide synthase-like Pks18 (pks18) ATGAACGTCTCAGCTGAGAGCGGTGCGCCGCGCCGGGCCGGCCAGAGGCATGAGGTTGGC CTTGCCCAGTTGCCGCCGGCTCCGCCCACCACGGTGGCGGTGATTGAAGGGCTTGCGACG GGCACGCCGCGTCGGGTAGTCAACCAGTCCGACGCCGCCGATCGGGTCGCCGAGCTTTTC CTCGATCCCGGTCAGCGGGAACGGATTCCGCGGGTGTATCAAAAATCGCGGATCACCACG CGCCGGATGGCGGTCGACCCGCTCGACGCCAAATTTGATGTCTTCAGGCGGGAACCTGCG ACGATCCGTGATCGGATGCATCTGTTCTACGAACACGCGGTTCCGCTGGCGGTGGACGTG AGCAAGCGTGCCCTGGCCGGCCTGCCATACCGTGCCGCCGAGATCGGGCTGCTGGTGTTG GCCACCAGCACCGGATTCATCGCGCCGGGCGTGGACGTTGCGATCGTCAAAGAGCTCGGG CTCTCCCCGTCGATATCACGTGTCGTGGTCAATTTCATGGGATGTGCCGCCGCGATGAAT GCCCTGGGCACCGCCACCAACTATGTTCGTGCCCACCCGGCCATGAAGGCGCTGGTGGTG TGTATCGAATTGTGCTCGGTGAACGCTGTTTTTGCCGACGACATCAACGACGTCGTCATT CACAGCTTGTTTGGCGACGGGTGCGCGGCGTTGGTGATCGGCGCCAGCCAGGTTCAGGAG AAGCTCGAGCCAGGCAAGGTGGTAGTCCGCAGTAGTTTCAGTCAGCTGCTCGACAACACC GAAGACGGTATCGTGCTTGGCGTCAATCACAACGGCATCACCTGCGAGCTGTCGGAGAAT CTCCCCGGCTACATCTTCAGCGGGGTCGCACCGGTGGTGACAGAGATGTTATGGGACAAT GGATTACAGATATCCGATATCGATCTCTGGGCGATCCATCCGGGTGGCCCCAAGATCATC GAGCAGTCGGTGCGCTCGCTGGGGATCTCCGCGGAGCTGGCGGCGCAGAGCTGGGACGTG CTCGCCCGCTTCGGCAACATGCTCAGCGTATCGCTTATCTTTGTGCTAGAGACGATGGTG CAGCAGGCGGAGTCGGCCAAAGCCATCTCGACGGGGGTGGCGTTCGCGTTCGGGCCGGGC GTCACTGTCGAAGGCATGCTGTTCGACATCATCCGACGGTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P9WPF1 UniProtKB Entry Name PKS18_MYCTU - General References
- Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. [Article]
- Saxena P, Yadav G, Mohanty D, Gokhale RS: A new family of type III polyketide synthases in Mycobacterium tuberculosis. J Biol Chem. 2003 Nov 7;278(45):44780-90. Epub 2003 Aug 26. [Article]
- Sankaranarayanan R, Saxena P, Marathe UB, Gokhale RS, Shanmugam VM, Rukmini R: A novel tunnel in mycobacterial type III polyketide synthase reveals the structural basis for generating diverse metabolites. Nat Struct Mol Biol. 2004 Sep;11(9):894-900. Epub 2004 Aug 1. [Article]