Elongation factor Tu GTP-binding domain-containing protein 1
Details
- Name
- Elongation factor Tu GTP-binding domain-containing protein 1
- Synonyms
- EFL1
- Elongation factor-like 1
- FAM42A
- Protein FAM42A
- Gene Name
- EFTUD1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0007744|Elongation factor Tu GTP-binding domain-containing protein 1 MVLNSLDKMIQLQKNTANIRNICVLAHVDHGKTTLADCLISSNGIISSRLAGKLRYMDSR EDEQIRGITMKSSAISLHYATGNEEYLINLIDSPGHVDFSSEVSTAVRICDGCIIVVDAV EGVCPQTQAVLRQAWLENIRPVLVINKIDRLIVELKFTPQEAYSHLKNILEQINALTGTL FTSKVLEERAERETESQVNPNSEQGEQVYDWSTGLEDTDDSHLYFSPEQGNVVFTSAIDG WGFGIEHFARIYSQKIGIKKEVLMKTLWGDYYINMKAKKIMKGDQAKGKKPLFVQLILEN IWSLYDAVLKKDKDKIDKIVTSLGLKIGAREARHSDPKVQINAICSQWLPISHAVLAMVC QKLPSPLDITAERVERLMCTGSQTFDSFPPETQALKAAFMKCGSEDTAPVIIFVSKMFAV DAKALPQNKPRPLTQEEIAQRRERARQRHAEKLAAAQGQAPLEPTQDGSAIETCPKGEEP RGDEQQVESMTPKPVLQEENNQESFIAFARVFSGVARRGKKIFVLGPKYSPLEFLRRVPL GFSAPPDGLPQVPHMAYCALENLYLLMGRELEYLEEVPPGNVLGIGGLQDFVLKSATLCS LPSCPPFIPLNFEATPIVRVAVEPKHPSEMPQLVKGMKLLNQADPCVQILIQETGEHVLV TAGEVHLQRCLDDLKERFAKIHISVSEPIIPFRETITKPPKVDMVNEEIGKQQKVAVIHQ MKEDQSKIPEGIQVDSDGLITITTPNKLATLSVRAMPLPEEVTQILEENSDLIRSMEQLT SSLNEGENTHMIHQKTQEKIWEFKGKLEQHLTGRRWRNIVDQIWSFGPRKCGPNILVNKS EDFQNSVWTGPADKASKEASRYRDLGNSIVSGFQLATLSGPMCEEPLMGVCFVLEKWDLS KFEEQGASDLAKEGQEENETCSGGNENQELQDGCSEAFEKRTSQKGESPLTDCYGPFSGQ LIATMKEACRYALQVKPQRLMAAMYTCDIMATGDVLGRVYAVLSKREGRVLQEEMKEGTD MFIIKAVLPVAESFGFADEIRKRTSGLASPQLVFSHWEIIPSDPFWVPTTEEEYLHFGEK ADSENQARKYMNAVRKRKGLYVEEKIVEHAEKQRTLSKNK
- Number of residues
- 1120
- Molecular Weight
- 125428.745
- Theoretical pI
- 5.72
- GO Classification
- FunctionsGTP binding / GTPase activity / ribosome bindingProcessesmature ribosome assembly / translationComponentsintracellular
- General Function
- Ribosome binding
- Specific Function
- Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0012822|Elongation factor Tu GTP-binding domain-containing protein 1 (EFTUD1) ATGGTGCTCAACAGTTTGGATAAGATGATTCAACTCCAGAAAAACACTGCCAACATCAGG AATATTTGTGTTTTGGCTCATGTTGACCATGGTAATGAGGAGTACCTGATCAATCTGATA GACTCTCCAGGACACGTGGACTTTTCCTCAGAAGTATCAACCGCTGTTCGCATTTGTGAT GGATGCATCATTGTGGTAGATGCTGTGGAAGGAGTCTGTCCACAGACACAGGCAGTTCTG CGACAAGCTTGGCTTGAAAACATCCGTCCGGTTTTAGTGATTAATAAGATTGATCGCTTG ATAGTGGAACTGAAATTCACCCCACAAGAGGCCTATTCTCACCTCAAGAATATTTTAGAA CAGATTAATGCGCTCACAGGGACTCTTTTTACTTCTAAAGTCCTAGAAGAAAGAGCAGAG AGGGAGACTGAATCCCAAGTGAATCCAAATTCTGAACAAGGAGAGCAAGTATATGACTGG AGCACTGGCTTGGAGGACACAGATGATTCTCACCTTTACTTCTCTCCAGAACAGGGAAAT GTGGTGTTTACCAGTGCAATAGATGGGTGGGGCTTTGGAATTGAGCACTTCGCCAGAATC TACAGTCAAAAAATTGGCATCAAAAAGGAAGTTCTTATGAAAACCTTGTGGGGAGATTAC TATATAAATATGAAGGCTAAAAAGATCATGAAGGGTGATCAGGCCAAAGGAAAGAAACCT TTATTTGTACAGTTGATCCTGGAAAATATATGGAGTTTGTATGATGCTGTTTTGAAAAAG GACAAAGACAAAATTGATAAAATAGTGACTTCTTTAGGATTAAAAATTGGAGCCCGGGAG GCACGACATTCAGACCCTAAAGTTCAGATCAACGCCATTTGCAGTCAGTGGCTACCCATA TCCCATGCTGTTCTTGCTATGGTGTGTCAGAAACTTCCTAGTCCCCTTGATATTACAGCT GAGAGAGTGGAGAGACTGATGTGCACAGGATCACAAACTTTTGACTCTTTTCCACCAGAA ACTCAAGCACTGAAAGCAGCTTTTATGAAATGTGGAAGTGAGGACACTGCTCCAGTTATT ATATTTGTTTCCAAAATGTTTGCAGTTGATGCTAAGGCCTTGCCTCAGAATAAGCCAAGG CCTCTCACTCAAGAAGAAATTGCTCAGAGACGTGAGCGTGCAAGACAAAGGCATGCAGAG AAGCTTGCAGCAGCACAGGGACAGGCACCCTTGGAGCCCACCCAAGATGGGAGTGCCATT GAAACATGTCCAAAAGGAGAGGAGCCAAGAGGTGACGAGCAACAGGTGGAAAGTATGACC CCTAAACCTGTGCTCCAGGAAGAAAACAACCAAGAGTCTTTTATTGCATTTGCTCGGGTG TTCAGTGGTGTGGCTCGAAGAGGAAAGAAAATTTTTGTCTTGGGGCCCAAATACAGTCCT CTTGAGTTTTTACGAAGGGTACCATTAGGCTTCTCAGCTCCACCAGATGGCCTCCCCCAA GTCCCCCACATGGCATACTGTGCTCTGGAAAACCTGTATCTTCTGATGGGAAGGGAACTG GAATATCTAGAGGAGGTACCTCCAGGAAATGTGCTAGGAATAGGAGGCCTTCAAGATTTT GTGCTGAAATCTGCAACACTGTGTAGCCTGCCATCCTGCCCACCATTTATACCACTCAAC TTCGAAGCCACTCCTATTGTGAGAGTTGCTGTTGAACCAAAACATCCAAGTGAAATGCCT CAGCTCGTAAAAGGAATGAAACTGTTAAACCAGGCTGATCCCTGTGTCCAGATTTTAATT CAGGAAACGGGAGAGCACGTTTTAGTCACAGCAGGAGAAGTCCACCTTCAGCGATGCCTG GATGACTTAAAAGAAAGGTTTGCAAAGATTCATATCAGTGTATCTGAACCTATTATTCCA TTCAGAGAAACAATCACAAAACCCCCAAAAGTTGACATGGTCAATGAAGAAATAGGCAAA CAGCAAAAAGTTGCAGTCATACACCAAATGAAAGAAGATCAAAGCAAAATCCCTGAAGGA ATCCAAGTTGACTCTGACGGGCTAATCACCATAACAACTCCCAATAAACTTGCCACGCTC AGTGTTCGAGCCATGCCCCTTCCAGAAGAAGTCACCCAGATTCTGGAAGAAAATAGTGAT TTGATTCGTTCTATGGAGCAGTTGACATCCTCTTTGAATGAGGGTGAAAATACTCACATG ATTCATCAGAAGACCCAAGAGAAAATTTGGGAATTCAAAGGAAAACTGGAGCAACACCTA ACAGGGAGAAGATGGAGGAACATTGTTGACCAAATCTGGTCATTTGGCCCAAGAAAATGT GGGCCCAACATACTAGTCAATAAAAGTGAAGATTTTCAGAACTCAGTATGGACAGGTCCA GCTGACAAAGCTTCAAAAGAAGCCAGTAGATACCGAGATTTGGGCAATAGCATTGTGAGT GGCTTCCAACTAGCAACCCTCTCTGGCCCCATGTGTGAGGAGCCTCTCATGGGTGTCTGT TTTGTTCTGGAAAAATGGGACCTAAGTAAATTTGAGGAACAAGGAGCAAGTGATCTGGCA AAAGAGGGACAGGAGGAAAATGAAACCTGTTCTGGTGGAAATGAAAACCAAGAGCTACAA GATGGCTGCTCTGAGGCCTTTGAGAAGAGGACATCACAGAAAGGAGAATCTCCACTCACT GACTGCTATGGACCTTTCTCAGGACAGCTAATTGCCACCATGAAAGAAGCATGTCGCTAT GCACTGCAAGTGAAACCTCAGCGCCTGATGGCAGCTATGTACACATGTGACATCATGGCC ACTGGTGATGTTCTCGGTCGAGTCTATGCTGTCTTGTCAAAGAGAGAAGGTCGGGTACTT CAAGAAGAAATGAAAGAAGGGACAGACATGTTCATCATCAAGGCTGTGCTGCCTGTTGCT GAAAGCTTTGGTTTTGCTGATGAAATCAGGAAGAGGACAAGTGGCCTGGCCAGCCCACAA CTAGTATTCAGCCATTGGGAGATCATTCCCAGTGACCCCTTCTGGGTGCCAACTACTGAG GAGGAATACTTGCACTTTGGGGAGAAGGCTGACTCTGAGAACCAAGCCCGGAAGTACATG AACGCAGTACGAAAGCGGAAGGGGCTTTATGTGGAAGAAAAGATTGTGGAGCATGCAGAA AAGCAGAGGACACTCAGCAAAAATAAGTAG
- Chromosome Location
- 15
- Locus
- 15q25.2
- External Identifiers
Resource Link UniProtKB ID Q7Z2Z2 UniProtKB Entry Name ETUD1_HUMAN GenBank Protein ID 10434992 GenBank Gene ID AK023181 HGNC ID HGNC:25789 - General References
- Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
- Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [Article]
- Zody MC, Garber M, Sharpe T, Young SK, Rowen L, O'Neill K, Whittaker CA, Kamal M, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Kodira CD, Madan A, Qin S, Yang X, Abbasi N, Abouelleil A, Arachchi HM, Baradarani L, Birditt B, Bloom S, Bloom T, Borowsky ML, Burke J, Butler J, Cook A, DeArellano K, DeCaprio D, Dorris L 3rd, Dors M, Eichler EE, Engels R, Fahey J, Fleetwood P, Friedman C, Gearin G, Hall JL, Hensley G, Johnson E, Jones C, Kamat A, Kaur A, Locke DP, Madan A, Munson G, Jaffe DB, Lui A, Macdonald P, Mauceli E, Naylor JW, Nesbitt R, Nicol R, O'Leary SB, Ratcliffe A, Rounsley S, She X, Sneddon KM, Stewart S, Sougnez C, Stone SM, Topham K, Vincent D, Wang S, Zimmer AR, Birren BW, Hood L, Lander ES, Nusbaum C: Analysis of the DNA sequence and duplication history of human chromosome 15. Nature. 2006 Mar 30;440(7084):671-5. [Article]
- Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M: Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009 Aug 14;325(5942):834-40. doi: 10.1126/science.1175371. Epub 2009 Jul 16. [Article]
- Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]
- Finch AJ, Hilcenko C, Basse N, Drynan LF, Goyenechea B, Menne TF, Gonzalez Fernandez A, Simpson P, D'Santos CS, Arends MJ, Donadieu J, Bellanne-Chantelot C, Costanzo M, Boone C, McKenzie AN, Freund SM, Warren AJ: Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome. Genes Dev. 2011 May 1;25(9):917-29. doi: 10.1101/gad.623011. [Article]
- Van Damme P, Lasa M, Polevoda B, Gazquez C, Elosegui-Artola A, Kim DS, De Juan-Pardo E, Demeyer K, Hole K, Larrea E, Timmerman E, Prieto J, Arnesen T, Sherman F, Gevaert K, Aldabe R: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12449-54. doi: 10.1073/pnas.1210303109. Epub 2012 Jul 18. [Article]